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CYP1A2 gene
Gene • C1332826
Definition
This gene plays a role in the oxidation/activation of procarcinogens. It is also involved in the metabolism of drugs and other xenobiotics.
Synonyms
CYP1A2 gene • CYP1A2 • cytochrome P450, family 1, subfamily A, polypeptide 2 • CYTOCHROME P-450, AROMATIC COMPOUND-INDUCIBLE • DIOXIN-INDUCIBLE P3-450 • P3-450 • CP12 • Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 Gene • CYTOCHROME P450, SUBFAMILY I, POLYPEPTIDE 2
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Membrane
Metal Ion Binding
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Benzo(a)pyrene
Tetrachlorodibenzodioxin
Estradiol
Aflatoxin B1
pirinixic acid
Oxidation-Reduction
Tretinoin
Fluorouracil
Endoplasmic Reticulum
Water
sodium arsenite
Hydralazine
Doxorubicin
Genistein
oxidoreductase activity
Endoplasmic reticulum, membrane
resveratrol
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Related concepts
#
|
Concept name
|
Type
|
Relation
|
Support
|
Score
|
1
|
CYP1A1 gene
|
Gene
|
Inferred
|
Explain
|
0.29155
|
2
|
CYP2C19 gene
|
Gene
|
Inferred
|
Explain
|
0.17487
|
3
|
CYP2D6 gene
|
Gene
|
Inferred
|
Explain
|
0.15886
|
4
|
CYP3A4 gene
|
Gene
|
Inferred
|
Explain
|
0.13746
|
5
|
CYP2E1 gene
|
Gene
|
Inferred
|
Explain
|
0.13554
|
6
|
CYP2B6 gene
|
Gene
|
Inferred
|
Explain
|
0.12178
|
7
|
CYP2C9 gene
|
Gene
|
Inferred
|
Explain
|
0.12153
|
8
|
CYP1B1 gene
|
Gene
|
Inferred
|
Explain
|
0.11888
|
9
|
CYP2A6 gene
|
Gene
|
Inferred
|
Explain
|
0.10124
|
10
|
CYP2C8 gene
|
Gene
|
Inferred
|
Explain
|
0.08607
|
11
|
CYP3A5 gene
|
Gene
|
Inferred
|
Explain
|
0.08049
|
12
|
CYP2C18 gene
|
Gene
|
Inferred
|
Explain
|
0.07580
|
13
|
CYP2A13 gene
|
Gene
|
Inferred
|
Explain
|
0.07357
|
14
|
CYP2S1 gene
|
Gene
|
Inferred
|
Explain
|
0.07154
|
15
|
CYP2A7 gene
|
Gene
|
Inferred
|
Explain
|
0.06971
|
16
|
CYP4B1 gene
|
Gene
|
Inferred
|
Explain
|
0.06951
|
17
|
CYP2F1 gene
|
Gene
|
Inferred
|
Explain
|
0.06907
|
18
|
CYP4X1 gene
|
Gene
|
Inferred
|
Explain
|
0.06886
|
19
|
CYP4Z1 gene
|
Gene
|
Inferred
|
Explain
|
0.06868
|
20
|
CYP3A43 gene
|
Gene
|
Inferred
|
Explain
|
0.06841
|
21
|
CYP2J2 gene
|
Gene
|
Inferred
|
Explain
|
0.06486
|
22
|
CYP3A7 gene
|
Gene
|
Inferred
|
Explain
|
0.06383
|
23
|
CYP19A1 gene
|
Gene
|
Inferred
|
Explain
|
0.04703
|
24
|
Primaquine
|
Compound
|
Known
|
Explain
|
0.01988
|
25
|
Aminoquinolines
|
Compound
|
Known
|
Explain
|
0.01932
|
26
|
Amodiaquine
|
Compound
|
Known
|
Explain
|
0.01917
|
27
|
AHR gene
|
Gene
|
Inferred
|
Explain
|
0.01785
|
28
|
tegaserod
|
Compound
|
Known
|
Explain
|
0.01757
|
29
|
Seglor
|
Compound
|
Known
|
Explain
|
0.01757
|
30
|
7H-dibenzo(c,g)carbazole
