CYP2A6 gene

Gene • C1413868

Definition

This gene plays a role in the oxidation of nicotine to its carcinogenic metabolites.

Synonyms

CYP2A6 gene • CYP2A6 • COUMARIN 7-HYDROXYLASE • CYP2A • cytochrome P450, family 2, subfamily A, polypeptide 6 • Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 Gene • P450PB • CPA6 • CYP2A3, FORMERLY • CYTOCHROME P450, PHENOBARBITAL-INDUCIBLE • CYTOCHROME P450, SUBFAMILY IIA, POLYPEPTIDE 6

Linked items?Related concepts, ordered by their global importance in the network.

Membrane    Metal Ion Binding    Calcium Valproate    Oxidation-Reduction    Tretinoin    Fluorouracil    Estradiol    Endoplasmic Reticulum    Water    Endoplasmic reticulum, membrane    7-ethyl-10-hydroxycamptothecin    Tamoxifen    Protons    Benzo(a)pyrene    Etoposide    Mifepristone    Microsomes    electron carrier activity    Oxygen    heme binding   

Related concepts

# Concept name Type Relation Support Score
1 Griseofulvin Compound Known Explain 0.28164
2 N-nitrosoguvacoline Compound Known Explain 0.27480
3 verbenone Compound Known Explain 0.27183
4 N-Nitrosopiperidine Compound Known Explain 0.27142
5 pyrazole Compound Known Explain 0.27142
6 Carcinoma, Large Cell Disease Known Explain 0.26654
7 Hempa Compound Known Explain 0.26272
8 losigame Compound Known Explain 0.26178
9 Methoxyflurane Compound Known Explain 0.21087
10 Opisthorchiasis Disease Known Explain 0.19333
11 2-propyl-4-pentenoic acid Compound Known Explain 0.18902
12 5-hydroxyvalproic acid Compound Known Explain 0.18902
13 4-hydroxyvalproic acid Compound Known Explain 0.18902
14 hydroxycotinine Compound Known Explain 0.17734
15 CYP2E1 gene Gene Inferred Explain 0.16860
16 N-Nitrosopyrrolidine Compound Known Explain 0.16733
17 CYP2B6 gene Gene Inferred Explain 0.15984
18 N-ethyl-3-toluamide Compound Known Explain 0.14519
19 CYP2C19 gene Gene Inferred Explain 0.14075
20 coumarin 7-hydroxylase activity Function Known Explain 0.13975
21 N-nitrosomorpholine Compound Known Explain 0.13757
22 CYP2C9 gene Gene Inferred Explain 0.13545
23 CYP2A13 gene Gene Inferred Explain 0.12941
24 coumarin catabolic process Function Known Explain 0.12609
25 Transamine Compound Known Explain 0.12283
26 N-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide Compound Known Explain 0.12023
27 CYP1A2 gene Gene Inferred Explain 0.11828
28 CYP2D6 gene Gene Inferred Explain 0.11805
29 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime Compound Known Explain 0.11790
30 COUMARIN RESISTANCE Disease Known Explain 0.11256
31 Liver Diseases, Parasitic Disease Known Explain 0.10730
32 CYP3A4 gene Gene Inferred Explain 0.10685
33 Nicotine Dependence Disease Known Explain 0.10483
34 CYP2C8 gene Gene Inferred Explain 0.10415
35 Carcinogens Compound Known Explain 0.10407
36 Proadifen Compound Known Explain 0.10401
37 N-nitroso(di-n-propyl)amine Compound Known Explain 0.10116
38 CYP3A5 gene Gene Inferred Explain 0.09549
39 CYP2A7 gene Gene Inferred Explain 0.09369
40 CYP4X1 gene Gene Inferred Explain 0.09221
41 CYP2J2 gene Gene Inferred Explain 0.09128
42 CYP2C18 gene Gene Inferred Explain 0.09097
43 CYP3A43 gene Gene Inferred Explain 0.09088
