inhibition of adenylate cyclase activity by dopamine receptor signaling pathway

Function • C1155422

Definition

The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP. [GOC:dph, GOC:mah, GOC:tb]

Synonyms

inhibition of adenylate cyclase activity by dopamine receptor signaling pathway • inhibition of adenylate cyclase activity by dopamine receptor signalling pathway • dopamine receptor, adenylate cyclase inhibiting pathway • dopamine receptor, adenylyl cyclase inhibiting pathway

Linked items?Related concepts, ordered by their global importance in the network.

FLNA gene    DRD2 gene    DRD3 gene    DRD4 gene    ADCY5 gene    inhibition of adenylate cyclase activity by G-protein signaling pathway    dopamine receptor signaling pathway    consequence of signal transmission   

Related concepts

# Concept name Type Relation Support Score
1 consequence of signal transmission Function Known Explain 43.17215
2 dopamine receptor signaling pathway Function Known Explain 32.71069
3 ADCY5 gene Gene Known Explain 12.44743
4 inhibition of adenylate cyclase activity by G-protein signaling pathway Function Known Explain 12.17173
5 DRD4 gene Gene Known Explain 9.14533
6 DRD3 gene Gene Known Explain 5.64034
7 DRD2 gene Gene Known Explain 3.93922
8 FLNA gene Gene Known Explain 3.70807
9 activation of adenylate cyclase activity by dopamine receptor signaling pathway Function Inferred Explain 1.41321
10 activation of phospholipase C activity by dopamine receptor signaling pathway Function Inferred Explain 1.29442
11 regulation of gene expression as a consequence of signal transmission Function Inferred Explain 1.00319
12 signaling process Function Inferred Explain 0.73670
13 D1 dopamine receptor-interacting, calcyon Domain Inferred Explain 0.19342
14 CALY gene Gene Inferred Explain 0.14211
15 KLF16 gene Gene Inferred Explain 0.12468
16 dopamine receptor activity, coupled via Gi/Go Function Inferred Explain 0.07168
17 RGS9 gene Gene Inferred Explain 0.06290
18 generation of a signal involved in cell-cell signaling Function Inferred Explain 0.04734
19 termination of signal transduction Function Inferred Explain 0.04633
20 initiation of signal transduction Function Inferred Explain 0.04431
21 DRD1 gene Gene Inferred Explain 0.03904
22 signal transmission Function Inferred Explain 0.03846
23 GNAO1 gene Gene Inferred Explain 0.03816
24 receptor recycling Function Inferred Explain 0.03386
25 DRD5 gene Gene Inferred Explain 0.03346
26 GNAL gene Gene Inferred Explain 0.03221
27 signal release Function Inferred Explain 0.02949
28 Dopamine receptor Domain Inferred Explain 0.02945
29 negative regulation of adenylate cyclase activity Function Inferred Explain 0.02426
30 response to histamine Function Inferred Explain 0.02417
31 behavioral response to cocaine Other Inferred Explain 0.02295
32 activation of adenylate cyclase activity by G-protein signaling pathway Function Inferred Explain 0.02165
33 dopamine receptor activity Function Inferred Explain 0.02136
34 signal initiation by diffusible mediator Function Inferred Explain 0.01972
35 termination of T cell signal transduction Function Inferred Explain 0.01916
36 dopamine D4 receptor activity Function Inferred Explain 0.01883
37 ADCY2 gene Gene Inferred Explain 0.01703
38 dopamine metabolic process Function Inferred Explain 0.01698
39 OPRM1 gene Gene Inferred Explain 0.01692
40 inhibition of adenylate cyclase activity by opioid receptor signaling pathway Function Inferred Explain 0.01670
41 HTT gene Gene Inferred Explain 0.01665
42 arachidonic acid secretion Function Inferred Explain 0.01661