|
Compound
|
Known
|
Explain
|
0.01757
|
31
|
furafylline
|
Compound
|
Known
|
Explain
|
0.01757
|
32
|
N-methyl-7H-dibenzo(c,g)carbazole
|
Compound
|
Known
|
Explain
|
0.01757
|
33
|
propachlor
|
Compound
|
Known
|
Explain
|
0.01757
|
34
|
tangeretin
|
Compound
|
Known
|
Explain
|
0.01757
|
35
|
566C
|
Compound
|
Known
|
Explain
|
0.01757
|
36
|
2,7-dinitrofluorene
|
Compound
|
Known
|
Explain
|
0.01757
|
37
|
E 3810
|
Compound
|
Known
|
Explain
|
0.01757
|
38
|
4-nitroquinolone-1-oxide
|
Compound
|
Known
|
Explain
|
0.01757
|
39
|
Naphthalene
|
Compound
|
Known
|
Explain
|
0.01750
|
40
|
Hydroxytamoxifen
|
Compound
|
Known
|
Explain
|
0.01750
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41
|
alpha-Hydroxy fatty acid
|
Compound
|
Known
|
Explain
|
0.01750
|
42
|
19-Hydroxyandrost-4-ene-3,17-dione
|
Compound
|
Known
|
Explain
|
0.01750
|
43
|
7alpha-Hydroxytestosterone
|
Compound
|
Known
|
Explain
|
0.01750
|
44
|
19-Hydroxytestosterone
|
Compound
|
Known
|
Explain
|
0.01750
|
45
|
19-Oxotestosterone
|
Compound
|
Known
|
Explain
|
0.01750
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46
|
7alpha-Hydroxyandrost-4-ene-3,17-dione
|
Compound
|
Known
|
Explain
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0.01750
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47
|
19-Oxoandrost-4-ene-3,17-dione
|
Compound
|
Known
|
Explain
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0.01750
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48
|
6-Hydroxymelatonin
|
Compound
|
Known
|
Explain
|
0.01750
|
49
|
Carbamazepine-10,11-epoxide
|
Compound
|
Known
|
Explain
|
0.01750
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50
|
Felbamate
|
Compound
|
Known
|
Explain
|
0.01750
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51
|
4-Hydroxycyclophosphamide
|
Compound
|
Known
|
Explain
|
0.01750
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52
|
4-Ketocyclophosphamide
|
Compound
|
Known
|
Explain
|
0.01750
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53
|
Levomethadyl acetate
|
Compound
|
Known
|
Explain
|
0.01750
|
54
|
Bromobenzene
|
Compound
|
Known
|
Explain
|
0.01750
|
55
|
TCE epoxide
|
Compound
|
Known
|
Explain
|
0.01750
|
56
|
beta-Naphthol
|
Compound
|
Known
|
Explain
|
0.01750
|
57
|
Normorphine
|
Compound
|
Known
|
Explain
|
0.01750
|
58
|
1,1-Dichloroethylene
|
Compound
|
Known
|
Explain
|
0.01750
|
59
|
1-Nitronaphthalene
|
Compound
|
Known
|
Explain
|
0.01750
|
60
|
4-Bromophenol
|
Compound
|
Known
|
Explain
|
0.01750
|
61
|
9-Hydroxybenzo[a]pyrene
|
Compound
|
Known
|
Explain
|
0.01750
|
62
|
19(S)-HETE
|
Compound
|
Known
|
Explain
|
0.01750
|
63
|
16(R)-HETE
|
Compound
|
Known
|
Explain
|
0.01750
|
64
|
