ALAS2 gene

Gene • C1412331

Synonyms

ALAS2 gene • ALAS, ERYTHROID • 5-@AMINOLEVULINATE SYNTHASE, ERYTHROID-SPECIFIC • ALASE • DELTA-AMINOLEVULINATE SYNTHASE 2 • aminolevulinate, delta-, synthase 2 • ALAS2 • sideroblastic/hypochromic anemia

Linked items?Related concepts, ordered by their global importance in the network.

Protein Binding    arsenic trioxide    Mitochondria    GRB2 gene    7-ethyl-10-hydroxycamptothecin    TGFB1 gene    Inner mitochondrial membrane    Mitochondrial matrix    acyltransferase activity    response to hypoxia    Coenzyme A    Anabolism    pyridoxal phosphate binding    Carbon Dioxide    cellular iron ion homeostasis    Acetyl Coenzyme A    Glycine, Serine and Threonine Metabolism Pathway    Porphyrin and Chlorophyll Metabolism Pathway    coenzyme binding    SUCLA2 gene   

Related concepts

# Concept name Type Relation Support Score
1 2-Amino-3-oxoadipate Compound Known Explain 3.30423
2 L-2-Amino-3-oxobutanoic acid Compound Known Explain 2.91811
3 5-aminolevulinate synthase activity Function Known Explain 2.19395
4 hemoglobin biosynthetic process Function Known Explain 2.02143
5 oxygen homeostasis Function Known Explain 1.84625
6 Aminolevulinic Acid Compound Known Explain 1.71043
7 succinyl-coenzyme A Compound Known Explain 1.56956
8 ALAS1 gene Gene Inferred Explain 1.48765
9 Sideroblastic anemia Disease Known Explain 1.37333
10 transferase activity, transferring nitrogenous groups Function Known Explain 1.36111
11 glycine binding Function Known Explain 1.29541
12 RABGGTB gene Gene Known Explain 1.01862
13 erythrocyte differentiation Function Known Explain 0.91445
14 porphyrin metabolic process Function Known Explain 0.87040
15 Glycine Compound Known Explain 0.85287
16 SUCLA2 gene Gene Known Explain 0.80712
17 tetrapyrrole biosynthetic process Function Known Explain 0.77699
18 Porphyrin and Chlorophyll Metabolism Pathway Function Known Explain 0.68453
19 heme biosynthetic process Function Known Explain 0.66933
20 Glycine, Serine and Threonine Metabolism Pathway Function Known Explain 0.60318
21 Acetyl Coenzyme A Compound Known Explain 0.54946
22 coenzyme binding Function Known Explain 0.51337
23 cellular iron ion homeostasis Function Known Explain 0.33293
24 Coenzyme A Compound Known Explain 0.31949
25 Carbon Dioxide Compound Known Explain 0.31621
26 pyridoxal phosphate binding Function Known Explain 0.27707
27 response to hypoxia Function Known Explain 0.21718
28 Anabolism Function Known Explain 0.20429
29 Mitochondrial matrix Component Known Explain 0.18668
30 acyltransferase activity Function Known Explain 0.14959
31 GCAT gene Gene Inferred Explain 0.11331
32 Inner mitochondrial membrane Component Known Explain 0.10400
33 5-aminolevulinate synthase presequence Domain Inferred Explain 0.08995
34 TGFB1 gene Gene Known Explain 0.08386
35 hemoglobin metabolic process Function Inferred Explain 0.07243
36 Levulinic Acids Compound Inferred Explain 0.06665
37 7-ethyl-10-hydroxycamptothecin Compound Known Explain 0.06520
38 Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase Domain Inferred Explain 0.05697
39 FECH gene Gene Inferred Explain 0.05297
40 CPOX gene Gene Inferred Explain 0.04792
41 cellular macromolecule biosynthetic process Function Inferred Explain 0.04787
42 GRB2 gene Gene Known Explain 0.04404
43 Mitochondria Component Known Explain 0.04271
44 ALAD gene Gene Inferred Explain 0.04227
45 N-succinyltransferase activity Function Inferred Explain 0.03994
46 SLC25A38 gene Gene Inferred Explain 0.03957
47 INHA gene Gene Inferred Explain 0.02985
48 arsenic trioxide Compound Known Explain 0.02961
49 Porphyrias Disease Inferred Explain 0.02734
50 Tetrapyrrole biosynthesis, hydroxymethylbilane synthase Domain Inferred Explain 0.02495
51 EPO gene Gene Inferred Explain 0.02369
52 MITOCHONDRIAL MYOPATHY AND SIDEROBLASTIC ANEMIA Disease Inferred Explain 0.02350
53 Keto Acids Compound Inferred Explain 0.02196
54 manganese chloride Compound Inferred Explain 0.02170
55 gas homeostasis Function Inferred Explain 0.02113
56 INHBA gene Gene Inferred Explain 0.01958
57 Amino Acids Compound Inferred Explain 0.01956
58 Glycine receptor alpha Domain Inferred Explain 0.01906
59 tetrapyrrole metabolic process Function Inferred Explain 0.01634
60 IPR022419 Domain Inferred Explain 0.01569
61 Protein Binding Function Known Explain 0.01517
62 SUCLG2 gene Gene Inferred Explain 0.01507
63 DLD gene Gene Inferred Explain 0.01457
64 IPR022418 Domain Inferred Explain 0.01439
65 ABCB7 gene Gene Inferred Explain 0.01423
66 porphyrin biosynthetic process Function Inferred Explain 0.01391
67 SUCLG1 gene Gene Inferred Explain 0.01385
68 Superoxides Compound Inferred Explain 0.01276
69 UROD gene Gene Inferred Explain 0.01259
70 OXCT2 gene Gene Inferred Explain 0.01243
71 UROS gene Gene Inferred Explain 0.01236
72 GLRA4 gene Gene Inferred Explain 0.01219
73 OGDHL gene Gene Inferred Explain 0.01218
74 heme metabolic process Function Inferred Explain 0.01197
75 NARFL gene Gene Inferred Explain 0.01155
76 Aminotransferase, class I/II Domain Inferred Explain 0.01094
77 OGDH gene Gene Inferred Explain 0.01087
78 GNMT gene Gene Inferred Explain 0.01062
79 ACAA2 gene Gene Inferred Explain 0.01033
80 IPR022417 Domain Inferred Explain 0.01031
81 protoporphyrinogen IX metabolic process Function Inferred Explain 0.01007
82 PPOX gene Gene Inferred Explain 0.00996
83 ACCSL gene Gene Inferred Explain 0.00992
84 ACCS gene Gene Inferred Explain 0.00984
85 ACAA1 gene Gene Inferred Explain 0.00971
86 GLRA3 gene Gene Inferred Explain 0.00969
87 SOD2 gene Gene Inferred Explain 0.00965
88 GLRA2 gene Gene Inferred Explain 0.00933
89 Manganese Compound Inferred Explain 0.00929
90 HADHB gene Gene Inferred Explain 0.00901
91 HMBS gene Gene Inferred Explain 0.00893
92 Anemia Disease Inferred Explain 0.00891
93 DLST gene Gene Inferred Explain 0.00883
94 porphyrin catabolic process Function Inferred Explain 0.00882
95 uroporphyrinogen III metabolic process Function Inferred Explain 0.00867
96 chlorophyll metabolic process Function Inferred Explain 0.00852
97 Dysmyelopoietic Syndromes Disease Inferred Explain 0.00846
98 amidinotransferase activity Function Inferred Explain 0.00837
99 OXCT1 gene Gene Inferred Explain 0.00806
100 MUT gene Gene Inferred Explain 0.00799