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I-kappaB kinase/NF-kappaB cascade Function  •  C1155580

Definition: A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase. [GOC:jl, PMID:12773372][...]

Synonyms: I-kappaB kinase/NF-kappaB cascade • NIK-I-kappaB/NF-kappaB cascade

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# Entity Type Relation Support Relative specificity
1 IRAK1BP1 gene Gene Known Explain
2 NKIRAS2 gene Gene Known Explain
3 NLRC3 gene Gene Known Explain
4 AZI2 gene Gene Known Explain
5 TIAF1 gene Gene Known Explain
6 NKIRAS1 gene Gene Known Explain
7 TIFA gene Gene Known Explain
8 TNIP2 gene Gene Known Explain
9 ZNF675 gene Gene Known Explain
10 TAB3 gene Gene Known Explain
11 TICAM2 gene Gene Known Explain
12 LY96 gene Gene Known Explain
13 TLR8 gene Gene Known Explain
14 PTPLAD1 gene Gene Known Explain
15 TICAM1 gene Gene Known Explain
16 TAB1 gene Gene Known Explain
17 AVPR2 gene Gene Known Explain
18 TAB2 gene Gene Known Explain
19 IRAK2 gene Gene Known Explain
20 UBA52 gene Gene Known Explain
21 RPS27A gene Gene Known Explain
22 TBK1 gene Gene Known Explain
23 RIPK3 gene Gene Known Explain
24 protein kinase cascade Function Known Explain
25 BCL3 gene Gene Known Explain
26 MAP3K7 gene Gene Known Explain
27 BTK gene Gene Known Explain
28 MAP3K14 gene Gene Known Explain
29 UBB gene Gene Known Explain
30 TLR4 gene Gene Known Explain
31 STAT1 gene Gene Known Explain
32 IKBKG gene Gene Known Explain
33 TRAF6 gene Gene Known Explain
34 UBC gene Gene Known Explain
35 IRAK1 gene Gene Inferred Explain
36 MyD88-independent toll-like receptor signaling pathway Function Inferred Explain
37 toll-like receptor 4 signaling pathway Function Inferred Explain
38 Toll signaling pathway Function Inferred Explain
39 toll-like receptor 2 signaling pathway Function Inferred Explain
40 toll-like receptor 1 signaling pathway Function Inferred Explain
41 MyD88-dependent toll-like receptor signaling pathway Function Inferred Explain
42 toll-like receptor signaling pathway Function Inferred Explain
43 NACHT nucleoside triphosphatase Domain Inferred Explain
44 toll-like receptor 3 signaling pathway Function Inferred Explain
45 NFKBIB gene Gene Inferred Explain
46 negative regulation of NF-kappaB transcription factor activity Function Inferred Explain
47 positive regulation of NF-kappaB transcription factor activity Function Inferred Explain
48 stress-activated MAPK cascade Function Inferred Explain
49 Toll-like receptor signaling pathway - Homo sapiens (human) Pathway Inferred Explain
50 TIFAB gene Gene Inferred Explain
51 JNK cascade Function Inferred Explain
52 Innate Immune Response Disease Inferred Explain
53 IPR022008 Domain Inferred Explain
54 Wall of endosome Component Inferred Explain
55 lipopolysaccharide-mediated signaling pathway Function Inferred Explain
56 T-Cell Activation Function Inferred Explain
57 NFKBIA gene Gene Inferred Explain
58 Cytoplasm Component Inferred Explain
59 GTP catabolic process Function Inferred Explain
60 positive regulation of interferon-beta biosynthetic process Function Inferred Explain
61 activation of MAPK activity Function Inferred Explain
62 TRAF2 gene Gene Inferred Explain
63 KEGG:hsa04622 Pathway Inferred Explain
64 RELA gene Gene Inferred Explain
65 Protein Binding Function Inferred Explain
66 positive regulation of I-kappaB kinase/NF-kappaB cascade Function Inferred Explain
67 ELF3 gene Gene Inferred Explain
68 NFKB2 gene Gene Inferred Explain
69 small GTPase mediated signal transduction Function Inferred Explain
70 GTPase activity Function Inferred Explain
71 Ubiquitin system component Cue Domain Inferred Explain
72 Forkhead-associated Domain Inferred Explain
73 MYD88 gene Gene Inferred Explain
74 TUBA3C gene Gene Inferred Explain
75 OTUD7B gene Gene Inferred Explain
76 SDCBP2 gene Gene Inferred Explain
77 nucleotide binding Function Inferred Explain
78 JAK3 gene Gene Inferred Explain
79 TIRAP gene Gene Inferred Explain
80 TLR3 gene Gene Inferred Explain
81 KEGG:hsa04621 Pathway Inferred Explain
82 C21orf7 gene Gene Inferred Explain
83 IRF7 gene Gene Inferred Explain
84 negative regulation of osteoclast differentiation Function Inferred Explain
85 MAP3K8 gene Gene Inferred Explain
86 IRF3 gene Gene Inferred Explain
87 Cytoplasmic matrix Component Inferred Explain
88 ZCCHC11 gene Gene Inferred Explain
89 IKBKE gene Gene Inferred Explain
90 ODC1 gene Gene Inferred Explain
91 REL gene Gene Inferred Explain
92 NFKB1 gene Gene Inferred Explain
93 TNFAIP3 gene Gene Inferred Explain
94 anti-apoptosis Function Inferred Explain
95 RIPK1 gene Gene Inferred Explain
96 TRIB3 gene Gene Inferred Explain
97 Cell Nucleus Component Inferred Explain
98 negative regulation of JNK cascade Function Inferred Explain
99 NUDT18 gene Gene Inferred Explain
100 regulation of ossification Function Inferred Explain

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