activation of phospholipase C activity by dopamine receptor signaling pathway

Function • C2262929

Definition

The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate. [GOC:dph, GOC:tb, PMID:12675914]

Synonyms

activation of phospholipase C activity by dopamine receptor signaling pathway • activation of phospholipase C activity by dopamine receptor signalling pathway • dopamine receptor, phospholipase C activating pathway • phospholipase C-activating dopamine receptor signaling pathway

Linked items^?Related concepts, ordered by their global importance in the network.
DRD2 gene GNAQ gene DRD1 gene DRD5 gene GNA11 gene GNA15 gene activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GNA14 gene dopamine receptor signaling pathway consequence of signal transmission

Related concepts

# Concept name Type Relation Support Score

1 consequence of signal transmission Function Known Explain 22.78568

2 dopamine receptor signaling pathway Function Known Explain 17.92891

3 GNA14 gene Gene Known Explain 10.22063

4 GNA15 gene Gene Known Explain 7.65230

5 GNA11 gene Gene Known Explain 6.38499

6 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger Function Known Explain 6.37225

7 DRD5 gene Gene Known Explain 4.34287

8 GNAQ gene Gene Known Explain 3.81326

9 DRD1 gene Gene Known Explain 2.82102

10 DRD2 gene Gene Known Explain 1.80874

11 inhibition of adenylate cyclase activity by dopamine receptor signaling pathway Function Inferred Explain 1.16607

12 activation of adenylate cyclase activity by dopamine receptor signaling pathway Function Inferred Explain 1.14758

13 regulation of gene expression as a consequence of signal transmission Function Inferred Explain 0.43381

14 D1 dopamine receptor-interacting, calcyon Domain Inferred Explain 0.42754

15 CALY gene Gene Inferred Explain 0.32411

16 signaling process Function Inferred Explain 0.28663

17 KLF16 gene Gene Inferred Explain 0.28052

18 G-protein alpha subunit, group Q Domain Inferred Explain 0.27952

19 Guanine nucleotide binding protein (G-protein), alpha subunit Domain Inferred Explain 0.19814

20 G protein alpha subunit, helical insertion Domain Inferred Explain 0.19024

21 G-protein beta/gamma-subunit binding Function Inferred Explain 0.16164

22 guanyl nucleotide binding Function Inferred Explain 0.15211

23 RGS9 gene Gene Inferred Explain 0.15029

24 DRD4 gene Gene Inferred Explain 0.14313

25 extrinsic to internal side of plasma membrane Component Inferred Explain 0.13455

26 GNAO1 gene Gene Inferred Explain 0.11005

27 heterotrimeric G-protein complex location Component Inferred Explain 0.10925

28 protein amino acid ADP-ribosylation Function Inferred Explain 0.09283

29 G-protein signaling, coupled to cAMP nucleotide second messenger Function Inferred Explain 0.08936

30 CHRM2 gene Gene Inferred Explain 0.06884

31 activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway Function Inferred Explain 0.05691

32 CXCR2 gene Gene Inferred Explain 0.05104

33 CXCR1 gene Gene Inferred Explain 0.05085

34 G-protein coupled receptor protein signaling pathway Function Inferred Explain 0.04961

35 G-protein-coupled receptor binding Function Inferred Explain 0.04566

36 KEGG:hsa05142 Pathway Inferred Explain 0.04425

37 Calcium signaling pathway - Homo sapiens (human) Pathway Inferred Explain 0.03887

38 KEGG:hsa05146 Pathway Inferred Explain 0.03708

39 GTP catabolic process Function Inferred Explain 0.03620

40 DRD3 gene Gene Inferred Explain 0.03586

41 HTT gene Gene Inferred Explain 0.03422

42 ADCY5 gene Gene Inferred Explain 0.03055

43 regulation of melanocyte differentiation Function Inferred Explain 0.02847

44 GNAL gene Gene Inferred Explain 0.02765

45 signal transducer activity Function Inferred Explain 0.02659

46 OPRL1 gene Gene Inferred Explain 0.02621

47 TTC1 gene Gene Inferred Explain 0.02607

48 LTB4R gene Gene Inferred Explain 0.02588

49 activation of adenylate cyclase activity by G-protein signaling pathway Function Inferred Explain 0.02573

50 GTPase activity Function Inferred Explain 0.02462

51 ADRB2 gene Gene Inferred Explain 0.02392

52 inhibition of adenylate cyclase activity by G-protein signaling pathway Function Inferred Explain 0.02344

53 GRM4 gene Gene Inferred Explain 0.02238

54 Platelet Activation Function Inferred Explain 0.02200

55 activation of phospholipase C activity Function Inferred Explain 0.02185

56 GRM2 gene Gene Inferred Explain 0.02128

57 pigmentation during development Function Inferred Explain 0.02041

58 dopamine receptor activity, coupled via Gs Function Inferred Explain 0.02021

59 OPRM1 gene Gene Inferred Explain 0.01942

60 PTGIR gene Gene Inferred Explain 0.01942

61 regulation of action potential Function Inferred Explain 0.01939

62 GNAZ gene Gene Inferred Explain 0.01818

63 generation of a signal involved in cell-cell signaling Function Inferred Explain 0.01673

64 termination of signal transduction Function Inferred Explain 0.01621

65 SSTR2 gene Gene Inferred Explain 0.01580

66 GTP Binding Function Inferred Explain 0.01510

67 dopamine receptor activity Function Inferred Explain 0.01477

68 initiation of signal transduction Function Inferred Explain 0.01473

69 signal transmission Function Inferred Explain 0.01328

70 Blood coagulation Function Inferred Explain 0.01299

71 TBXA2R gene Gene Inferred Explain 0.01288

72 Cell membrane Component Inferred Explain 0.01278

73 OPRD1 gene Gene Inferred Explain 0.01272

74 dopamine receptor binding Function Inferred Explain 0.01272

75 Dopamine receptor Domain Inferred Explain 0.01248

76 GNA12 gene Gene Inferred Explain 0.01247

77 receptor recycling Function Inferred Explain 0.01240

78 Gap junction - Homo sapiens (human) Pathway Inferred Explain 0.01218

79 HRH4 gene Gene Inferred Explain 0.01195

80 RGS2 gene Gene Inferred Explain 0.01133

81 ADRA1B gene Gene Inferred Explain 0.01118

82 GNAI2 gene Gene Inferred Explain 0.01103

83 OPRK1 gene Gene Inferred Explain 0.01089

84 CCR1 gene Gene Inferred Explain 0.01088

85 Long-term depression - Homo sapiens (human) Pathway Inferred Explain 0.01087

86 GNAS gene Gene Inferred Explain 0.01078

87 GNA13 gene Gene Inferred Explain 0.01076

88 signal release Function Inferred Explain 0.01071

89 TSHR gene Gene Inferred Explain 0.01053

90 GNAI1 gene Gene Inferred Explain 0.01017

91 ADRBK1 gene Gene Inferred Explain 0.01004

92 GNAI3 gene Gene Inferred Explain 0.01003

93 GNAT3 gene Gene Inferred Explain 0.00994

94 Neuroactive ligand-receptor interaction - Homo sapiens (human) Pathway Inferred Explain 0.00992

95 CRHR1 gene Gene Inferred Explain 0.00932

96 synaptic transmission, dopaminergic Function Inferred Explain 0.00918

97 elevation of cytosolic calcium ion concentration Function Inferred Explain 0.00909

98 HTR2A gene Gene Inferred Explain 0.00907

99 EDNRB gene Gene Inferred Explain 0.00897

100 CNR2 gene Gene Inferred Explain 0.00870