EGLN1 gene

Gene • C1412925

Synonyms

EGLN1 gene • egl nine homolog 1 (C. elegans) • ZMYND6 • SM-20 • HPH2 • PHD2 • CHROMOSOME 1 OPEN READING FRAME 12 • EGL9, C. ELEGANS, HOMOLOG OF, 1 • EGLN1 • HIF-PROLYL HYDROXYLASE 2 • HIF prolyl hydroxylase 2 • SM20, RAT, HOMOLOG OF • HIFPH2 • ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 6 • PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2 • C1ORF12 • SM20

Linked items?Related concepts, ordered by their global importance in the network.

Protein Binding    Metal Ion Binding    7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide    Tetrachlorodibenzodioxin    zinc ion binding    Cytoplasmic matrix    Oxidation-Reduction    Calcitriol    Pathways in cancer - Homo sapiens (human)    Zinc    VHL gene    HIF1A gene    Oxygen    iron ion binding    POLR2A gene    Iron    response to hypoxia    Zinc Sulfate    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen    HIST1H3A gene   

Related concepts

# Concept name Type Relation Support Score
1 peptidyl-proline dioxygenase activity Function Known Explain 2.19856
2 ERYTHROCYTOSIS, FAMILIAL, 3 Disease Known Explain 1.97916
3 oxygen homeostasis Function Known Explain 1.51740
4 ferrous sulfate Compound Known Explain 1.26130
5 Prolyl 4-hydroxylase, alpha subunit Domain Known Explain 1.09585
6 Oxoglutarate/iron-dependent oxygenase Domain Known Explain 1.03000
7 HIF3A gene Gene Known Explain 0.89379
8 Zinc finger, MYND-type Domain Known Explain 0.83092
9 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine Compound Known Explain 0.75523
10 L-ascorbic acid binding Function Known Explain 0.69032
11 alpha-naphthoflavone Compound Known Explain 0.63209
12 ING4 gene Gene Known Explain 0.48360
13 OS9 gene Gene Known Explain 0.46088
14 negative regulation of transcription factor activity Function Known Explain 0.44100
15 zinc chloride Compound Known Explain 0.40748
16 EPAS1 gene Gene Known Explain 0.39838
17 cobaltous chloride Compound Known Explain 0.36229
18 Renal cell carcinoma - Homo sapiens (human) Pathway Known Explain 0.34800
19 peptidyl-proline 3-dioxygenase activity Function Inferred Explain 0.31880
20 nickel chloride Compound Known Explain 0.27094
21 HIST1H3A gene Gene Known Explain 0.25525
22 procollagen-proline dioxygenase activity Function Inferred Explain 0.25433
23 OSR1 gene Gene Known Explain 0.25031
24 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Function Known Explain 0.22263
25 HIF1A gene Gene Known Explain 0.19850
26 response to hypoxia Function Known Explain 0.17721
27 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Function Known Explain 0.17083
28 Zinc Sulfate Compound Known Explain 0.16396
29 POLR2A gene Gene Known Explain 0.14422
30 Erythrocytosis Disease Inferred Explain 0.13513
31 procollagen-proline 3-dioxygenase activity Function Inferred Explain 0.11970
32 Oxygen Compound Known Explain 0.11185
33 iron ion binding Function Known Explain 0.10912
34 VHL gene Gene Known Explain 0.10243
35 Iron Compound Known Explain 0.10205
36 Zinc Compound Known Explain 0.08930
37 Pathways in cancer - Homo sapiens (human) Pathway Known Explain 0.08547
38 gas homeostasis Function Inferred Explain 0.08476
39 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Function Inferred Explain 0.07937
