SLC12A1 gene

Gene • C1420090

Synonyms

SLC12A1 gene • SOLUTE CARRIER FAMILY 12 (SODIUM/POTASSIUM/CHLORIDE TRANSPORTER), MEMBER 1 • solute carrier family 12 (sodium/potassium/chloride transporters), member 1 • NKCC2 • SLC12A1 • SODIUM-POTASSIUM-CHLORIDE TRANSPORTER 2

Linked items?Related concepts, ordered by their global importance in the network.

integral to membrane    Cell membrane    Biological Transport    Transmembrane Transport    Ion Transport    membrane fraction    transporter activity    potassium ion transport    Apical plasma membrane    sodium ion transport    symporter activity    chloride transport    kidney development    STK39 gene    Excretory function    OXSR1 gene    chemical homeostasis    Bartter syndrome, antenatal type 1    sodium:potassium:chloride symporter activity   

Related concepts

# Concept name Type Relation Support Score
1 Bartter syndrome, antenatal type 1 Disease Known Explain 9.86022
2 sodium:potassium:chloride symporter activity Function Known Explain 9.02575
3 chemical homeostasis Function Known Explain 3.73043
4 OXSR1 gene Gene Known Explain 3.23608
5 STK39 gene Gene Known Explain 2.02831
6 Hypokalemic alkalosis Disease Inferred Explain 1.75071
7 Excretory function Function Known Explain 1.60999
8 kidney development Function Known Explain 1.43929
9 chloride transport Function Known Explain 1.18518
10 Bartter Disease Disease Inferred Explain 1.15636
11 symporter activity Function Known Explain 0.77475
12 Hypercalciuria Disease Inferred Explain 0.76512
13 Apical plasma membrane Component Known Explain 0.60134
14 sodium ion transport Function Known Explain 0.57263
15 Bartter syndrome, antenatal , type 2 Disease Inferred Explain 0.57000
16 HYPOKALEMIA, FAMILIAL Disease Inferred Explain 0.45209
17 potassium ion transport Function Known Explain 0.42248
18 transporter activity Function Known Explain 0.27745
19 membrane fraction Component Known Explain 0.25047
20 Ion Transport Function Known Explain 0.24362
21 cation:chloride symporter activity Function Inferred Explain 0.21718
22 Transmembrane Transport Function Known Explain 0.18797
23 SLC12A2 gene Gene Inferred Explain 0.14579
24 Biological Transport Function Known Explain 0.14024
25 KCNJ1 gene Gene Inferred Explain 0.08837
26 Cell membrane Component Known Explain 0.06267
27 Hypokalemia Disease Inferred Explain 0.06173
28 Hyperaldosteronism Disease Inferred Explain 0.05730
29 integral to membrane Component Known Explain 0.04883
30 Bartter syndrome, type 3 Disease Inferred Explain 0.04473
31 HYPOURICEMIA, HYPERCALCINURIA, AND DECREASED BONE DENSITY Disease Inferred Explain 0.04051
32 BARTTER SYNDROME, TYPE 4A Disease Inferred Explain 0.03778
33 carbohydrate homeostasis Function Inferred Explain 0.03177
34 gas homeostasis Function Inferred Explain 0.02765
35 regulation of viral protein levels in host cell Function Inferred Explain 0.02687
36 polyamine homeostasis Function Inferred Explain 0.02631
37 Familial idiopathic hypercalciuria Other Inferred Explain 0.02591
38 HYPERPARATHYROIDISM, NEONATAL SELF-LIMITED PRIMARY, WITH HYPERCALCIURIA Disease Inferred Explain 0.02312
39 cellular chemical homeostasis Function Inferred Explain 0.02250
40 chemical homeostasis within a tissue Function Inferred Explain 0.02234
41 autosomal recessive hypophosphatemic bone disease Disease Inferred Explain 0.02230
42 Renal Tubular Transport, Inborn Errors Disease Inferred Explain 0.02133
43 water homeostasis Function Inferred Explain 0.02019
