G-protein coupled receptor activity

Function • C1152691

Definition

A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. [GOC:dph, GOC:tb, http://www.iupha

Synonyms

G-protein coupled receptor activity • G protein coupled receptor activity • G-protein-coupled receptor activity • G-protein coupled receptor activity, unknown ligand • orphan G-protein coupled receptor activity • orphan G protein coupled receptor activity • G protein linked receptor activity • G-protein linked receptor activity • GPCR activity • orphan GPCR activity

Linked items?Related concepts, ordered by their global importance in the network.

olfactory receptor activity    ADRB2 gene    transmembrane receptor activity    DRD2 gene    CXCR4 gene    CCR5 gene    DRD1 gene    DRD3 gene    F2R gene    HTR2A gene    AGTR1 gene    EDNRA gene    SMO gene    CCR2 gene    ADRB1 gene    ADRA2A gene    OXTR gene    GABBR1 gene    CHRM3 gene    TACR1 gene   

Related concepts

# Concept name Type Relation Support Score
1 G-protein coupled receptor protein signaling pathway Function Inferred Explain 0.21936
2 receptor activity Function Inferred Explain 0.16202
3 7TM GPCR, rhodopsin-like Domain Inferred Explain 0.12367
4 GPCR, rhodopsin-like superfamily Domain Inferred Explain 0.10238
5 Cell membrane Component Inferred Explain 0.10101
6 Neuroactive ligand-receptor interaction - Homo sapiens (human) Pathway Inferred Explain 0.06900
7 GPCR, family 2, secretin-like, conserved site Domain Known Explain 0.06745
8 integral to membrane Component Inferred Explain 0.06142
9 GPCR, family 2, secretin-like Domain Known Explain 0.05522
10 GPCR, family 2, extracellular region Domain Known Explain 0.05453
11 GPR orphan receptor Domain Known Explain 0.04828
12 neuropeptide signaling pathway Function Inferred Explain 0.04335
13 purinergic nucleotide receptor activity, G-protein coupled Function Inferred Explain 0.04330
14 GPCR, family 2, corticotropin releasing factor receptor Domain Known Explain 0.04078
15 integral to plasma membrane Component Inferred Explain 0.03990
16 GPCR, family 2-like Domain Inferred Explain 0.03726
17 GPR3 orphan receptor Domain Known Explain 0.03111
18 GPR6 gene Gene Known Explain 0.03045
19 GPR6 orphan receptor Domain Known Explain 0.03022
20 GPCR, family 2, corticotropin releasing factor receptor, type 1 Domain Known Explain 0.02979
21 GPCR, family 2, corticotropin releasing factor receptor, type 2 Domain Known Explain 0.02937
22 GPCR, family 2, latrophilin Domain Known Explain 0.02930
23 GPR3 gene Gene Known Explain 0.02835
24 GPCR, family 3 Domain Known Explain 0.02643
25 GPR4 gene Gene Known Explain 0.02585
26 Taste Perception Function Inferred Explain 0.02523
27 GPR4 orphan receptor Domain Known Explain 0.02469
28 GPCR, family 3, extracellular calcium-sensing receptor-related Domain Known Explain 0.02461
29 GPCR, family 2, latrophilin, C-terminal Domain Known Explain 0.02457
30 GPCR, family 2, EMR1 hormone receptor Domain Known Explain 0.02425
31 GPCR, family 3, conserved site Domain Known Explain 0.02414
32 GPCR, family 3, nine cysteines region Domain Known Explain 0.02398
33 GPR12 gene Gene Known Explain 0.02354
34 GLP2R gene Gene Known Explain 0.02322
35 LPHN3 gene Gene Known Explain 0.02313
36 bioactive lipid receptor activity Function Known Explain 0.02310
37 GPCR, family 2, secretin receptor Domain Known Explain 0.02308
38 GPCR, family 3, extracellular calcium-sensing receptor Domain Known Explain 0.02304