44 CYP4Z1 gene Gene Inferred Explain 0.09066
45 Nitrosamines Compound Known Explain 0.09011
46 tryptamine Known Explain 0.08994
47 CYP2F1 gene Gene Inferred Explain 0.08991
48 CYP2S1 gene Gene Inferred Explain 0.08942
49 CYP4B1 gene Gene Inferred Explain 0.08903
50 7-hydroxycoumarin Compound Known Explain 0.08894
51 Muscarinic Agonists Compound Known Explain 0.08636
52 Safrole Compound Known Explain 0.08545
53 Cotinine Compound Known Explain 0.08508
54 PLD118 Compound Known Explain 0.08427
55 Estazolam Compound Known Explain 0.08342
56 CYP3A7 gene Gene Inferred Explain 0.08267
57 1,2,4-trihydroxy-9,10-anthracenedione Compound Known Explain 0.08267
58 carminic acid Compound Known Explain 0.08267
59 Oat cell carcinoma Disease Known Explain 0.08085
60 epsilon-viniferin Compound Known Explain 0.08020
61 CGS-16949A Compound Known Explain 0.07918
62 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane Compound Known Explain 0.07899
63 Isopilocarpine Compound Known Explain 0.07885
64 5-(4-(3-(4-cyclohexyl-2-propylphenoxy)propoxy)phenyl)-1,3-oxazolidine-2,4-dione Compound Known Explain 0.07866
65 Fluphenazine Compound Known Explain 0.07863
66 CYP1B1 gene Gene Inferred Explain 0.07577
67 CYP1A1 gene Gene Inferred Explain 0.07478
68 1,7-dimethylxanthine Compound Known Explain 0.07330
69 2-anisidine Compound Known Explain 0.07296
70 Celsior Compound Known Explain 0.07229
71 norharman Compound Known Explain 0.07180
72 Amitrole Compound Known Explain 0.07176
73 coumarin metabolic process Function Known Explain 0.07167
74 exogenous drug catabolic process Function Known Explain 0.07167
75 Teniposide Compound Known Explain 0.07147
76 Deet Compound Known Explain 0.06880
77 Halothane Compound Known Explain 0.06776
78 trans-1,2-dihydro-1,2-naphthalenediol Compound Known Explain 0.06773
79 Methoxsalen Compound Known Explain 0.06442
80 1-(4-(4-(4-((4-(2,4-difluorophenyl)-4-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-2-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-3-(1-methylethyl)-2-imidazolidinone Compound Known Explain 0.06397
81 Nicardipine Compound Known Explain 0.06291
82 Caffeine metabolism - Homo sapiens (human) Pathway Known Explain 0.06179
83 coumarin Compound Known Explain 0.06161
84 olivacine Compound Known Explain 0.06100
85 Nasopharyngeal Neoplasms Disease Known Explain 0.06079
86 Hepatitis B Disease Known Explain 0.05948
87 CYP19A1 gene Gene Inferred Explain 0.05841
88 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole Compound Known Explain 0.05671
89 Diethylnitrosamine Compound Known Explain 0.05470
90 alizarin Compound Known Explain 0.05319
91 Hepatitis C Disease Known Explain 0.05274
92 1-phenylazo-2-naphthol Compound Known Explain 0.05195
93 bromodichloromethane Compound Known Explain 0.05172
94 2,4,5,2',5'-pentachlorobiphenyl Compound Known Explain 0.05137
95 TOBACCO ADDICTION, SUSCEPTIBILITY TO Disease Known Explain 0.05113
96 Ditiocarb Compound Known Explain 0.04944
97 9(10)-EpOME Compound Known Explain 0.04935
98 alpha-Hydroxy-N-desmethyltamoxifen Compound Known Explain 0.04935
99 19-Oxoandrost-4-ene-3,17-dione Compound Known Explain 0.04935
100 19-Oxotestosterone Compound Known Explain 0.04935