|
#
|
Concept name
|
Type
|
Relation
|
Support
|
Score
|
|
1
|
PUB domain
|
Domain
|
Known
|
Explain
|
78.83590
|
|
2
|
Ribonuclease L
|
Domain
|
Known
|
Explain
|
70.50952
|
|
3
|
UBXN6 gene
|
Gene
|
Known
|
Explain
|
46.01970
|
|
4
|
NGLY1 gene
|
Gene
|
Known
|
Explain
|
40.91519
|
|
5
|
ERN2 gene
|
Gene
|
Known
|
Explain
|
35.08755
|
|
6
|
ERN1 gene
|
Gene
|
Known
|
Explain
|
24.35963
|
|
7
|
endoribonuclease activity, producing 5'-phosphomonoesters
|
Function
|
Inferred
|
Explain
|
3.86745
|
|
8
|
RNF31 gene
|
Gene
|
Inferred
|
Explain
|
0.67599
|
|
9
|
mRNA processing
|
Function
|
Inferred
|
Explain
|
0.40805
|
|
10
|
UBX
|
Domain
|
Inferred
|
Explain
|
0.35785
|
|
11
|
PLAA gene
|
Gene
|
Inferred
|
Explain
|
0.24729
|
|
12
|
Protein Binding
|
Function
|
Known
|
Explain
|
0.24069
|
|
13
|
Ribonuclease Z
|
Domain
|
Inferred
|
Explain
|
0.21666
|
|
14
|
Ribonuclease Z putative
|
Domain
|
Inferred
|
Explain
|
0.19624
|
|
15
|
SYVN1 gene
|
Gene
|
Inferred
|
Explain
|
0.19328
|
|
16
|
VCPIP1 gene
|
Gene
|
Inferred
|
Explain
|
0.17761
|
|
17
|
Pyrrolo-quinoline quinone beta-propeller repeat
|
Domain
|
Inferred
|
Explain
|
0.16816
|
|
18
|
HERPUD1 gene
|
Gene
|
Inferred
|
Explain
|
0.16462
|
|
19
|
rRNA catabolic process
|
Function
|
Inferred
|
Explain
|
0.12304
|
|
20
|
Quinonprotein alcohol dehydrogenase-like
|
Domain
|
Inferred
|
Explain
|
0.12199
|
|
21
|
PNGase F activity
|
Function
|
Inferred
|
Explain
|
0.11574
|
|
22
|
Protein of unknown function PAW
|
Domain
|
Inferred
|
Explain
|
0.11568
|
|
23
|
KEGG:hsa04141
|
Pathway
|
Inferred
|
Explain
|
0.10447
|
|
24
|
ELAC1 gene
|
Gene
|
Inferred
|
Explain
|
0.10282
|
|
25
|
tRNA 3'-trailer cleavage
|
Function
|
Inferred
|
Explain
|
0.10098
|
|
26
|
RNA lariat debranching enzyme activity
|
Function
|
Inferred
|
Explain
|
0.09793
|
|
27
|
endoribonuclease activity, cleaving siRNA-paired mRNA
|
Function
|
Inferred
|
Explain
|
0.09096
|
|
28
|
endoribonuclease activity
|
Function
|
Inferred
|
Explain
|
0.07678
|
|
29
|
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
|
Function
|
Inferred
|
Explain
|
0.07538
|
|
30
|
ribonuclease III activity
|
Function
|
Inferred
|
Explain
|
0.06903
|
|
31
|
VCP gene
|
Gene
|
Inferred
|
Explain
|
0.06698
|
|
32
|
Transglutaminase-like
|
Domain
|
Inferred
|
Explain
|
0.06480
|
|
33
|
Microtubule-Organizing Center
|
Component
|
Inferred
|
Explain
|
0.05641
|
|
34
|
RNASEL gene
|
Gene
|
Inferred
|
Explain
|
0.03811
|
|
35
|
ribonuclease H activity
|
Function
|
Inferred
|
Explain
|
0.03121
|
|
36
|
endonuclease activity
|
Function
|
Inferred
|
Explain
|
0.03043
|
|
37
|
Glycoprotein Degradation Pathway
|
Function
|
Inferred
|
Explain
|
0.02933
|
|
38
|
RNase P activity
|
Function
|
Inferred
|
Explain
|
0.02448
|
|
39
|
RAD23B gene
|
Gene
|
Inferred
|
Explain
|
0.02364
|
|
40
|
DBR1 gene
|
Gene
|
Inferred
|
Explain
|
0.02356
|
|
41
|
Cell Cycle Arrest
|
Function
|
Inferred
|
Explain
|
0.02179
|
|
42
|
Protamine
|
Compound
|
Inferred
|
Explain
|
0.02169
|
|
43
|
O-Phosphoprotamine
|
Compound
|
Inferred
|
Explain
|
0.02169
|
|
44
|
Induction of Apoptosis
|
Function
|
Inferred
|
Explain
|
0.01682
|
|
45
|
Serine/threonine protein kinase, active site
|
Domain
|
Inferred
|
Explain
|
0.01657
|
|
46
|
Serine/threonine protein kinase-related
|
Domain
|
Inferred
|
Explain
|
0.01554
|
|
47
|
Galactose-binding like
|
Domain
|
Inferred
|
Explain
|
0.01354
|
|
48
|
cellular_component
|
Component
|
Inferred
|
Explain
|
0.01326
|
|
49
|
Ribonuclease III, bacterial
|
Domain
|
Inferred
|
Explain
|
0.01274
|
|
50
|
hydrolase activity
|
Function
|
Inferred
|
Explain
|
0.01235
|
|
51
|
molecular_function
|
Function
|
Inferred
|
Explain
|
0.01228
|
|
52
|
Protein kinase, core
|
Domain
|
