PKHD1 gene

Gene • C1418605

Synonyms

PKHD1 gene • ARPKD • FIBROCYSTIN • polycystic kidney and hepatic disease 1 (autosomal recessive) • tigmin • POLYDUCTIN • FCYT • POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 GENE • PKHD1

Linked items?Related concepts, ordered by their global importance in the network.

Protein Binding    integral to membrane    Membrane    receptor activity    pirinixic acid    Immunoglobulin-like fold    Arbutin    Apical plasma membrane    Cell-Cell Adhesion    Immunoglobulin E-set    kidney development    microtubule basal body    cilium assembly    Pectin lyase fold/virulence factor    Cell surface receptor IPT/TIG    CAMLG gene    homeostatic process    Parallel beta-helix repeat    Pectin lyase fold    negative regulation of cellular component movement   

Related concepts

# Concept name Type Relation Support Score
1 G8 domain Domain Known Explain 8.46284
2 anchored to external side of plasma membrane Component Known Explain 4.60309
3 Parallel beta-helix repeat Domain Known Explain 4.50861
4 Pectin lyase fold Domain Known Explain 4.33184
5 Pectin lyase fold/virulence factor Domain Known Explain 3.90968
6 Autosomal Recessive Polycystic Kidney Disease Disease Known Explain 3.40191
7 negative regulation of cellular component movement Function Known Explain 3.33122
8 CAMLG gene Gene Known Explain 2.81366
9 Cell surface receptor IPT/TIG Domain Known Explain 2.67586
10 homeostatic process Function Known Explain 2.61992
11 TMEM2 gene Gene Inferred Explain 2.31767
12 cilium assembly Function Known Explain 1.70082
13 microtubule basal body Component Known Explain 1.30210
14 kidney development Function Known Explain 1.03883
15 Immunoglobulin E-set Domain Known Explain 0.87460
16 Cell-Cell Adhesion Function Known Explain 0.63282
17 Apical plasma membrane Component Known Explain 0.37973
18 AmbAllergen Domain Inferred Explain 0.36764
19 Pectate lyase/Amb allergen Domain Inferred Explain 0.30654
20 Carbohydrate-binding/sugar hydrolysis domain Domain Inferred Explain 0.26904
21 Arbutin Compound Known Explain 0.25579
22 Immunoglobulin-like fold Domain Known Explain 0.22394
23 Glycoside hydrolase, family 28 Domain Inferred Explain 0.20538
24 Pectinesterase, active site Domain Inferred Explain 0.19283
25 IPR022388 Domain Inferred Explain 0.14867
26 Pectinesterase, catalytic Domain Inferred Explain 0.13508
27 Protein of unknown function DUF1565 Domain Inferred Explain 0.12279
28 Disaggregatase related-2 Domain Inferred Explain 0.12279
29 IPR022442 Domain Inferred Explain 0.12279
30 Phage P22 tailspike Domain Inferred Explain 0.10978
31 Bacteriophage P22, tailspike Domain Inferred Explain 0.08461
32 Periplasmic copper-binding Domain Inferred Explain 0.07976
33 IPR022441 Domain Inferred Explain 0.07976
34 Pertactin virulence factor, N-terminal Domain Inferred Explain 0.07751
35 Pertactin virulence factor, C-terminal Domain Inferred Explain 0.07417
36 PKD3 gene Gene Inferred Explain 0.06764
37 Glycoside hydrolase, family 49 Domain Inferred Explain 0.06591
38 receptor activity Function Known Explain 0.06156
39 Pectate lyase, catalytic Domain Inferred Explain 0.06152
40 pirinixic acid Compound Known Explain 0.06084
41 IPR022444 Domain Inferred Explain 0.05613
42 Polycystic Kidney Diseases Disease Inferred Explain 0.05571
