|
erythrocyte maturation
|
Function • C1523887
Definition
A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. [GOC:devbiol, GOC:jl]
Synonyms
erythrocyte maturation • red blood cell maturation • RBC maturation
|
|
TIMP1 gene
G6PD gene
EPO gene
EPB42 gene
Cell Maturation
MAEA gene
HBZ gene
|
Related concepts
|
#
|
Concept name
|
Type
|
Relation
|
Support
|
Score
|
|
1
|
HBZ gene
|
Gene
|
Known
|
Explain
|
41.90199
|
|
2
|
MAEA gene
|
Gene
|
Known
|
Explain
|
26.71742
|
|
3
|
Cell Maturation
|
Function
|
Known
|
Explain
|
19.43721
|
|
4
|
EPB42 gene
|
Gene
|
Known
|
Explain
|
16.30665
|
|
5
|
EPO gene
|
Gene
|
Known
|
Explain
|
8.87128
|
|
6
|
TIMP1 gene
|
Gene
|
Known
|
Explain
|
8.24147
|
|
7
|
G6PD gene
|
Gene
|
Known
|
Explain
|
7.87084
|
|
8
|
enucleate erythrocyte development
|
Function
|
Inferred
|
Explain
|
0.29343
|
|
9
|
hemoglobin complex
|
Component
|
Inferred
|
Explain
|
0.23478
|
|
10
|
oxygen transporter activity
|
Function
|
Inferred
|
Explain
|
0.23007
|
|
11
|
CTLH, C-terminal to LisH motif
|
Domain
|
Inferred
|
Explain
|
0.20417
|
|
12
|
oxygen transport
|
Function
|
Inferred
|
Explain
|
0.20323
|
|
13
|
actomyosin contractile ring
|
Component
|
Inferred
|
Explain
|
0.13905
|
|
14
|
negative regulation of myeloid cell apoptosis
|
Function
|
Inferred
|
Explain
|
0.13741
|
|
15
|
oxygen binding activity
|
Function
|
Inferred
|
Explain
|
0.12295
|
|
16
|
HBB gene
|
Gene
|
Inferred
|
Explain
|
0.11408
|
|
17
|
LisH dimerisation motif
|
Domain
|
Inferred
|
Explain
|
0.09276
|
|
18
|
erythrocyte development
|
Function
|
Inferred
|
Explain
|
0.07183
|
|
19
|
MYOC gene
|
Gene
|
Inferred
|
Explain
|
0.05887
|
|
20
|
regulation of mitotic cell cycle
|
Function
|
Inferred
|
Explain
|
0.05744
|
|
21
|
FGFR3 gene
|
Gene
|
Inferred
|
Explain
|
0.04517
|
|
22
|
heme binding
|
Function
|
Inferred
|
Explain
|
0.03886
|
|
23
|
Nuclear Matrix
|
Component
|
Inferred
|
Explain
|
0.03649
|
|
24
|
Asbestos
|
Compound
|
Inferred
|
Explain
|
0.03143
|
|
25
|
negative regulation of transcription from RNA polymerase II promoter
|
Function
|
Inferred
|
Explain
|
0.02923
|
|
26
|
oocyte construction
|
Function
|
Inferred
|
Explain
|
0.02917
|
|
27
|
Spindle
|
Component
|
Inferred
|
Explain
|
0.02741
|
|
28
|
cytoskeleton organization
|
Function
|
Inferred
|
Explain
|
0.02600
|
|
29
|
neuron maturation
|
Function
|
Inferred
|
Explain
|
0.02549
|
|
30
|
IKBKG gene
|
Gene
|
Inferred
|
Explain
|
0.02242
|
|
31
|
epithelial cell maturation
|
Function
|
Inferred
|
Explain
|
0.02216
|
|
32
|
Sperm Capacitation
|
Function
|
Inferred
|
Explain
|
0.01713
|
|
33
|
BHLHA15 gene
|
Gene
|
Inferred
|
Explain
|
0.01647
|
|
34
|
developmental maturation
|
Function
|
Inferred
|
Explain
|
0.01492
|
|
35
|
oocyte maturation
|
Function
|
Inferred
|
Explain
|
0.01451
|
|
36
|
HES5 gene
|
Gene
|
Inferred
|
Explain
|
0.01402
|
|
37
|
hemoglobin metabolic process
|
Function
|
Inferred
|
Explain
|
0.01329
|
|
38
|
Transglutaminase, conserved site
|
Domain
|
Inferred
|
Explain
|
0.01318
|
|
39
|
Transglutaminase, C-terminal
|
Domain
|
Inferred
|
Explain
|
0.01258
|
|
40
|
Transglutaminase-like
|
Domain
|
Inferred
|
Explain
|
0.01242
|
|
41
|
LHX6 gene
|
Gene
|
Inferred
|
Explain
|
0.01209
|
|
42
|
Hydralazine
|
Compound
|
Inferred
|
Explain
|
0.01198
|
|
43
|
SPINK7 gene
|
Gene
|
Inferred
|
Explain
|
0.01191
|
|
44
|
Transglutaminase, N-terminal
|
Domain
|
Inferred
|
Explain
|
0.01168
|
|
45
|
Erythropoietin
|
Domain
|
Inferred
|
Explain
|
0.01166
|
|
46
|
GDF11 gene
|
Gene
|
Inferred
|
Explain
|
0.01130
|
|
47
|
protein-glutamine gamma-glutamyltransferase activity
|
Function
|
Inferred
|
Explain
|
0.01093
|
|