Inferred
|
Explain
|
0.01217
|
|
53
|
protein serine/threonine kinase activity
|
Function
|
Inferred
|
Explain
|
0.01213
|
|
54
|
Physiological Processes
|
Function
|
Inferred
|
Explain
|
0.01180
|
|
55
|
Forskolin
|
Compound
|
Inferred
|
Explain
|
0.01145
|
|
56
|
Protein kinase-like
|
Domain
|
Inferred
|
Explain
|
0.01123
|
|
57
|
Cytoskeleton
|
Component
|
Inferred
|
Explain
|
0.01122
|
|
58
|
biological adaptation to stress
|
Function
|
Inferred
|
Explain
|
0.01070
|
|
59
|
Phosphoproteins
|
Compound
|
Inferred
|
Explain
|
0.01065
|
|
60
|
magnesium ion binding
|
Function
|
Inferred
|
Explain
|
0.01022
|
|
61
|
protein amino acid phosphorylation
|
Function
|
Inferred
|
Explain
|
0.01013
|
|
62
|
Cytoplasm
|
Component
|
Inferred
|
Explain
|
0.00985
|
|
63
|
tRNA 3'-end processing
|
Function
|
Inferred
|
Explain
|
0.00969
|
|
64
|
activation of signaling protein activity involved in unfolded protein response
|
Function
|
Inferred
|
Explain
|
0.00902
|
|
65
|
Adenosine Diphosphate
|
Compound
|
Inferred
|
Explain
|
0.00862
|
|
66
|
Pyrrolo-quinoline quinone repeat
|
Domain
|
Inferred
|
Explain
|
0.00816
|
|
67
|
rRNA metabolic process
|
Function
|
Inferred
|
Explain
|
0.00812
|
|
68
|
nuclear polyadenylation-dependent rRNA catabolic process
|
Function
|
Inferred
|
Explain
|
0.00801
|
|
69
|
Cell Nucleus
|
Component
|
Inferred
|
Explain
|
0.00797
|
|
70
|
Adenosine Triphosphate
|
Compound
|
Inferred
|
Explain
|
0.00770
|
|
71
|
Proteins
|
Compound
|
Inferred
|
Explain
|
0.00768
|
|
72
|
Beta-lactamase-like
|
Domain
|
Inferred
|
Explain
|
0.00759
|
|
73
|
negative regulation of transcription
|
Function
|
Inferred
|
Explain
|
0.00698
|
|
74
|
Endoplasmic reticulum, membrane
|
Component
|
Inferred
|
Explain
|
0.00697
|
|
75
|
Apoptosis
|
Function
|
Inferred
|
Explain
|
0.00696
|
|
76
|
EIF2C2 gene
|
Gene
|
Inferred
|
Explain
|
0.00689
|
|
77
|
PQQ-dependent dehydrogenase, methanol/ethanol family
|
Domain
|
Inferred
|
Explain
|
0.00631
|
|
78
|
PQQ-dependent membrane bound dehydrogenase, glucose/quinate/shikimate related
|
Domain
|
Inferred
|
Explain
|
0.00614
|
|
79
|
Endoplasmic Reticulum
|
Component
|
Inferred
|
Explain
|
0.00600
|
|
80
|
nucleotide binding
|
Function
|
Inferred
|
Explain
|
0.00589
|
|
81
|
Outer membrane assembly lipoprotein YfgL
|
Domain
|
Inferred
|
Explain
|
0.00584
|
|
82
|
UBXN8 gene
|
Gene
|
Inferred
|
Explain
|
0.00557
|
|
83
|
CD40 signaling pathway
|
Function
|
Inferred
|
Explain
|
0.00555
|
|
84
|
Metribolone
|
Compound
|
Inferred
|
Explain
|
0.00553
|
|
85
|
PQQ-dependent enzyme, C-terminal
|
Domain
|
Inferred
|
Explain
|
0.00520
|
|
86
|
Quinoprotein dehydrogenase, conserved site
|
Domain
|
Inferred
|
Explain
|
0.00516
|
|
87
|
Arsenic
|
Compound
|
Inferred
|
Explain
|
0.00507
|
|
88
|
transferase activity
|
Function
|
Inferred
|
Explain
|
0.00504
|
|
89
|
ATP binding
|
Function
|
Inferred
|
Explain
|
0.00498
|
|
90
|
Zinc finger, C6HC-type
|
Domain
|
Inferred
|
Explain
|
0.00497
|
|
91
|
TAOK3 gene
|
Gene
|
Inferred
|
Explain
|
0.00428
|
|
92
|
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
|
Function
|
Inferred
|
Explain
|
0.00424
|
|
93
|
Metal Ion Binding
|
Function
|
Inferred
|
Explain
|
0.00412
|
|
94
|
endodeoxyribonuclease activity, producing 5'-phosphomonoesters
|
Function
|
Inferred
|
Explain
|
0.00372
|
|
95
|
Cyclosporine
|
Compound
|
Inferred
|
Explain
|
0.00371
|
|
96
|
ncRNA catabolic process
|
Function
|
Inferred
|
Explain
|
0.00349
|
|
97
|
DEDD2 gene
|
Gene
|
Inferred
|
Explain
|
0.00346
|
|
98
|
Inner nuclear membrane
|
Component
|
Inferred
|
Explain
|
0.00340
|
|
99
|
UBX , Rep6
|
Domain
|
Inferred
|
Explain
|
0.00326
|
|
100
|
Unfolded Protein Response
|
Function
|
Inferred
|
Explain
|
0.00323
|