15H-11,12-EETA
|
Compound
|
Known
|
Explain
|
0.01750
|
65
|
11,12,15-THETA
|
Compound
|
Known
|
Explain
|
0.01750
|
66
|
1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene
|
Compound
|
Known
|
Explain
|
0.01750
|
67
|
11H-14,15-EETA
|
Compound
|
Known
|
Explain
|
0.01750
|
68
|
11,14,15-THETA
|
Compound
|
Known
|
Explain
|
0.01750
|
69
|
9(10)-EpOME
|
Compound
|
Known
|
Explain
|
0.01750
|
70
|
12(13)-EpOME
|
Compound
|
Known
|
Explain
|
0.01750
|
71
|
4-Bromophenol-2,3-epoxide
|
Compound
|
Known
|
Explain
|
0.01750
|
72
|
Benzo[a]pyrene-9,10-oxide
|
Compound
|
Known
|
Explain
|
0.01750
|
73
|
9-Hydroxybenzo[a]pyrene-4,5-oxide
|
Compound
|
Known
|
Explain
|
0.01750
|
74
|
Chloral
|
Compound
|
Known
|
Explain
|
0.01750
|
75
|
APC
|
Compound
|
Known
|
Explain
|
0.01750
|
76
|
alpha-Hydroxytamoxifen
|
Compound
|
Known
|
Explain
|
0.01750
|
77
|
N-Desmethyltamoxifen
|
Compound
|
Known
|
Explain
|
0.01750
|
78
|
4-Hydroxy-N-desmethyltamoxifen
|
Compound
|
Known
|
Explain
|
0.01750
|
79
|
N,N-Didesmethyltamoxifen
|
Compound
|
Known
|
Explain
|
0.01750
|
80
|
alpha-Hydroxy-N-desmethyltamoxifen
|
Compound
|
Known
|
Explain
|
0.01750
|
81
|
Dechloroethylcyclophosphamide
|
Compound
|
Known
|
Explain
|
0.01750
|
82
|
4-Hydroxyifosfamide
|
Compound
|
Known
|
Explain
|
0.01750
|
83
|
2-Dechloroethylifosfamide
|
Compound
|
Known
|
Explain
|
0.01750
|
84
|
3-Hydroxylidocaine
|
Compound
|
Known
|
Explain
|
0.01750
|
85
|
Norcodeine
|
Compound
|
Known
|
Explain
|
0.01750
|
86
|
2-Hydroxyfelbamate
|
Compound
|
Known
|
Explain
|
0.01750
|
87
|
p-Hydroxyfelbamate
|
Compound
|
Known
|
Explain
|
0.01750
|
88
|
2-Hydroxycarbamazepine
|
Compound
|
Known
|
Explain
|
0.01750
|
89
|
3-Hydroxycarbamazepine
|
Compound
|
Known
|
Explain
|
0.01750
|
90
|
2-Hydroxyiminostilbene
|
Compound
|
Known
|
Explain
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0.01750
|
91
|
Citalopram N-oxide
|
Compound
|
Known
|
Explain
|
0.01750
|
92
|
2-n-Propyl-4-pentenoic acid
|
Compound
|
Known
|
Explain
|
0.01750
|
93
|
4-Hydroxyvalproic acid
|
Compound
|
Known
|
Explain
|
0.01750
|
94
|
5-Hydroxyvalproic acid
|
Compound
|
Known
|
Explain
|
0.01750
|
95
|
3-Hydroxyvalproic acid
|
Compound
|
Known
|
Explain
|
0.01750
|
96
|
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
|
Compound
|
Known
|
Explain
|
0.01750
|
97
|
2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
|
Compound
|
Known
|
Explain
|
0.01750
|
98
|
L-alpha-Acetyl-N-normethadol
|
Compound
|
Known
|
Explain
|
0.01750
|
99
|
L-alpha-Acetyl-N,N-dinormethadol
|
Compound
|
Known
|
Explain
|
0.01750
|
100
|
all-trans-4-Hydroxyretinoic acid
|
Compound
|
Known
|
Explain
|
0.01750
|
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