43 Polycystic Kidney - body part Other Inferred Explain 0.04838
44 Pertactin Domain Inferred Explain 0.04770
45 Cystic Kidney Diseases Disease Inferred Explain 0.03948
46 integral to membrane Component Known Explain 0.03452
47 Membrane Component Known Explain 0.03424
48 Polycystic Kidney, Autosomal Dominant Disease Inferred Explain 0.03287
49 Protein Binding Function Known Explain 0.03275
50 polygalacturonase activity Function Inferred Explain 0.02624
51 Peptidase S8A, subtilisin-related, campylobacter Domain Inferred Explain 0.02565
52 Outer membrane autotransporter barrel Domain Inferred Explain 0.02533
53 Autotransporter-associated beta strand repeat Domain Inferred Explain 0.02513
54 intrinsic to external side of plasma membrane Component Inferred Explain 0.02471
55 receptor recycling Function Inferred Explain 0.02219
56 Filamentous haemagglutinin, N-terminal, bacterial Domain Inferred Explain 0.02217
57 negative regulation of cilium movement Function Inferred Explain 0.02197
58 negative regulation of retinal ganglion cell axon guidance Function Inferred Explain 0.02150
59 Peptidase S6, IgA endopeptidase Domain Inferred Explain 0.02046
60 MAPK6 gene Gene Inferred Explain 0.01966
61 GPIHBP1 gene Gene Inferred Explain 0.01883
62 anchored to plasma membrane Component Inferred Explain 0.01633
63 regulation of cellular component movement Function Inferred Explain 0.01566
64 Autotransporter beta-domain Domain Inferred Explain 0.01523
65 pectinesterase activity Function Inferred Explain 0.01435
66 cell wall modification Function Inferred Explain 0.01415
67 B9D1 gene Gene Inferred Explain 0.01414
68 cell adhesion molecule binding Function Inferred Explain 0.01244
69 pectate lyase activity Function Inferred Explain 0.01233
70 MIRLET7B gene Gene Inferred Explain 0.01230
71 THY1 gene Gene Inferred Explain 0.01199
72 TNFRSF13B gene Gene Inferred Explain 0.01145
73 B9D2 gene Gene Inferred Explain 0.01084
74 MKS1 gene Gene Inferred Explain 0.01054
75 CBY1 gene Gene Inferred Explain 0.00938
76 CD59 gene Gene Inferred Explain 0.00893
77 TMEM67 gene Gene Inferred Explain 0.00887
78 BBS5 gene Gene Inferred Explain 0.00883
79 Transcription factor COE Domain Inferred Explain 0.00877
80 RAB3IP gene Gene Inferred Explain 0.00869
81 PPIB gene Gene Inferred Explain 0.00851
82 sensory cilium assembly Function Inferred Explain 0.00851
83 NF-kappa-B/Rel/dorsal Domain Inferred Explain 0.00846
84 Dorsal protein Domain Inferred Explain 0.00829
85 CA4 gene Gene Inferred Explain 0.00820
86 Rel homology Domain Inferred Explain 0.00804
87 NFAT5 gene Gene Inferred Explain 0.00795
88 Nuclear factor of activated T-cells 5 Domain Inferred Explain 0.00753
89 multicellular organismal homeostasis Function Inferred Explain 0.00748
90 KIF27 gene Gene Inferred Explain 0.00745
91 IPR020739 Domain Inferred Explain 0.00742
92 TTC8 gene Gene Inferred Explain 0.00733
93 IER3 gene Gene Inferred Explain 0.00722
94 Nuclear factor of activated T-cells 1 Domain Inferred Explain 0.00719
95 RPGRIP1L gene Gene Inferred Explain 0.00712
96 ARL6 gene Gene Inferred Explain 0.00704
97 anatomical structure homeostasis Function Inferred Explain 0.00701
98 PKD2 gene Gene Inferred Explain 0.00692
99 DNAI2 gene Gene Inferred Explain 0.00681
100 Nuclear factor of activated T cells (NFAT) Domain Inferred Explain 0.00676