48
|
Cell division
|
Function
|
Inferred
|
Explain
|
0.01073
|
|
49
|
cellular developmental process
|
Function
|
Inferred
|
Explain
|
0.01033
|
|
50
|
iron ion homeostasis
|
Function
|
Inferred
|
Explain
|
0.00999
|
|
51
|
Biological Transport
|
Function
|
Inferred
|
Explain
|
0.00998
|
|
52
|
CNO gene
|
Gene
|
Inferred
|
Explain
|
0.00994
|
|
53
|
actin binding
|
Function
|
Inferred
|
Explain
|
0.00983
|
|
54
|
RFX3 gene
|
Gene
|
Inferred
|
Explain
|
0.00969
|
|
55
|
ion homeostasis
|
Function
|
Inferred
|
Explain
|
0.00963
|
|
56
|
kojic acid
|
Compound
|
Inferred
|
Explain
|
0.00962
|
|
57
|
PLP1 gene
|
Gene
|
Inferred
|
Explain
|
0.00955
|
|
58
|
EPB49 gene
|
Gene
|
Inferred
|
Explain
|
0.00915
|
|
59
|
methylselenic acid
|
Compound
|
Inferred
|
Explain
|
0.00906
|
|
60
|
IL21 gene
|
Gene
|
Inferred
|
Explain
|
0.00897
|
|
61
|
Globin
|
Domain
|
Inferred
|
Explain
|
0.00854
|
|
62
|
SOX8 gene
|
Gene
|
Inferred
|
Explain
|
0.00829
|
|
63
|
Glucose-6-phosphate dehydrogenase
|
Domain
|
Inferred
|
Explain
|
0.00820
|
|
64
|
Cytoskeleton
|
Component
|
Inferred
|
Explain
|
0.00816
|
|
65
|
Calcium Valproate
|
Compound
|
Inferred
|
Explain
|
0.00808
|
|
66
|
erythropoietin receptor binding activity
|
Function
|
Inferred
|
Explain
|
0.00758
|
|
67
|
Glucose-6-phosphate dehydrogenase, active site
|
Domain
|
Inferred
|
Explain
|
0.00745
|
|
68
|
Cell Cycle
|
Function
|
Inferred
|
Explain
|
0.00730
|
|
69
|
FZD5 gene
|
Gene
|
Inferred
|
Explain
|
0.00730
|
|
70
|
Erythropoietin/thrombopoeitin, conserved site
|
Domain
|
Inferred
|
Explain
|
0.00723
|
|
71
|
Erythropoietin/thrombopoeitin
|
Domain
|
Inferred
|
Explain
|
0.00715
|
|
72
|
membrane fraction
|
Component
|
Inferred
|
Explain
|
0.00687
|
|
73
|
SOX10 gene
|
Gene
|
Inferred
|
Explain
|
0.00686
|
|
74
|
Metal Ion Binding
|
Function
|
Inferred
|
Explain
|
0.00676
|
|
75
|
Cortical cytoskeleton
|
Component
|
Inferred
|
Explain
|
0.00668
|
|
76
|
SLC4A2 gene
|
Gene
|
Inferred
|
Explain
|
0.00641
|
|
77
|
Spleen Development
|
Function
|
Inferred
|
Explain
|
0.00636
|
|
78
|
STX12 gene
|
Gene
|
Inferred
|
Explain
|
0.00624
|
|
79
|
Globin, subset
|
Domain
|
Inferred
|
Explain
|
0.00602
|
|
80
|
PTH1R gene
|
Gene
|
Inferred
|
Explain
|
0.00594
|
|
81
|
glucose-6-phosphate dehydrogenase activity
|
Function
|
Inferred
|
Explain
|
0.00588
|
|
82
|
contractile ring
|
Component
|
Inferred
|
Explain
|
0.00588
|
|
83
|
IPR022674
|
Domain
|
Inferred
|
Explain
|
0.00570
|
|
84
|
HBQ1 gene
|
Gene
|
Inferred
|
Explain
|
0.00567
|
|
85
|
Cytoplasm
|
Component
|
Inferred
|
Explain
|
0.00550
|
|
86
|
IPR022675
|
Domain
|
Inferred
|
Explain
|
0.00549
|
|
87
|
ribose phosphate biosynthetic process
|
Function
|
Inferred
|
Explain
|
0.00541
|
|
88
|
Cell Adhesion
|
Function
|
Inferred
|
Explain
|
0.00540
|
|
89
|
hemoglobin biosynthetic process
|
Function
|
Inferred
|
Explain
|
0.00540
|
|
90
|
D-Glucono-1,5-lactone 6-phosphate
|
Compound
|
Inferred
|
Explain
|
0.00537
|
|
91
|
Haemoglobin, alpha
|
Domain
|
Inferred
|
Explain
|
0.00535
|
|
92
|
Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
|
Domain
|
Inferred
|
Explain
|
0.00517
|
|
93
|
Haemoglobin, beta
|
Domain
|
Inferred
|
Explain
|
0.00512
|
|
94
|
HBE1 gene
|
Gene
|
Inferred
|
Explain
|
0.00489
|
|
95
|
HES1 gene
|
Gene
|
Inferred
|
Explain
|
0.00480
|
|
96
|
HBG2 gene
|
Gene
|
Inferred
|
Explain
|
0.00471
|
|
97
|
Tissue inhibitor of metalloprotease 1
|
Domain
|
Inferred
|
Explain
|
0.00469
|
|
98
|
2,2'-azobis(2-amidinopropane)
|
Compound
|
Inferred
|
Explain
|
0.00466
|
|
99
|
RUNX2 gene
|
Gene
|
Inferred
|
Explain
|
0.00465
|
|
100
|
ANK2 gene
|
Gene
|
Inferred
|
Explain
|
0.00459
|
|