Alzheimer disease, familial, type 3

Disease • C1843013

Synonyms

Alzheimer disease, familial, type 3 • AD3 • ALZHEIMER DISEASE 3, EARLY-ONSET • ALZHEIMER DISEASE, FAMILIAL, 3 • Alzheimer disease 3 • Alzheimer disease early onset type 3 • Alzheimer disease type 3

Linked items?Related concepts, ordered by their global importance in the network.

PSEN1 gene    Alzheimer's Disease    Early-onset    Paraparesis, Spastic    Apraxias   

Related concepts

# Concept name Type Relation Support Score
1 Apraxias Disease Known Explain 87.65152
2 Paraparesis, Spastic Disease Known Explain 57.40151
3 Early-onset Disease Known Explain 28.84872
4 Alzheimer's Disease Disease Known Explain 10.15650
5 Gait Apraxia Disease Inferred Explain 8.95435
6 PSEN1 gene Gene Known Explain 7.11235
7 Psychomotor Disorders Disease Inferred Explain 5.72655
8 Wieacker-Wolff syndrome Disease Inferred Explain 3.75695
9 Gait Disorders, Neurologic Disease Inferred Explain 3.36531
10 Neurobehavioral Manifestations Disease Inferred Explain 2.32751
11 FOXP2 gene Gene Inferred Explain 1.28707
12 Paraparesis Disease Inferred Explain 1.17985
13 BRANCHIAL MYOCLONUS WITH SPASTIC PARAPARESIS AND CEREBELLAR ATAXIA Disease Inferred Explain 1.04389
14 SPASTIC PARAPLEGIA 23 (disorder) Disease Inferred Explain 0.91048
15 SPASTIC PARAPARESIS AND DEAFNESS Disease Inferred Explain 0.88945
16 Troyer syndrome Disease Inferred Explain 0.82042
17 SPASTIC PARAPLEGIA 9, AUTOSOMAL DOMINANT (disorder) Disease Inferred Explain 0.77744
18 Gait Ataxia Disease Inferred Explain 0.67456
19 Paresis Disease Inferred Explain 0.47049
20 Neurologic Manifestations Disease Inferred Explain 0.26564
21 Spastic Paraplegia Disease Inferred Explain 0.19543
22 PILI TORTI Disease Inferred Explain 0.13075
23 Harding ataxia Disease Inferred Explain 0.12048
24 LEPROSY, SUSCEPTIBILITY TO, 4 Disease Inferred Explain 0.11770
25 NEPHROTIC SYNDROME, TYPE 3 Disease Inferred Explain 0.11335
26 PARKINSON DISEASE 6, AUTOSOMAL RECESSIVE EARLY-ONSET Disease Inferred Explain 0.11074
27 CATARACT, AUTOSOMAL RECESSIVE, EARLY-ONSET, PULVERULENT Disease Inferred Explain 0.11024
28 CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 5 Disease Inferred Explain 0.10901
29 SARCOIDOSIS, EARLY-ONSET Disease Inferred Explain 0.10829
30 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE Disease Inferred Explain 0.10676
31 HUNTINGTON DISEASE-LIKE 1 Disease Inferred Explain 0.10622
32 Waisman syndrome Disease Inferred Explain 0.10128
33 Milroy Disease Disease Inferred Explain 0.09874
34 Welander Distal Myopathy Disease Inferred Explain 0.09803
35 Corneal dystrophy, Fuchs' endothelial, 1 Disease Inferred Explain 0.09781
36 HYPERTENSION, EARLY-ONSET, AUTOSOMAL DOMINANT, WITH SEVERE EXACERBATION IN PREGNANCY Disease Inferred Explain 0.09778
37 SPINOCEREBELLAR ATAXIA, X-LINKED 2 Disease Inferred Explain 0.09394
38 Childhood onset Disease Inferred Explain 0.09049
39 Vitiligo Disease Inferred Explain 0.08699
40 Cerebellar Ataxia Disease Inferred Explain 0.08478
41 Congenital contractures Other Inferred Explain 0.08445
42 SPINOCEREBELLAR ATAXIA 29 Disease Inferred Explain 0.08384
43 ATAXIA, EARLY-ONSET, WITH OCULOMOTOR APRAXIA AND HYPOALBUMINEMIA Disease Inferred Explain 0.07938
