|
#
|
Concept name
|
Type
|
Relation
|
Support
|
Score
|
|
1
|
autosomal recessive hypophosphatemic bone disease
|
Disease
|
Known
|
Explain
|
8.11359
|
|
2
|
cellular phosphate ion homeostasis
|
Function
|
Known
|
Explain
|
6.95295
|
|
3
|
sodium-dependent phosphate transmembrane transporter activity
|
Function
|
Known
|
Explain
|
6.17164
|
|
4
|
response to magnesium ion
|
Function
|
Known
|
Explain
|
5.94741
|
|
5
|
sodium:phosphate symporter activity
|
Function
|
Known
|
Explain
|
4.51703
|
|
6
|
phosphate transport
|
Function
|
Known
|
Explain
|
3.19916
|
|
7
|
Sodium
|
Compound
|
Known
|
Explain
|
3.11649
|
|
8
|
response to nutrient levels
|
Function
|
Known
|
Explain
|
2.69066
|
|
9
|
brush border membrane
|
Component
|
Known
|
Explain
|
2.51305
|
|
10
|
PDZK1 gene
|
Gene
|
Known
|
Explain
|
1.66838
|
|
11
|
Hypophosphatemic Rickets
|
Disease
|
Inferred
|
Explain
|
1.16049
|
|
12
|
symporter activity
|
Function
|
Known
|
Explain
|
0.85228
|
|
13
|
sodium ion transport
|
Function
|
Known
|
Explain
|
0.64011
|
|
14
|
Hypercalciuria
|
Disease
|
Inferred
|
Explain
|
0.63196
|
|
15
|
Apical plasma membrane
|
Component
|
Known
|
Explain
|
0.61600
|
|
16
|
SLC34A2 gene
|
Gene
|
Inferred
|
Explain
|
0.52357
|
|
17
|
cellular di-, tri-valent inorganic anion homeostasis
|
Function
|
Inferred
|
Explain
|
0.49408
|
|
18
|
phosphate ion homeostasis
|
Function
|
Inferred
|
Explain
|
0.39538
|
|
19
|
Cytoplasmic Vesicles
|
Component
|
Known
|
Explain
|
0.37917
|
|
20
|
Orthophosphate
|
Compound
|
Known
|
Explain
|
0.33117
|
|
21
|
Ion Transport
|
Function
|
Known
|
Explain
|
0.24428
|
|
22
|
GCM2 gene
|
Gene
|
Inferred
|
Explain
|
0.20499
|
|
23
|
SLC34A1 gene
|
Gene
|
Inferred
|
Explain
|
0.20438
|
|
24
|
Transmembrane Transport
|
Function
|
Known
|
Explain
|
0.19581
|
|
25
|
di-, tri-valent inorganic anion homeostasis
|
Function
|
Inferred
|
Explain
|
0.15100
|
|
26
|
cellular response to magnesium ion
|
Function
|
Inferred
|
Explain
|
0.13517
|
|
27
|
SLC17A7 gene
|
Gene
|
Inferred
|
Explain
|
0.13169
|
|
28
|
cellular sulfate ion homeostasis
|
Function
|
Inferred
|
Explain
|
0.11857
|
|
29
|
Na/Pi-cotransporter
|
Domain
|
Inferred
|
Explain
|
0.10838
|
|
30
|
phosphate transmembrane transporter activity
|
Function
|
Inferred
|
Explain
|
0.09981
|
|
31
|
SLC20A2 gene
|
Gene
|
Inferred
|
Explain
|
0.08969
|
|
32
|
sulfate ion homeostasis
|
Function
|
Inferred
|
Explain
|
0.08905
|
|
33
|
SLC17A1 gene
|
Gene
|
Inferred
|
Explain
|
0.08698
|
|
34
|
SLC20A1 gene
|
Gene
|
Inferred
|
Explain
|
0.06432
|
|
35
|
Cell membrane
|
Component
|
Known
|
Explain
|
0.06406
|
|
36
|
cellular anion homeostasis
|
Function
|
Inferred
|
Explain
|
0.06038
|
|
37
|
SLC9A3R1 gene
|
Gene
|
Inferred
|
Explain
|
0.05290
|
|
38
|
integral to membrane
|
Component
|
Known
|
Explain
|
0.04624
|
|
39
|
inorganic phosphate transmembrane transporter activity
|
Function
|
Inferred
|
Explain
|
0.04164
|
|
40
|
ENPP1 gene
|
Gene
|
Inferred
|
Explain
|
0.03909
|
|
41
|
SLC17A3 gene
|
Gene
|
Inferred
|
Explain
|
0.03860
|
|
42
|
sodium:inorganic phosphate symporter activity
|
Function
|
Inferred
|
Explain
|
0.03685
|
|
43
|
response to metal ion
|
Function
|
Inferred
|
Explain
|
0.03229
|
|
44
|
HYPOPHOSPHATEMIC RICKETS, AUTOSOMAL RECESSIVE, 1
|
Disease
|
Inferred
|
Explain
|
0.03004
|
|
45
|
HYPOPHOSPHATEMIC RICKETS, X-LINKED RECESSIVE
|
Disease
|
Inferred
|
Explain
|
0.02902
|
|
46
|
high affinity inorganic phosphate:sodium symporter activity
|
Function
|
Inferred
|
Explain
|
0.02834
|
|
47
|
anion homeostasis
|
Function
|
Inferred
|
Explain
|
0.02751
|
|
48
|
Autosomal dominant hypophosphatemic rickets
|
Other
|
Inferred
|
Explain
|
0.02724
