|
#
|
Concept name
|
Type
|
Relation
|
Support
|
Score
|
|
1
|
Regulator of G protein signalling
|
Domain
|
Known
|
Explain
|
7.58377
|
|
2
|
RGS8 gene
|
Gene
|
Known
|
Explain
|
3.32738
|
|
3
|
RGS21 gene
|
Gene
|
Known
|
Explain
|
3.32738
|
|
4
|
Regulator of G protein signalling-like fold
|
Domain
|
Known
|
Explain
|
3.19887
|
|
5
|
RGS22 gene
|
Gene
|
Known
|
Explain
|
3.13350
|
|
6
|
RGS17 gene
|
Gene
|
Known
|
Explain
|
2.96347
|
|
7
|
SNX25 gene
|
Gene
|
Known
|
Explain
|
2.49468
|
|
8
|
SNX14 gene
|
Gene
|
Known
|
Explain
|
2.43810
|
|
9
|
RGS18 gene
|
Gene
|
Known
|
Explain
|
2.29186
|
|
10
|
RGS11 gene
|
Gene
|
Known
|
Explain
|
1.95180
|
|
11
|
SNX13 gene
|
Gene
|
Known
|
Explain
|
1.94253
|
|
12
|
RGS14 gene
|
Gene
|
Known
|
Explain
|
1.87343
|
|
13
|
RGS13 gene
|
Gene
|
Known
|
Explain
|
1.82820
|
|
14
|
RGS6 gene
|
Gene
|
Known
|
Explain
|
1.78098
|
|
15
|
RGS5 gene
|
Gene
|
Known
|
Explain
|
1.75258
|
|
16
|
GRK4 gene
|
Gene
|
Known
|
Explain
|
1.54084
|
|
17
|
RGS10 gene
|
Gene
|
Known
|
Explain
|
1.42398
|
|
18
|
GRK7 gene
|
Gene
|
Known
|
Explain
|
1.37705
|
|
19
|
RGS7 gene
|
Gene
|
Known
|
Explain
|
1.36498
|
|
20
|
RGS9 gene
|
Gene
|
Known
|
Explain
|
1.27047
|
|
21
|
RGS16 gene
|
Gene
|
Known
|
Explain
|
1.24008
|
|
22
|
RGS1 gene
|
Gene
|
Known
|
Explain
|
1.22606
|
|
23
|
RGS4 gene
|
Gene
|
Known
|
Explain
|
1.21136
|
|
24
|
RGS19 gene
|
Gene
|
Known
|
Explain
|
1.20104
|
|
25
|
RGS12 gene
|
Gene
|
Known
|
Explain
|
1.16866
|
|
26
|
RGS20 gene
|
Gene
|
Known
|
Explain
|
1.11364
|
|
27
|
RGS3 gene
|
Gene
|
Known
|
Explain
|
1.03904
|
|
28
|
GRK6 gene
|
Gene
|
Known
|
Explain
|
1.03824
|
|
29
|
negative regulation of signal transduction
|
Function
|
Inferred
|
Explain
|
0.81451
|
|
30
|
GRK5 gene
|
Gene
|
Known
|
Explain
|
0.75699
|
|
31
|
RGS2 gene
|
Gene
|
Known
|
Explain
|
0.64633
|
|
32
|
signal transducer activity
|
Function
|
Inferred
|
Explain
|
0.42973
|
|
33
|
GTPase activator activity
|
Function
|
Inferred
|
Explain
|
0.39476
|
|
34
|
regulation of G-protein coupled receptor protein signaling pathway
|
Function
|
Inferred
|
Explain
|
0.28853
|
|
35
|
Sorting nexin, C-terminal
|
Domain
|
Inferred
|
Explain
|
0.28361
|
|
36
|
Phox-associated domain
|
Domain
|
Inferred
|
Explain
|
0.27256
|
|
37
|
MYH9 gene
|
Gene
|
Known
|
Explain
|
0.26021
|
|
38
|
G-protein, gamma-like subunit
|
Domain
|
Inferred
|
Explain
|
0.14620
|
|
39
|
GNAI3 gene
|
Gene
|
Inferred
|
Explain
|
0.13777
|
|
40
|
GNAI1 gene
|
Gene
|
Inferred
|
Explain
|
0.11578
|
|
41
|
GNAO1 gene
|
Gene
|
Inferred
|
Explain
|
0.09632
|
|
42
|
OSTM1 gene
|
Gene
|
Inferred
|
Explain
|
0.08320
|
|
43
|
heterotrimeric G-protein complex location
|
Component
|
Inferred
|
Explain
|
0.08173
|
|
44
|
Pleckstrin/G-protein, interacting region
|
Domain
|
Inferred
|
Explain
|
0.07591
|
|
45
|
Phox-like
|
Domain
|
Inferred
|
Explain
|
0.06662
|
|
46
|
GNB5 gene
|
Gene
|
Inferred
|
Explain
|
0.06258
|
|
47
|
GPCR kinase
|
Domain
|
Inferred
|
Explain
|
0.06098
|
|
48
|
GNAI2 gene
|
Gene
|
Inferred
|
Explain
|
0.06009
|
|
49
|
G-protein coupled receptor kinase activity
|
Function
|
Inferred
|
Explain
|
0.05945
|
|
50
|
GNAQ gene
|
Gene
|
Inferred
|
Explain
|
0.05833
|
|
51
|
phosphoinositide binding
|
Function
|
Inferred
|
Explain
|
0.05289
|
|
52
|
Rho GTP exchange factor
|
Domain
|
Inferred
|
Explain
|
0.05011
|
|
53
|
PX-associated, sorting nexin 13
|
Domain
