TPO gene

Gene • C1364508

Definition

This gene is involved in thyroid hormone biosynthesis.

Synonyms

TPO gene • THYROID PEROXIDASE • TPO • THYROPEROXIDASE • TPX • Thyroid Peroxidase Gene

Linked items?Related concepts, ordered by their global importance in the network.

Cell membrane    Oxidation-Reduction    Mitochondria    Tretinoin    integral to plasma membrane    Water    calcium ion binding    oxidoreductase activity    Amiodarone    Hydrogen Peroxide    Protons    Cytokine-cytokine receptor interaction - Homo sapiens (human)    Cell surface    heme binding    Jak-STAT signaling pathway - Homo sapiens (human)    Azacitidine    response to oxidative stress    Hematopoietic cell lineage - Homo sapiens (human)    IPR012351    Four-helical cytokine-like, core   

Related concepts

# Concept name Type Relation Support Score
1 iodide peroxidase activity Function Known Explain 10.66778
2 Deficiency of iodide peroxidase Disease Known Explain 10.32674
3 2-Aminoacrylate Compound Known Explain 10.17429
4 Triiodothyronine Compound Known Explain 5.65549
5 O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine Compound Known Explain 5.46376
6 Iodide Compound Known Explain 5.46376
7 Thrombopoeitin Domain Known Explain 4.36462
8 Org 41841 Known Explain 4.12122
9 Erythropoietin/thrombopoeitin, conserved site Domain Known Explain 3.81298
10 Erythropoietin/thrombopoeitin Domain Known Explain 3.81298
11 Cretinism Disease Known Explain 3.64709
12 Ethylenethiourea Compound Known Explain 2.72809
13 Methimazole Compound Known Explain 2.42186
14 Goiter Disease Known Explain 2.37570
15 Iodine Compound Known Explain 2.09216
16 Sodium Iodide Compound Known Explain 2.08521
17 TXNDC11 gene Gene Known Explain 1.95241
18 peroxidase activity Function Known Explain 1.43178
19 Tyrosine Compound Known Explain 1.33555
20 hormone biosynthetic process Function Known Explain 1.17108
21 hydrogen peroxide catabolic process Function Known Explain 1.13742
22 DUOX1 gene Gene Known Explain 0.82724
23 IPR012351 Known Explain 0.69104
24 Four-helical cytokine-like, core Domain Known Explain 0.60646
25 Hypothyroidism Disease Inferred Explain 0.44192
26 DIO1 gene Gene Inferred Explain 0.41565
27 Tyrosine Metabolism Pathway Function Known Explain 0.38838
28 Autoimmune thyroid disease - Homo sapiens (human) Pathway Known Explain 0.38153
29 Hematopoietic cell lineage - Homo sapiens (human) Pathway Known Explain 0.23641
30 Thyronines Compound Inferred Explain 0.21889
31 response to oxidative stress Function Known Explain 0.21420
32 Erythropoietin Domain Inferred Explain 0.20390
33 DIO3 gene Gene Inferred Explain 0.19602
34 DIO2 gene Gene Inferred Explain 0.18724
35 Jak-STAT signaling pathway - Homo sapiens (human) Pathway Known Explain 0.13913
36 heme binding Function Known Explain 0.13543
37 Azacitidine Compound Known Explain 0.12861
38 SDS gene Gene Inferred Explain 0.12520
39 Cell surface Component Known Explain 0.09580
40 Cytokine-cytokine receptor interaction - Homo sapiens (human) Pathway Known Explain 0.08937
41 Lingual Goiter Disease Inferred Explain 0.08632
42 DUOX2 gene Gene Inferred Explain 0.08605
43 Bird-headed dwarfism with progressive ataxia, insulin-resistant diabetes, goiter, and primary gonadal insufficiency Other Inferred Explain 0.08242
44 Protons Compound Known Explain 0.08241
45 Imidazolidines Compound Inferred Explain 0.07987
46 GOITER, MULTINODULAR, CYSTIC RENAL DISEASE AND DIGITAL ANOMALIES Disease Inferred Explain 0.06636
47 Hydrogen Peroxide Compound Known Explain 0.06034
48 oxidoreductase activity Function Known Explain 0.05323
49 Bone Diseases, Endocrine Disease Inferred Explain 0.04906
50 Amiodarone Compound Known Explain 0.04808
51 TSHR gene Gene Inferred Explain 0.04692
52 Pendred's syndrome Disease Inferred Explain 0.04195
53 Oxidation-Reduction Function Known Explain 0.03914
54 calcium ion binding Function Known Explain 0.03844
55 Halogens Compound Inferred Explain 0.03423
56 TSHB gene Gene Inferred Explain 0.03329
57 Water Compound Known Explain 0.03191
58 Hyperthyroidism Disease Inferred Explain 0.03182
59 Thyroid Diseases Disease Inferred Explain 0.03125
60 Diiodotyrosine Compound Inferred Explain 0.03123
61 Monoiodotyrosine Compound Inferred Explain 0.03123
62 EPO gene Gene Inferred Explain 0.02972
63 Iodides Compound Inferred Explain 0.02792
64 Thiourea Compound Inferred Explain 0.02580
65 FMO2 gene Gene Inferred Explain 0.02574
66 integral to plasma membrane Component Known Explain 0.02571
67 Tretinoin Compound Known Explain 0.02484
68 Thyroid Hormones Compound Inferred Explain 0.02420
69 Phosphotyrosine Compound Inferred Explain 0.02340
70 Mitochondria Component Known Explain 0.02319
71 Haem peroxidase Domain Inferred Explain 0.02235
72 Graves' Disease Disease Inferred Explain 0.02052
73 Haem peroxidase, animal Domain Inferred Explain 0.01984
74 perchlorate Compound Inferred Explain 0.01951
75 Haem peroxidase, animal, subgroup Domain Inferred Explain 0.01924
76 Dwarfism Other Inferred Explain 0.01798
77 Lingual Thyroid Other Inferred Explain 0.01662
78 SLC5A5 gene Gene Inferred Explain 0.01589
79 TG gene Gene Inferred Explain 0.01549
80 Haem peroxidase, plant/fungal/bacterial Domain Inferred Explain 0.01393
81 Cell membrane Component Known Explain 0.01381
82 Imidazoles Compound Inferred Explain 0.01352
83 tryparedoxin peroxidase activity Function Inferred Explain 0.01316
84 Reverse Triiodothyronine Compound Inferred Explain 0.01280
85 FSHR gene Gene Inferred Explain 0.01270
86 Insulin resistant diabetes Disease Inferred Explain 0.01264
87 Diiodothyronines Compound Inferred Explain 0.01260
88 Bromoperoxidase/chloroperoxidase, C-terminal Domain Inferred Explain 0.01249
89 Alkylhydroperoxidase AhpD Domain Inferred Explain 0.01246
90 brassinosteroid biosynthetic process Function Inferred Explain 0.01234
91 Sodium Compounds Compound Inferred Explain 0.01234
92 Catalase-peroxidase haem Domain Inferred Explain 0.01205
93 Plant ascorbate peroxidase Domain Inferred Explain 0.01162
94 Fungal lignin peroxidase Domain Inferred Explain 0.01162
95 Plant peroxidase Domain Inferred Explain 0.01162
96 LHCGR gene Gene Inferred Explain 0.01159
97 hormone activity Function Inferred Explain 0.01155
98 Sulfhydryl Compounds Compound Inferred Explain 0.01139
99 ascorbate glutathione cycle Function Inferred Explain 0.01137
100 PXDNL gene Gene Inferred Explain 0.01132