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GCLM gene

Gene • C1415098

Definition

This gene is involved in the detoxification of endogenous reactive oxygen species. It also plays a role in drug and xenobiotic metabolism.

Synonyms

GCLM gene • gamma-glutamylcysteine synthetase • GLUTAMATE-CYSTEINE LIGASE, MODIFIER SUBUNIT • Glutamate-Cysteine Ligase, Modifier Subunit Gene • GCLM • GLCLR • GAMMA-GLUTAMYLCYSTEINE SYNTHETASE, REGULATORY SUBUNIT • GLUTAMATE-CYSTEINE LIGASE, REGULATORY

Linked items?Related concepts, ordered by their global importance in the network.

Protein Binding    Cyclosporine    7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide    Benzo(a)pyrene    Tetrachlorodibenzodioxin    Cytoplasmic matrix    Estradiol    arsenic trioxide    Fluorouracil    tert-Butylhydroperoxide    sodium arsenite    Doxorubicin    Quercetin    Arsenic    Curcumin    Cisplatin    Hydrogen Peroxide    Indomethacin    soluble fraction    Etoposide   

Related concepts

# Concept name Type Relation Support Score
1 glutamate-cysteine ligase catalytic subunit binding Function Known Explain 0.73845
2 Suprofen Compound Known Explain 0.65350
3 glutamate-cysteine ligase complex Component Known Explain 0.56570
4 glutamate-cysteine ligase activity Function Known Explain 0.52877
5 response to nitrosative stress Function Known Explain 0.52501
6 positive regulation of glutamate-cysteine ligase activity Function Known Explain 0.48665
7 S-sulindac Compound Known Explain 0.47645
8 regulation of mitochondrial depolarization Function Known Explain 0.47570
9 CBWD1 gene Gene Known Explain 0.38964
10 artesunate Compound Known Explain 0.36921
11 Ethacrynate Sodium Compound Known Explain 0.35442
12 Berylliosis Other Known Explain 0.29544
13 bis(4-hydroxycinnamoyl)methane Compound Known Explain 0.29522
14 demethoxycurcumin Compound Known Explain 0.29390
15 glutathione biosynthetic process Function Known Explain 0.29364
16 Thioctic Acid Compound Known Explain 0.28317
17 Ketoprofen Compound Known Explain 0.27611
18 darinaparsin Compound Known Explain 0.24359
19 regulation of blood vessel size Function Known Explain 0.23050
20 GCLC gene Gene Inferred Explain 0.22821
21 Synflex Compound Known Explain 0.18852
22 Cysteine Metabolism Pathway Function Known Explain 0.18115
23 4-phenylenediamine Compound Known Explain 0.17465
24 Chlorambucil Compound Known Explain 0.17414
25 Glutamate Metabolism Pathway Function Known Explain 0.14805
26 Staurosporine Compound Known Explain 0.14045
27 Diquat Compound Known Explain 0.12810
28 negative regulation of neuron apoptosis Function Known Explain 0.12037
29 triacsin C Compound Known Explain 0.11307
30 gedunin Compound Known Explain 0.10321
31 Glutathione Metabolism Pathway Function Known Explain 0.09875
32 tripterine Compound Known Explain 0.09661
33 Myocardial Infarction Disease Known Explain 0.09600
34 TNFRSF14 gene Gene Known Explain 0.08601
35 Vincristine Compound Known Explain 0.08483
36 anthra(1,9-cd)pyrazol-6(2H)-one Compound Known Explain 0.08358
37 Phenylpropionates Compound Inferred Explain 0.07573
38 Vitamin K 3 Compound Known Explain 0.07549
39 LY 294002 Compound Known Explain 0.07540
40 FTSJ1 gene Gene Known Explain 0.06723
41 MMA(III) Compound Known Explain 0.06657
42 Glutamate--cysteine ligase Domain Inferred Explain 0.06621
43 glycidamide Compound Known Explain 0.06502
44 PHLDA3 gene Gene Known Explain 0.06056
45 beta-Naphthoflavone Compound Known Explain 0.05883
46 Acetylcysteine Compound Known Explain 0.05562
47 Arachidonic Acid Compound Known Explain 0.05520
48 Cadmium Compound Known Explain 0.05264
49 response to oxidative stress Function Known Explain 0.05262
50 Ibuprofen Compound Known Explain 0.04967
51 Isoflavones Compound Known Explain 0.04959
52 Glutamate--cysteine ligase, monofunctional Domain Inferred Explain 0.04593
53 ARF6 gene Gene Known Explain 0.04156
54 Glutamate--cysteine ligase related Domain Inferred Explain 0.03961
55 Xenobiotic Metabolism Function Known Explain 0.03913
56 Glutamate--cysteine ligase, plant Domain Inferred Explain 0.03493
57 Glutamate--cysteine ligase, GCS2 Domain Inferred Explain 0.03466
58 protein heterodimerization activity Function Known Explain 0.03295
59 MCC gene Gene Known Explain 0.03278
60 Etoposide Compound Known Explain 0.02953
61 drug response Function Known Explain 0.02949
62 nickel sulfate Compound Known Explain 0.02912
63 Glutamate-cysteine ligase catalytic subunit Domain Inferred Explain 0.02827
64 Hydrogen Peroxide Compound Known Explain 0.02483
65 cellular response to nitrosative stress Function Inferred Explain 0.02479
66 soluble fraction Component Known Explain 0.02334
67 detoxification of nitrogen compound Function Inferred Explain 0.02276
68 Curcumin Compound Known Explain 0.02240
69 Indomethacin Compound Known Explain 0.02164
70 Cisplatin Compound Known Explain 0.02048
71 Quercetin Compound Known Explain 0.01954
72 Arsenic Compound Known Explain 0.01859
73 enzyme binding Function Inferred Explain 0.01728
74 regulation of glutamate-cysteine ligase activity Function Inferred Explain 0.01704
75 Doxorubicin Compound Known Explain 0.01605
76 positive regulation of ligase activity Function Inferred Explain 0.01584
77 sodium arsenite Compound Known Explain 0.01512
78 tert-Butylhydroperoxide Compound Known Explain 0.01152
79 Fluorouracil Compound Known Explain 0.01144
80 arsenic trioxide Compound Known Explain 0.01013
81 Estradiol Compound Known Explain 0.00970
82 regulation of membrane depolarization Function Inferred Explain 0.00911
83 Tetrachlorodibenzodioxin Compound Known Explain 0.00880
84 Cytoplasmic matrix Component Known Explain 0.00874
85 Benzo(a)pyrene Compound Known Explain 0.00829
86 NQO1 gene Gene Inferred Explain 0.00818
87 ABCC1 gene Gene Inferred Explain 0.00817
88 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide Compound Known Explain 0.00776
89 Protein Binding Function Known Explain 0.00768
90 Cyclosporine Compound Known Explain 0.00756
91 Neoplasm Invasiveness Disease Inferred Explain 0.00730
92 HMOX1 gene Gene Inferred Explain 0.00685
93 negative regulation of mitochondrial depolarization Function Inferred Explain 0.00655
94 HLA-DPB2 gene Gene Inferred Explain 0.00583
95 positive regulation of mitochondrial depolarization Function Inferred Explain 0.00576
96 DUSP6 gene Gene Inferred Explain 0.00564
97 Edema Disease Inferred Explain 0.00481
98 GSTZ1 gene Gene Inferred Explain 0.00467
99 BTNL2 gene Gene Inferred Explain 0.00407
100 PLAU gene Gene Inferred Explain 0.00345