44 PROTEINURIA, LOW MOLECULAR WEIGHT, WITH HYPERCALCIURIA AND NEPHROCALCINOSIS Disease Inferred Explain 0.01903
45 HYPOMAGNESEMIA 5, RENAL, WITH OCULAR INVOLVEMENT Disease Inferred Explain 0.01756
46 Hypouricemia Disease Inferred Explain 0.01581
47 ion homeostasis Function Inferred Explain 0.01482
48 UMOD gene Gene Inferred Explain 0.01448
49 Urological Manifestations Disease Inferred Explain 0.01371
50 Primary hypomagnesemia (disorder) Disease Inferred Explain 0.01352
51 SLC12A6 gene Gene Inferred Explain 0.01304
52 REN gene Gene Inferred Explain 0.01253
53 galactose homeostasis Function Inferred Explain 0.01019
54 lipid homeostasis Function Inferred Explain 0.01009
55 Glucocorticoid-remediable aldosteronism Disease Inferred Explain 0.01006
56 Adrenal Gland Hyperfunction Disease Inferred Explain 0.00995
57 SLC12A3 gene Gene Inferred Explain 0.00980
58 homeostatic process Function Inferred Explain 0.00979
59 SLC34A1 gene Gene Inferred Explain 0.00974
60 CLCNKB gene Gene Inferred Explain 0.00866
61 Genticin Compound Inferred Explain 0.00823
62 Membrane Component Inferred Explain 0.00794
63 IDUA gene Gene Inferred Explain 0.00769
64 Furosemide Compound Inferred Explain 0.00736
65 Na/K/Cl co-transporter superfamily Domain Inferred Explain 0.00719
66 Dinoprostone Compound Inferred Explain 0.00706
67 potassium:chloride symporter activity Function Inferred Explain 0.00675
68 SLC34A3 gene Gene Inferred Explain 0.00633
69 SLC12A4 gene Gene Inferred Explain 0.00596
70 SLC12A7 gene Gene Inferred Explain 0.00577
71 SLC12A5 gene Gene Inferred Explain 0.00557
72 Renal hypouricemia Disease Inferred Explain 0.00543
73 WNK4 gene Gene Inferred Explain 0.00503
74 sodium:chloride symporter activity Function Inferred Explain 0.00503
75 nitric oxide homeostasis Function Inferred Explain 0.00484
76 cellular galactose homeostasis Function Inferred Explain 0.00469
77 CLCNKA gene Gene Inferred Explain 0.00464
78 Chloride channel, voltage gated Domain Inferred Explain 0.00450
79 voltage-gated chloride channel activity Function Inferred Explain 0.00372
80 SLC12A9 gene Gene Inferred Explain 0.00369
81 CLCN5 gene Gene Inferred Explain 0.00368
82 integral to plasma membrane Component Inferred Explain 0.00357
83 voltage-gated ion channel activity Function Inferred Explain 0.00356
84 ADCY10 gene Gene Inferred Explain 0.00351
85 Hypophosphatemic Rickets Disease Inferred Explain 0.00343
86 Gitelman Syndrome Disease Inferred Explain 0.00340
87 Hypocalciuria Disease Inferred Explain 0.00339
88 cellular water homeostasis Function Inferred Explain 0.00335
89 oxygen homeostasis Function Inferred Explain 0.00333
90 positive regulation of viral protein levels in host cell Function Inferred Explain 0.00311
91 EIF5A2 gene Gene Inferred Explain 0.00311
92 negative regulation of viral protein levels in host cell Function Inferred Explain 0.00307
93 Neurotransmitter-gated ion-channel transmembrane region Domain Inferred Explain 0.00301
94 Natriuresis Function Inferred Explain 0.00300
95 chemical homeostasis within retina Function Inferred Explain 0.00295
96 Chloride channel, core Domain Inferred Explain 0.00292
97 voltage-gated potassium channel complex Component Inferred Explain 0.00276
98 Neurotransmitter-gated ion-channel, conserved site Domain Inferred Explain 0.00272
99 voltage-gated potassium channel activity Function Inferred Explain 0.00268
100 Neurotransmitter-gated ion-channel ligand-binding Domain Inferred Explain 0.00267