40 NARFL gene Gene Inferred Explain 0.04684
41 EGLN3 gene Gene Inferred Explain 0.04112
42 Calcitriol Compound Known Explain 0.03247
43 Eight-Twenty-One Domain Inferred Explain 0.03000
44 EGLN2 gene Gene Inferred Explain 0.02815
45 Oxidation-Reduction Function Known Explain 0.02648
46 P4HA3 gene Gene Inferred Explain 0.02067
47 Metal Ion Binding Function Known Explain 0.02056
48 P4HTM gene Gene Inferred Explain 0.01901
49 zinc ion binding Function Known Explain 0.01865
50 Cytoplasmic matrix Component Known Explain 0.01858
51 ALAS2 gene Gene Inferred Explain 0.01834
52 Tetrachlorodibenzodioxin Compound Known Explain 0.01785
53 LEPREL2 gene Gene Inferred Explain 0.01756
54 P4HA2 gene Gene Inferred Explain 0.01740
55 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide Compound Known Explain 0.01672
56 P4HA1 gene Gene Inferred Explain 0.01637
57 LEPREL1 gene Gene Inferred Explain 0.01487
58 Protein Binding Function Known Explain 0.01457
59 nitric oxide homeostasis Function Inferred Explain 0.01445
60 Myeloid transforming gene on chromosome 8 (MTG8) Domain Inferred Explain 0.01269
61 Nervy Domain Inferred Explain 0.01269
62 NHR2-like Domain Inferred Explain 0.01248
63 LEPRE1 gene Gene Inferred Explain 0.01153
64 Myeloid transforming gene related protein-1 (MTGR1) Domain Inferred Explain 0.01130
65 PLOD2 gene Gene Inferred Explain 0.01058
66 PLOD3 gene Gene Inferred Explain 0.01050
67 PLOD1 gene Gene Inferred Explain 0.01047
68 WNT7B gene Gene Inferred Explain 0.01003
69 Myeloid transforming gene on chromosome 16 (MTG16) Domain Inferred Explain 0.00905
70 ERYTHROCYTOSIS, FAMILIAL, 2 Disease Inferred Explain 0.00861
71 Polycythemia, primary familial and congenital Disease Inferred Explain 0.00818
72 SOD2 gene Gene Inferred Explain 0.00812
73 TAFH/NHR1 Domain Inferred Explain 0.00671
74 HIF1AN gene Gene Inferred Explain 0.00589
75 chemical homeostasis Function Inferred Explain 0.00579
76 MT1E gene Gene Inferred Explain 0.00569
77 Isopenicillin N synthase Domain Inferred Explain 0.00546
78 Prolyl 4-hydroxylase alpha-subunit, N-terminal Domain Inferred Explain 0.00523
79 Isopenicillin N synthase, conserved site Domain Inferred Explain 0.00511
80 MT1X gene Gene Inferred Explain 0.00493
81 DNAJB1 gene Gene Inferred Explain 0.00464
82 HMOX1 gene Gene Inferred Explain 0.00456
83 Procollagen-lysine 5-dioxygenase Domain Inferred Explain 0.00420
84 Cell Nucleus Component Inferred Explain 0.00393
85 Alkylated DNA repair protein AlkB Domain Inferred Explain 0.00381
86 TRPV1 gene Gene Inferred Explain 0.00372
87 VEGFA gene Gene Inferred Explain 0.00355
88 OGFOD1 gene Gene Inferred Explain 0.00334
89 SMYD4 gene Gene Inferred Explain 0.00330
90 monooxygenase activity Function Inferred Explain 0.00318
91 IPR021537 Domain Inferred Explain 0.00311
92 TNF gene Gene Inferred Explain 0.00308
93 SLC30A7 gene Gene Inferred Explain 0.00293
94 MT2A gene Gene Inferred Explain 0.00291
95 ARNT gene Gene Inferred Explain 0.00290
96 Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain Domain Inferred Explain 0.00286
97 C17orf101 gene Gene Inferred Explain 0.00280
98 Cyclosporine Compound Inferred Explain 0.00280
99 OGFOD2 gene Gene Inferred Explain 0.00273
100 MTF1 gene Gene Inferred Explain 0.00270