AKR1C1 gene

Gene • C1412324

Synonyms

AKR1C1 gene • AKR1C1 • aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) • MBAB • DD1 • DDH • HAKRC • ALDO-KETO REDUCTASE C • ALDO-KETO REDUCTASE FAMILY 1, MEMBER 1 • DDH1 • DIHYDRODIOL DEHYDROGENASE, TYPE I

Linked items?Related concepts, ordered by their global importance in the network.

Cytoplasm    Cytoplasmic matrix    Oxidation-Reduction    Fluorouracil    tert-Butylhydroperoxide    Progesterone    sodium arsenite    oxidoreductase activity    MAPK3 gene    testosterone enanthate    Hydrogen Peroxide    Indomethacin    Protons    Benzo(a)pyrene    sulindac sulfide    Fenretinide    Nicotinamide adenine dinucleotide (NAD)    NADH    NADP    2,3-dimethoxy-1,4-naphthoquinone   

Related concepts

# Concept name Type Relation Support Score
1 quinomethionate Compound Known Explain 4.04194
2 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity Function Known Explain 2.99191
3 20-alpha-hydroxysteroid dehydrogenase activity Function Known Explain 2.93475
4 N-(4-chlorobenzoyl)melatonin Compound Known Explain 2.92734
5 indanol dehydrogenase activity Function Known Explain 2.81980
6 7-hydroxyflavone Compound Known Explain 2.11806
7 benzo(a)pyrene-7,8-dione Compound Known Explain 2.03712
8 trans-1,2-Dihydrobenzene-1,2-diol Compound Known Explain 1.88033
9 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Function Known Explain 1.83976
10 9,10-phenanthrenequinone Compound Known Explain 1.79302
11 response to organophosphorus Function Known Explain 1.72623
12 5alpha-Androstane-3,17-dione Compound Known Explain 1.53292
13 Catechol Compound Known Explain 1.34822
14 bile acid binding Function Known Explain 1.11391
15 bile acid and bile salt transport Function Known Explain 1.11343
16 methylparaoxon Compound Known Explain 0.85212
17 cholesterol absorption Function Known Explain 0.84429
18 aldo-keto reductase activity Function Known Explain 0.74777
19 carboxylic acid binding Function Known Explain 0.68432
20 Dibutyl Phthalate Compound Known Explain 0.63556
21 Ethacrynate Sodium Compound Known Explain 0.58835
22 bile acid metabolism Function Known Explain 0.56247
23 GG 745 Compound Known Explain 0.53550
24 2-tert-butylhydroquinone Compound Known Explain 0.51629
25 AKR1C3 gene Gene Inferred Explain 0.45859
26 Methyl Parathion Compound Known Explain 0.45536
27 AKR1C2 gene Gene Inferred Explain 0.39524
28 Cell Transformation, Neoplastic Disease Known Explain 0.37409
29 Androsterone Compound Known Explain 0.36729
30 naringenin Compound Known Explain 0.34837
31 20-Methylcholanthrene Compound Known Explain 0.34346
32 Malathion Compound Known Explain 0.33695
33 Naphthalene-1,2-diol Compound Known Explain 0.33658
34 1,2-Dihydronaphthalene-1,2-diol Compound Known Explain 0.32586
35 Endometrial Neoplasms Disease Known Explain 0.28935
36 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Function Inferred Explain 0.26699
37 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone Compound Known Explain 0.20685
38 AKR1C4 gene Gene Inferred Explain 0.20192
39 Cholesterol Homeostasis Function Known Explain 0.19095
40 Cytomel Compound Known Explain 0.18858
41 Xenobiotic Metabolism Function Known Explain 0.17929
42 C21-Steroid Hormone Metabolism Pathway Function Known Explain 0.15994
43 Digestion Function Known Explain 0.15049
44 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) Pathway Known Explain 0.14505
45 LGD 1069 Compound Known Explain 0.13248
46 protein homooligomerization Function Known Explain 0.13185
47 sodium arsenate Compound Known Explain 0.12709
48 gedunin Compound Known Explain 0.12320
49 DHDH gene Gene Inferred Explain 0.11748
50 Reactive Oxygen Species Compound Known Explain 0.11425
51 tripterine Compound Known Explain 0.11312
52 4-phenylbutyric acid Compound Known Explain 0.09913
53 glycidamide Compound Known Explain 0.09555
54 NADP Compound Known Explain 0.07989
55 NADH Compound Known Explain 0.07246
56 2,3-dimethoxy-1,4-naphthoquinone Compound Known Explain 0.06732
57 Nicotinamide adenine dinucleotide (NAD) Compound Known Explain 0.06320
58 response to insecticide Function Inferred Explain 0.04433
59 Protons Compound Known Explain 0.04309
60 sulindac sulfide Compound Known Explain 0.04158
61 Fenretinide Compound Known Explain 0.04144
62 monocarboxylic acid binding Function Inferred Explain 0.03769
63 Benzo(a)pyrene Compound Known Explain 0.03502
64 Indomethacin Compound Known Explain 0.02930
65 Hydrogen Peroxide Compound Known Explain 0.02709
66 oxidoreductase activity Function Known Explain 0.02652
67 MAPK3 gene Gene Known Explain 0.02298
68 HSD17B2 gene Gene Inferred Explain 0.02271
69 testosterone enanthate Compound Known Explain 0.02261
70 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Function Inferred Explain 0.01956
71 3-alpha-hydroxysteroid dehydrogenase (A-specific) activity Function Inferred Explain 0.01886
72 AKR7A2 gene Gene Inferred Explain 0.01851
73 Oxidation-Reduction Function Known Explain 0.01692
74 canalicular bile acid transport Function Inferred Explain 0.01640
75 AKR1A1 gene Gene Inferred Explain 0.01632
76 sodium arsenite Compound Known Explain 0.01599
77 Progesterone Compound Known Explain 0.01584
78 CYP2A13 gene Gene Inferred Explain 0.01542
79 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Function Inferred Explain 0.01349
80 CYP1A1 gene Gene Inferred Explain 0.01278
81 alcohol dehydrogenase (NADP+) activity Function Inferred Explain 0.01274
82 aldehyde reductase activity Function Inferred Explain 0.01272
83 Fluorouracil Compound Known Explain 0.01206
84 tert-Butylhydroperoxide Compound Known Explain 0.01118
85 gibberellin binding activity Function Inferred Explain 0.01020
86 SRD5A1 gene Gene Inferred Explain 0.01018
87 AKR1B1 gene Gene Inferred Explain 0.00990
88 Cytoplasmic matrix Component Known Explain 0.00980
89 testosterone 17-beta-dehydrogenase (NADP+) activity Function Inferred Explain 0.00895
90 SRD5A2 gene Gene Inferred Explain 0.00890
91 AKR1D1 gene Gene Inferred Explain 0.00859
92 TRIM16 gene Gene Inferred Explain 0.00841
93 lipoic acid binding Function Inferred Explain 0.00820
94 testosterone 17-beta-dehydrogenase activity Function Inferred Explain 0.00819
95 SLC2A1 gene Gene Inferred Explain 0.00774
96 penicillin binding Function Inferred Explain 0.00742
97 RFC3 gene Gene Inferred Explain 0.00733
98 CYP1B1 gene Gene Inferred Explain 0.00710
99 ATP8B1 gene Gene Inferred Explain 0.00694
100 AKR7A3 gene Gene Inferred Explain 0.00659