|
|
49
|
SLC17A4 gene
|
Gene
|
Inferred
|
Explain
|
0.02423
|
|
50
|
TNFRSF11B gene
|
Gene
|
Inferred
|
Explain
|
0.02279
|
|
51
|
SLC5A1 gene
|
Gene
|
Inferred
|
Explain
|
0.02168
|
|
52
|
Periplasmic phosphate binding protein
|
Domain
|
Inferred
|
Explain
|
0.02111
|
|
53
|
SLC17A2 gene
|
Gene
|
Inferred
|
Explain
|
0.02086
|
|
54
|
Phosphate transport system permease protein 1
|
Domain
|
Inferred
|
Explain
|
0.02052
|
|
55
|
PLCG2 gene
|
Gene
|
Inferred
|
Explain
|
0.01949
|
|
56
|
Phosphate transport system permease protein 2
|
Domain
|
Inferred
|
Explain
|
0.01938
|
|
57
|
Familial hypophosphatemic bone disease
|
Disease
|
Inferred
|
Explain
|
0.01902
|
|
58
|
RYR2 gene
|
Gene
|
Inferred
|
Explain
|
0.01891
|
|
59
|
SCNN1D gene
|
Gene
|
Inferred
|
Explain
|
0.01856
|
|
60
|
Metals, Alkali
|
Compound
|
Inferred
|
Explain
|
0.01724
|
|
61
|
Phosphate transporter
|
Domain
|
Inferred
|
Explain
|
0.01670
|
|
62
|
Progressive ankylosis
|
Domain
|
Inferred
|
Explain
|
0.01604
|
|
63
|
NHEDC2 gene
|
Gene
|
Inferred
|
Explain
|
0.01601
|
|
64
|
Na-dependent inorganic phosphate cotransporter
|
Domain
|
Inferred
|
Explain
|
0.01572
|
|
65
|
Phosphate permease
|
Domain
|
Inferred
|
Explain
|
0.01539
|
|
66
|
ABC transporter, phosphate import, PstB
|
Domain
|
Inferred
|
Explain
|
0.01536
|
|
67
|
Phosphate ABC transporter, permease protein PstC
|
Domain
|
Inferred
|
Explain
|
0.01534
|
|
68
|
SLC5A6 gene
|
Gene
|
Inferred
|
Explain
|
0.01511
|
|
69
|
SLC5A8 gene
|
Gene
|
Inferred
|
Explain
|
0.01295
|
|
70
|
SLC28A2 gene
|
Gene
|
Inferred
|
Explain
|
0.01269
|
|
71
|
vacuolar phosphate transport
|
Function
|
Inferred
|
Explain
|
0.01260
|
|
72
|
Na/Pi co-transporter II-related
|
Domain
|
Inferred
|
Explain
|
0.01253
|
|
73
|
sodium ion transmembrane transporter activity
|
Function
|
Inferred
|
Explain
|
0.01218
|
|
74
|
anion:cation symporter activity
|
Function
|
Inferred
|
Explain
|
0.01209
|
|
75
|
SCNN1G gene
|
Gene
|
Inferred
|
Explain
|
0.01169
|
|
76
|
GRIN2B gene
|
Gene
|
Inferred
|
Explain
|
0.01167
|
|
77
|
SLC9A7 gene
|
Gene
|
Inferred
|
Explain
|
0.01160
|
|
78
|
CACNA1E gene
|
Gene
|
Inferred
|
Explain
|
0.01151
|
|
79
|
Hypophosphatemia
|
Disease
|
Inferred
|
Explain
|
0.01134
|
|
80
|
SCNN1B gene
|
Gene
|
Inferred
|
Explain
|
0.01090
|
|
81
|
KLK1 gene
|
Gene
|
Inferred
|
Explain
|
0.01070
|
|
82
|
SLC4A4 gene
|
Gene
|
Inferred
|
Explain
|
0.01053
|
|
83
|
SLC28A1 gene
|
Gene
|
Inferred
|
Explain
|
0.01042
|
|
84
|
KLK5 gene
|
Gene
|
Inferred
|
Explain
|
0.01005
|
|
85
|
THBS1 gene
|
Gene
|
Inferred
|
Explain
|
0.00918
|
|
86
|
SCNN1A gene
|
Gene
|
Inferred
|
Explain
|
0.00909
|
|
87
|
cellular response to metal ion
|
Function
|
Inferred
|
Explain
|
0.00887
|
|
88
|
SNCA gene
|
Gene
|
Inferred
|
Explain
|
0.00868
|
|
89
|
HYPOURICEMIA, HYPERCALCINURIA, AND DECREASED BONE DENSITY
|
Disease
|
Inferred
|
Explain
|
0.00839
|
|
90
|
SLC22A12 gene
|
Gene
|
Inferred
|
Explain
|
0.00838
|
|
91
|
Signal transduction response regulator, phosphate regulon transcriptional regulatory protein phoB
|
Domain
|
Inferred
|
Explain
|
0.00832
|
|
92
|
BDKRB1 gene
|
Gene
|
Inferred
|
Explain
|
0.00814
|
|
93
|
SLC9A1 gene
|
Gene
|
Inferred
|
Explain
|
0.00729
|
|
94
|
inorganic anion transport
|
Function
|
Inferred
|
Explain
|
0.00716
|
|
95
|
Membrane
|
Component
|
Inferred
|
Explain
|
0.00697
|
|
96
|
SLC8A1 gene
|
Gene
|
Inferred
|
Explain
|
0.00676
|
|
97
|
CCND1 gene
|
Gene
|
Inferred
|
Explain
|
0.00571
|
|
98
|
PDZK1P2 gene
|
Gene
|
Inferred
|
Explain
|
0.00565
|
|
99
|
Familial idiopathic hypercalciuria
|
Other
|
Inferred
|
Explain
|
0.00531
|
|
100
|
SLC9A3 gene
|
Gene
|
Inferred
|
Explain
|
0.00505
|