MSH6 gene

Gene • C0879393

Definition

This gene is involved in mismatch repair and plays a role in several cancers.

Synonyms

MSH6 gene • G/T MISMATCH-BINDING PROTEIN • MSH6 • MutS, E. COLI, HOMOLOG OF, 6 • mutS homolog 6 (E. coli) • GTBP • MutS Homolog 6 (E. coli) Gene

Linked items?Related concepts, ordered by their global importance in the network.

Protein Binding    Cell Nucleus    ATP binding    nucleotide binding    tert-Butylhydroperoxide    Doxorubicin    MYC gene    GSK3B gene    MAPK14 gene    CDK2 gene    UBC gene    EP300 gene    Pathways in cancer - Homo sapiens (human)    CREBBP gene    DNA Repair    BRCA1 gene    magnesium ion binding    MCC gene    ATM gene    PCNA gene   

Related concepts

# Concept name Type Relation Support Score
1 DNA mismatch repair protein MutS-homolog MSH6 Domain Known Explain 2.67934
2 single thymine insertion binding Function Known Explain 2.21780
3 single base insertion or deletion binding Function Known Explain 1.98714
4 DNA mismatch repair protein Msh6 Domain Known Explain 1.76985
5 single guanine insertion binding Function Known Explain 1.75689
6 Endometrial Carcinoma Disease Known Explain 1.54122
7 oxidized purine DNA binding Function Known Explain 1.43756
8 guanine/thymine mispair binding Function Known Explain 1.31882
9 DNA mismatch repair protein MutS, N-terminal Domain Known Explain 1.26303
10 DNA mismatch repair protein MutS, C-terminal Domain Known Explain 1.23742
11 MutSalpha complex Component Known Explain 1.07754
12 DNA mismatch repair protein MutS-like, N-terminal Domain Known Explain 1.01675
13 four-way junction DNA binding Function Known Explain 1.01059
14 Turcot syndrome Disease Known Explain 0.98385
15 DNA mismatch repair protein MutS, connector Domain Known Explain 0.98144
16 DNA mismatch repair protein MutS, clamp Domain Known Explain 0.94848
17 DNA mismatch repair protein MutS, core Domain Known Explain 0.91384
18 MutLalpha complex binding Function Known Explain 0.85614
19 mismatched DNA binding Function Known Explain 0.80936
20 MSH2 gene Gene Known Explain 0.78442
21 positive regulation of helicase activity Function Known Explain 0.76703
22 meiotic mismatch repair Function Known Explain 0.72192
23 maintenance of DNA repeat elements Function Known Explain 0.65587
24 somatic recombination of immunoglobulin gene segments Function Known Explain 0.62445
25 Mismatch Repair Function Known Explain 0.56921
26 somatic hypermutation of immunoglobulin genes Function Known Explain 0.55615
27 Hereditary Nonpolyposis Colorectal Neoplasms Disease Known Explain 0.55551
28 PWWP Domain Known Explain 0.52088
29 negative regulation of DNA recombination Function Known Explain 0.47679
30 determination of adult life span Function Known Explain 0.47110
31 Immunoglobulin Class Switching Function Known Explain 0.45451
32 MSH3 gene Gene Inferred Explain 0.41470
33 DNA mismatch repair protein, MSH2 Domain Inferred Explain 0.29379
34 Mismatch repair - Homo sapiens (human) Pathway Known Explain 0.25191
35 induction of apoptosis by intracellular signals Function Known Explain 0.25098
36 PMS2 gene Gene Known Explain 0.24176
37 ADP binding Function Known Explain 0.23886
38 DNA mismatch repair protein MutS, type 1 Domain Inferred Explain 0.23727
39 DNA damage response, signal transduction resulting in induction of apoptosis Function Known Explain 0.23265
40 Meiotic Recombination Function Known Explain 0.20342
41 Nuclear chromatin Component Known Explain 0.18042
42 CLSPN gene Gene Known Explain 0.17395
43 Nuclear chromosome Component Known Explain 0.17393
44 MLH1 gene Gene Known Explain 0.17134
45 MUTYH gene Gene Known Explain 0.16868
46 Endometrial Neoplasms Disease Known Explain 0.15418
47 Methylnitrosourea Compound Known Explain 0.14109
48 DNA dependent adenosinetriphosphatase activity Function Known Explain 0.13216
49 response to UV Function Known Explain 0.12547
50 oxidized DNA binding Function Inferred Explain 0.11329
51 TOPBP1 Gene Gene Known Explain 0.11071
52 RFC1 gene Gene Known Explain 0.10627
53 MRE11A gene Gene Known Explain 0.10625
54 DNA insertion or deletion binding Function Inferred Explain 0.10386
55 RAD50 gene Gene Known Explain 0.10008
56 damaged DNA binding Function Known Explain 0.09783
57 Epithelial ovarian cancer Disease Known Explain 0.09747
58 NBN gene Gene Known Explain 0.09320
59 MSH4 gene Gene Inferred Explain 0.09099
60 Colorectal cancer - Homo sapiens (human) Pathway Known Explain 0.08006
61 SMC1A gene Gene Known Explain 0.07777
62 MSH5 gene Gene Inferred Explain 0.07494
63 ATR gene Gene Known Explain 0.07300
64 BLM gene Gene Known Explain 0.07215
65 AIRE gene Gene Known Explain 0.06922
66 lycopene Compound Known Explain 0.06900
67 MED9 gene Gene Known Explain 0.06769
68 gedunin Compound Known Explain 0.06501
69 PSMD4 gene Gene Known Explain 0.06379
70 tripterine Compound Known Explain 0.05964
71 MLH3 gene Gene Inferred Explain 0.05958
72 CHEK1 gene Gene Known Explain 0.05949
73 CASP4 gene Gene Known Explain 0.05918
74 CSNK1D gene Gene Known Explain 0.05839
75 BARD1 gene Gene Known Explain 0.05654
76 PCNA gene Gene Known Explain 0.05090
77 PMS2CL gene Gene Inferred Explain 0.04872
78 double-stranded DNA binding Function Known Explain 0.04661
79 somatic recombination of immunoglobulin genes during immune response Function Inferred Explain 0.04573
80 adenosinetriphosphatase activity Function Known Explain 0.04116
81 DNA mismatch repair protein MutS, type 2 Domain Inferred Explain 0.03948
82 trans-10,cis-12-conjugated linoleic acid Compound Known Explain 0.03860
83 DNA Repair Function Known Explain 0.03701
84 ATM gene Gene Known Explain 0.03633
85 DNA secondary structure binding Function Inferred Explain 0.03416
86 mismatch repair complex binding Function Inferred Explain 0.03275
87 PRKCZ gene Gene Known Explain 0.03269
88 chromatin binding Function Known Explain 0.03217
89 mismatch repair complex Component Inferred Explain 0.03113
90 BRCA1 gene Gene Known Explain 0.02980
91 CSNK2A2 gene Gene Known Explain 0.02770
92 regulation of helicase activity Function Inferred Explain 0.02375
93 MCC gene Gene Known Explain 0.02333
94 magnesium ion binding Function Known Explain 0.02314
95 miRBase:hsa-mir-200c MicroRNA Inferred Explain 0.02282
96 somatic diversification of immunoglobulins Function Inferred Explain 0.02272
97 somatic hypermutation of immunoglobulin genes during immune response Function Inferred Explain 0.02234
98 Holliday junction resolvase, poxvirus Domain Inferred Explain 0.02125
99 maintenance of rDNA Function Inferred Explain 0.02029
100 loop DNA binding Function Inferred Explain 0.01858