43 positive regulation of dopamine uptake Function Inferred Explain 0.01499
44 response to amphetamine Function Inferred Explain 0.01457
45 inhibition of adenylate cyclase activity by serotonin receptor signaling pathway Function Inferred Explain 0.01420
46 CLIC6 gene Gene Inferred Explain 0.01408
47 inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway Function Inferred Explain 0.01385
48 negative regulation of protein secretion Function Inferred Explain 0.01350
49 GNAI1 gene Gene Inferred Explain 0.01319
50 inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway Function Inferred Explain 0.01257
51 behavioral response to ethanol Other Inferred Explain 0.01231
52 KCNJ9 gene Gene Inferred Explain 0.01231
53 G-protein coupled receptor protein signaling pathway Function Inferred Explain 0.01179
54 GNA14 gene Gene Inferred Explain 0.01161
55 Dopamine D4 receptor Domain Inferred Explain 0.01129
56 dopamine D3 receptor activity Function Inferred Explain 0.01099
57 Gene Expression Regulation Function Inferred Explain 0.01094
58 regulation of dopamine uptake Function Inferred Explain 0.01074
59 GNA15 gene Gene Inferred Explain 0.01013
60 negative regulation of calcium ion transport via voltage-gated calcium channel activity Function Inferred Explain 0.00993
61 KCNJ5 gene Gene Inferred Explain 0.00975
62 G-protein signaling, coupled to cAMP nucleotide second messenger Function Inferred Explain 0.00968
63 KCNJ3 gene Gene Inferred Explain 0.00950
64 7-hydroxy-2-N,N-dipropylaminotetralin Compound Inferred Explain 0.00937
65 AJ 76 Compound Inferred Explain 0.00937
66 CGS 15855A Compound Inferred Explain 0.00937
67 LY 163502 Compound Inferred Explain 0.00937
68 UH 232 Compound Inferred Explain 0.00937
69 U 99194A Compound Inferred Explain 0.00937
70 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan Compound Inferred Explain 0.00937
71 PD 128907 Compound Inferred Explain 0.00937
72 nafadotride Compound Inferred Explain 0.00937
73 3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole Compound Inferred Explain 0.00937
74 GR 218231 Compound Inferred Explain 0.00937
75 ADCY4 gene Gene Inferred Explain 0.00925
76 GNAS gene Gene Inferred Explain 0.00920
77 creation of an inductive signal Function Inferred Explain 0.00905
78 GNAZ gene Gene Inferred Explain 0.00897
79 negative regulation of dopamine receptor signaling pathway Function Inferred Explain 0.00895
80 ADCY1 gene Gene Inferred Explain 0.00891
81 adenosine receptor signaling pathway Function Inferred Explain 0.00875
82 Pramipexole Compound Inferred Explain 0.00866
83 SSTR5 gene Gene Inferred Explain 0.00864
84 dopamine receptor binding Function Inferred Explain 0.00855
85 Attention deficit hyperactivity disorder Disease Inferred Explain 0.00853
86 ADCY8 gene Gene Inferred Explain 0.00824
87 ADCY7 gene Gene Inferred Explain 0.00821
88 Adenylate cyclase-like Domain Inferred Explain 0.00814
89 CORT gene Gene Inferred Explain 0.00812
90 benzo(f)quinoline Compound Inferred Explain 0.00798
91 Piribedil Compound Inferred Explain 0.00776
92 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site Domain Inferred Explain 0.00772
93 ADCY9 gene Gene Inferred Explain 0.00766
94 synaptic transmission, dopaminergic Function Inferred Explain 0.00764
95 OPRL1 gene Gene Inferred Explain 0.00762
96 Adenylyl cyclase class-3/4/guanylyl cyclase Domain Inferred Explain 0.00748
97 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger Function Inferred Explain 0.00746
98 GNAI2 gene Gene Inferred Explain 0.00743
99 fear response Function Inferred Explain 0.00742
100 GNA11 gene Gene Inferred Explain 0.00741