39 RXFP3 gene Gene Known Explain 0.02303
40 growth hormone secretagogue receptor activity Function Known Explain 0.02299
41 secretin receptor activity Function Known Explain 0.02293
42 thyrotropin-releasing hormone receptor activity Function Known Explain 0.02268
43 CGRP receptor activity Function Known Explain 0.02254
44 adenylate cyclase inhibiting metabotropic glutamate receptor activity Function Known Explain 0.02234
45 Methuselah, N-terminal Domain Known Explain 0.02219
46 glucagon receptor activity Function Known Explain 0.02214
47 GPCR, family 2, growth hormone-releasing hormone receptor Domain Known Explain 0.02209
48 G-protein coupled cytokinin receptor activity Function Known Explain 0.02207
49 GPCR, family 2, calcitonin gene-related peptide, type 1 receptor Domain Known Explain 0.02156
50 nicotinic acid receptor activity Function Known Explain 0.02131
51 melatonin receptor activity Function Known Explain 0.02130
52 lysosphingolipid and lysophosphatidic acid receptor activity Function Inferred Explain 0.02127
53 growth hormone-releasing hormone receptor activity Function Known Explain 0.02126
54 GPCR, family 3, C-terminal Domain Known Explain 0.02107
55 gastric inhibitory peptide receptor activity Function Known Explain 0.02100
56 GPR157 gene Gene Known Explain 0.02097
57 ecdysis-triggering hormone receptor activity Function Known Explain 0.02093
58 LPHN2 gene Gene Known Explain 0.02087
59 Mas transmembrane protein Domain Known Explain 0.02073
60 DEZ orphan receptor Domain Known Explain 0.02073
61 APJ receptor Domain Known Explain 0.02073
62 Mammalian taste receptor Domain Known Explain 0.02054
63 eicosanoid receptor activity Function Known Explain 0.02046
64 GPR174 gene Gene Known Explain 0.02028
65 nucleotide receptor activity, G-protein coupled Function Known Explain 0.02025
66 GPR97 gene Gene Known Explain 0.02024
67 GPR50 gene Gene Known Explain 0.02020
68 GPR101 gene Gene Known Explain 0.02008
69 GPBAR1 gene Gene Known Explain 0.02008
70 GPR153 gene Gene Known Explain 0.02008
71 GPR152 gene Gene Known Explain 0.02008
72 GPR148 gene Gene Known Explain 0.02008
73 GPR149 gene Gene Known Explain 0.02008
74 MRGPRG gene Gene Known Explain 0.02008
75 MRGPRD gene Gene Known Explain 0.02008
76 MRGPRE gene Gene Known Explain 0.02008
77 GPR179 gene Gene Known Explain 0.02008
78 MRGPRX3 gene Gene Known Explain 0.02008
79 MRGPRX4 gene Gene Known Explain 0.02008
80 corticotrophin-releasing factor receptor activity Function Known Explain 0.02006
81 GPR171 gene Gene Known Explain 0.01981
82 MLNR gene Gene Known Explain 0.01980
83 GPR144 gene Gene Known Explain 0.01970
84 GPR113 gene Gene Known Explain 0.01970
85 GPR111 gene Gene Known Explain 0.01970
86 GPR112 gene Gene Known Explain 0.01970
87 GPR114 gene Gene Known Explain 0.01970
88 GPR116 gene Gene Known Explain 0.01970
89 GPR128 gene Gene Known Explain 0.01970
90 EMR3 gene Gene Known Explain 0.01963
91 calcitonin receptor activity Function Known Explain 0.01959
92 GPR141 gene Gene Known Explain 0.01952
93 parathyroid hormone receptor activity Function Known Explain 0.01949
94 Retinal pigment epithelium GPCR Domain Known Explain 0.01944
95 GPR20 gene Gene Known Explain 0.01922
96 GPR21 gene Gene Known Explain 0.01922
97 GPR22 gene Gene Known Explain 0.01922
98 GPR31 gene Gene Known Explain 0.01922
99 GPR52 gene Gene Known Explain 0.01922
100 GPR75 gene Gene Known Explain 0.01922