Tamoxifen

Compound • C0039286

Definition

An antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result

Synonyms

Tamoxifen • Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)- • TAM • TMX • 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene • (Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine • Tamoxifen [Chemical/Ingredient]

Linked items?Related concepts, ordered by their global importance in the network.

ESR1 gene    TP53 gene    MAPK1 gene    MYC gene    TNF gene    EGFR gene    BCL2 gene    ESR2 gene    CYP3A4 gene    RELA gene    CASP3 gene    MAPK3 gene    AKT1 gene    MAPK14 gene    AR gene    JUN gene    CYP1A1 gene    SRC gene    CYP1A2 gene    CDK2 gene   

Related concepts

# Concept name Type Relation Support Score
1 Raloxifene Compound Known Explain 0.01368
2 Toremifene Compound Known Explain 0.01283
3 BCAR4 gene Gene Known Explain 0.01194
4 GYPE gene Gene Known Explain 0.01126
5 CECR6 gene Gene Known Explain 0.01117
6 SYNGR4 gene Gene Known Explain 0.01073
7 Spermatocele Disease Known Explain 0.01028
8 MAGEA8 gene Gene Known Explain 0.00964
9 Fibromatosis, Abdominal Disease Known Explain 0.00920
10 OSBPL7 gene Gene Known Explain 0.00849
11 C2CD2 gene Gene Known Explain 0.00822
12 SPATA13 gene Gene Known Explain 0.00810
13 Melanoma, Amelanotic Disease Known Explain 0.00800
14 PF4V1 gene Gene Known Explain 0.00785
15 Fibromatosis, Aggressive Disease Known Explain 0.00777
16 POU6F1 gene Gene Known Explain 0.00763
17 ZBTB22 gene Gene Known Explain 0.00750
18 Manganese Poisoning Other Known Explain 0.00749
19 CCDC86 gene Gene Known Explain 0.00745
20 DKK4 gene Gene Known Explain 0.00743
21 Abdominal Neoplasms Disease Known Explain 0.00734
22 CYLC2 gene Gene Known Explain 0.00733
23 MRPL33 gene Gene Known Explain 0.00732
24 RFTN1 gene Gene Known Explain 0.00729
25 L3MBTL gene Gene Known Explain 0.00728
26 Estradiol Compound Inferred Explain 0.00728
27 STARD8 gene Gene Known Explain 0.00701
28 ANGPTL2 gene Gene Known Explain 0.00651
29 TMEM158 gene Gene Known Explain 0.00648
30 ARTN gene Gene Known Explain 0.00639
31 TTC35 gene Gene Known Explain 0.00637
32 SOSTDC1 gene Gene Known Explain 0.00634
33 TFF2 gene Gene Known Explain 0.00634
34 RRP9 gene Gene Known Explain 0.00631
35 H19 gene Gene Known Explain 0.00628
36 PPP1R12B gene Gene Known Explain 0.00621
37 ABLIM3 gene Gene Known Explain 0.00616
38 KLRC3 gene Gene Known Explain 0.00593
39 CD6 gene Gene Known Explain 0.00589
40 SEMA4B gene Gene Known Explain 0.00586
41 LGR5 gene Gene Known Explain 0.00583
42 KLRC4 gene Gene Known Explain 0.00581
43 CTRL gene Gene Known Explain 0.00578
44 NKD1 gene Gene Known Explain 0.00576
45 APBA3 gene Gene Known Explain 0.00571
46 MLANA gene Gene Known Explain 0.00570
47 HEG1 gene Gene Known Explain 0.00567
48 FNDC4 gene Gene Known Explain 0.00565
49 TP53I11 gene Gene Known Explain 0.00561
50 KLRC1 gene Gene Known Explain 0.00559
51 KRT86 gene Gene Known Explain 0.00555
52 FLRT1 gene Gene Known Explain 0.00551
53 RAB40C gene Gene Known Explain 0.00546
54 MARCKSL1 gene Gene Known Explain 0.00545
55 ALCAM gene Gene Known Explain 0.00545
56 RASEF gene Gene Known Explain 0.00543
57 MAN2B2 gene Gene Known Explain 0.00539
58 NOVA1 gene Gene Known Explain 0.00531
59 Lipoidosis Disease Known Explain 0.00528
60 MR1 gene Gene Known Explain 0.00521
61 RGS13 gene Gene Known Explain 0.00517
62 LRRFIP1 gene Gene Known Explain 0.00507
63 SLC4A8 gene Gene Known Explain 0.00505
64 SFRS2IP gene Gene Known Explain 0.00504
65 TNR gene Gene Known Explain 0.00504
66 GDPD3 gene Gene Known Explain 0.00502
67 Stilbenes Compound Known Explain 0.00497
68 H2AFZ gene Gene Known Explain 0.00497
69 Female Urogenital Diseases Disease Known Explain 0.00491
70 FAP gene Gene Known Explain 0.00486
71 LRIG1 gene Gene Known Explain 0.00486
72 Carcinoma, Transitional Cell Disease Known Explain 0.00485
73 Spinal Cord Injuries Other Known Explain 0.00482
74 NEK7 gene Gene Known Explain 0.00480
75 GNB4 gene Gene Known Explain 0.00477
76 SPATA2 gene Gene Known Explain 0.00476
77 HCRTR2 gene Gene Known Explain 0.00476
78 Protein Binding Function Inferred Explain 0.00469
79 GPER gene Gene Known Explain 0.00469
80 ARHGAP29 gene Gene Known Explain 0.00466
81 FICD gene Gene Known Explain 0.00465
82 EDIL3 gene Gene Known Explain 0.00463
83 HPN gene Gene Known Explain 0.00460
84 NAB1 gene Gene Known Explain 0.00457
85 PLA2G7 gene Gene Known Explain 0.00457
86 MC2R gene Gene Known Explain 0.00456
87 HOMER2 gene Gene Known Explain 0.00455
88 FKBPL gene Gene Known Explain 0.00453
89 ABCC11 gene Gene Known Explain 0.00453
90 LASS6 gene Gene Known Explain 0.00451
91 ADAM22 gene Gene Known Explain 0.00450
92 HAPLN1 gene Gene Known Explain 0.00450
93 MST1 gene Gene Known Explain 0.00450
94 DHX38 gene Gene Known Explain 0.00448
95 NUPR1 gene Gene Known Explain 0.00445
96 CXCR7 gene Gene Known Explain 0.00445
97 AIPL1 gene Gene Known Explain 0.00441
98 CRYM gene Gene Known Explain 0.00441
99 IFIT2 gene Gene Known Explain 0.00440
100 TMOD1 gene Gene Known Explain 0.00439