44 PROOPIOMELANOCORTIN DEFICIENCY Disease Inferred Explain 0.07883
45 Agitation Disease Inferred Explain 0.07744
46 Vitelliform Macular Dystrophy Disease Inferred Explain 0.06991
47 Ataxia Disease Inferred Explain 0.05694
48 Oculovestibuloauditory syndrome Disease Inferred Explain 0.04671
49 SPG20 gene Gene Inferred Explain 0.04342
50 Gastroesophageal reflux disease Disease Inferred Explain 0.04024
51 Contracture Other Inferred Explain 0.03624
52 MILES-CARPENTER X-LINKED MENTAL RETARDATION SYNDROME Disease Inferred Explain 0.02465
53 Pili torti developmental delay neurological abnormalities Disease Inferred Explain 0.02449
54 Pili torti-deafness syndrome Disease Inferred Explain 0.02254
55 Coronary Artery Disease Disease Inferred Explain 0.01646
56 Foot Other Inferred Explain 0.01644
57 Short stature Disease Inferred Explain 0.01638
58 Muscular Atrophy Disease Inferred Explain 0.01636
59 Parkinsonian Disorders Disease Inferred Explain 0.01497
60 PSEN2 gene Gene Inferred Explain 0.01473
61 Perceptual Disorders Disease Inferred Explain 0.01460
62 Leprosy Disease Inferred Explain 0.01412
63 Isotretinoin Compound Inferred Explain 0.01386
64 Deafness Disease Inferred Explain 0.01356
65 Complete Hearing Loss Disease Inferred Explain 0.01352
66 Lethargy Disease Inferred Explain 0.01239
67 Confusion Disease Inferred Explain 0.01130
68 Diurnal fluctuation Disease Inferred Explain 0.01021
69 Consciousness Disorders Disease Inferred Explain 0.01004
70 Sarcoidosis Disease Inferred Explain 0.00999
71 Communication impairment Disease Inferred Explain 0.00999
72 NCSTN gene Gene Inferred Explain 0.00996
73 2,3',4,4',5-pentachlorobiphenyl Compound Inferred Explain 0.00955
74 Catatonia Disease Inferred Explain 0.00871
75 Mental Retardation Disease Inferred Explain 0.00844
76 Prion Diseases Disease Inferred Explain 0.00822
77 PCB 156 Compound Inferred Explain 0.00790
78 COL8A2 gene Gene Inferred Explain 0.00786
79 Nephrotic Syndrome Disease Inferred Explain 0.00779
80 Coronary heart disease Disease Inferred Explain 0.00776
81 smooth endoplasmic reticulum calcium ion homeostasis Function Inferred Explain 0.00765
82 Lymphedema Disease Inferred Explain 0.00756
83 Parkinson Disease Disease Inferred Explain 0.00731
84 endoplasmic reticulum calcium ion homeostasis Function Inferred Explain 0.00719
85 CEREBELLAR VERMIS APLASIA WITH ASSOCIATED FEATURES SUGGESTING SMITH-LEMLI-OPITZ SYNDROME AND MECKEL SYNDROME Disease Inferred Explain 0.00702
86 RAI1 gene Gene Inferred Explain 0.00679
87 FLT4 gene Gene Inferred Explain 0.00675
88 Aplasia, NOS Disease Inferred Explain 0.00668
89 LTA gene Gene Inferred Explain 0.00657
90 Cajal-Retzius cell differentiation Function Inferred Explain 0.00644
91 Nonprogressive Disease Inferred Explain 0.00642
92 Memory Disorders Disease Inferred Explain 0.00634
93 BACE1 gene Gene Inferred Explain 0.00622
94 CHRNA7 gene Gene Inferred Explain 0.00619
95 APH1A gene Gene Inferred Explain 0.00600
96 regulation of resting membrane potential Function Inferred Explain 0.00595
97 PSENEN gene Gene Inferred Explain 0.00566
98 membrane protein intracellular domain proteolysis Function Inferred Explain 0.00566
99 Arima syndrome Disease Inferred Explain 0.00560
100 Cataract Adverse Event Disease Inferred Explain 0.00539