|
Inferred
|
Explain
|
0.04695
|
|
54
|
Cell membrane
|
Component
|
Inferred
|
Explain
|
0.03833
|
|
55
|
Cytoplasm
|
Component
|
Inferred
|
Explain
|
0.03272
|
|
56
|
GoLoco motif
|
Domain
|
Inferred
|
Explain
|
0.03214
|
|
57
|
SNX19 gene
|
Gene
|
Inferred
|
Explain
|
0.03126
|
|
58
|
GNAZ gene
|
Gene
|
Inferred
|
Explain
|
0.03034
|
|
59
|
Raf-like Ras-binding
|
Domain
|
Inferred
|
Explain
|
0.02900
|
|
60
|
positive regulation of GTPase activity
|
Function
|
Inferred
|
Explain
|
0.02752
|
|
61
|
AGC-kinase, C-terminal
|
Domain
|
Inferred
|
Explain
|
0.02665
|
|
62
|
Cell Communication
|
Function
|
Inferred
|
Explain
|
0.02660
|
|
63
|
GDE1 gene
|
Gene
|
Inferred
|
Explain
|
0.02321
|
|
64
|
Blocadren
|
Compound
|
Inferred
|
Explain
|
0.01652
|
|
65
|
RGS9BP gene
|
Gene
|
Inferred
|
Explain
|
0.01638
|
|
66
|
KEGG:hsa04744
|
|
Inferred
|
Explain
|
0.01146
|
|
67
|
PERRS Gene
|
Disease
|
Inferred
|
Explain
|
0.01129
|
|
68
|
receptor signaling protein activity
|
Function
|
Inferred
|
Explain
|
0.01063
|
|
69
|
STMN2 gene
|
Gene
|
Inferred
|
Explain
|
0.01042
|
|
70
|
Phosphorhodopsin
|
Compound
|
Inferred
|
Explain
|
0.01010
|
|
71
|
Rho guanine nucleotide exchange factor activity
|
Function
|
Inferred
|
Explain
|
0.00943
|
|
72
|
Chemokine signaling pathway - Homo sapiens (human)
|
Pathway
|
Inferred
|
Explain
|
0.00857
|
|
73
|
negative regulation of G-protein coupled receptor protein signaling pathway
|
Function
|
Inferred
|
Explain
|
0.00787
|
|
74
|
GNAT1 gene
|
Gene
|
Inferred
|
Explain
|
0.00770
|
|
75
|
Winged helix repressor DNA-binding
|
Domain
|
Inferred
|
Explain
|
0.00724
|
|
76
|
Psychoses, Drug
|
Disease
|
Inferred
|
Explain
|
0.00715
|
|
77
|
nickel sulfate
|
Compound
|
Inferred
|
Explain
|
0.00697
|
|
78
|
CALM1 gene
|
Gene
|
Inferred
|
Explain
|
0.00665
|
|
79
|
protein transport
|
Function
|
Inferred
|
Explain
|
0.00664
|
|
80
|
BDKRB2 gene
|
Gene
|
Inferred
|
Explain
|
0.00650
|
|
81
|
Serine/threonine protein kinase
|
Domain
|
Inferred
|
Explain
|
0.00638
|
|
82
|
Benzo(a)pyrene
|
Compound
|
Inferred
|
Explain
|
0.00615
|
|
83
|
RCVRN gene
|
Gene
|
Inferred
|
Explain
|
0.00614
|
|
84
|
calmodulin binding
|
Function
|
Inferred
|
Explain
|
0.00601
|
|
85
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
|
Compound
|
Inferred
|
Explain
|
0.00597
|
|
86
|
Endocytosis - Homo sapiens (human)
|
Pathway
|
Inferred
|
Explain
|
0.00594
|
|
87
|
FSHR gene
|
Gene
|
Inferred
|
Explain
|
0.00554
|
|
88
|
Serine/threonine protein kinase-related
|
Domain
|
Inferred
|
Explain
|
0.00547
|
|
89
|
Rhodopsin
|
Compound
|
Inferred
|
Explain
|
0.00537
|
|
90
|
Essential Hypertension
|
Disease
|
Inferred
|
Explain
|
0.00534
|
|
91
|
Tamoxifen
|
Compound
|
Inferred
|
Explain
|
0.00509
|
|
92
|
inactivation of MAPK activity
|
Function
|
Inferred
|
Explain
|
0.00503
|
|
93
|
Protein kinase, ATP binding site
|
Domain
|
Inferred
|
Explain
|
0.00488
|
|
94
|
7-ethyl-10-hydroxycamptothecin
|
Compound
|
Inferred
|
Explain
|
0.00480
|
|
95
|
Serine/threonine protein kinase, active site
|
Domain
|
Inferred
|
Explain
|
0.00480
|
|
96
|
SNCB gene
|
Gene
|
Inferred
|
Explain
|
0.00477
|
|
97
|
GRK1 gene
|
Gene
|
Inferred
|
Explain
|
0.00469
|
|
98
|
DMAP1 gene
|
Gene
|
Inferred
|
Explain
|
0.00463
|
|
99
|
Protein kinase, core
|
Domain
|
Inferred
|
Explain
|
0.00455
|
|
100
|
Protein Binding
|
Function
|
Inferred
|
Explain
|
0.00452
|