protein-glutamine gamma-glutamyltransferase activity

Function • C1149592

Definition

Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of pepti

Synonyms

protein-glutamine gamma-glutamyltransferase activity • fibrinoligase activity • TGase activity • transglutaminase activity

Linked items?Related concepts, ordered by their global importance in the network.

TGM2 gene    TGM1 gene    F13A1 gene    EPB42 gene    TGM3 gene    TGM5 gene    TGM4 gene    TGM7 gene    Transglutaminase, C-terminal    TGM6 gene    aminoacyltransferase activity   

Related concepts

# Concept name Type Relation Support Score
1 Transglutaminase, C-terminal Domain Known Explain 26.32151
2 TGM6 gene Gene Known Explain 21.77511
3 TGM7 gene Gene Known Explain 20.03368
4 TGM4 gene Gene Known Explain 16.06196
5 aminoacyltransferase activity Function Known Explain 14.66551
6 TGM5 gene Gene Known Explain 14.25946
7 TGM3 gene Gene Known Explain 11.29279
8 EPB42 gene Gene Known Explain 9.83176
9 F13A1 gene Gene Known Explain 9.56367
10 TGM1 gene Gene Known Explain 7.38222
11 TGM2 gene Gene Known Explain 4.60448
12 Alkylamine Compound Inferred Explain 1.29708
13 Protein glutamine Compound Inferred Explain 1.29708
14 Protein N5-alkylglutamine Compound Inferred Explain 1.29708
15 Transglutaminase, conserved site Domain Inferred Explain 0.95138
16 Transglutaminase-like Domain Inferred Explain 0.88014
17 Transglutaminase, N-terminal Domain Inferred Explain 0.84098
18 peptide cross-linking Function Inferred Explain 0.47550
19 leucyltransferase activity Function Inferred Explain 0.37515
20 Ammonia Compound Inferred Explain 0.29254
21 glutaminyl-peptide cyclotransferase activity Function Inferred Explain 0.23639
22 transferase activity, transferring acyl groups Function Inferred Explain 0.22727
23 Immunoglobulin E-set Domain Inferred Explain 0.19994
24 gamma-glutamylcyclotransferase activity Function Inferred Explain 0.18729
25 glutathione gamma-glutamylcysteinyltransferase activity Function Inferred Explain 0.18664
26 arginyltransferase activity Function Inferred Explain 0.17533
27 gamma-glutamyltransferase activity Function Inferred Explain 0.15716
28 PEELING SKIN SYNDROME Disease Inferred Explain 0.13221
29 Leucyl/phenylalanyl-tRNA-protein transferase Domain Inferred Explain 0.12217
30 Peeling skin syndrome, acral type Disease Inferred Explain 0.09887
31 acyltransferase activity Function Inferred Explain 0.09827
32 protein amino acid polyamination Function Inferred Explain 0.05555
33 QPCT gene Gene Inferred Explain 0.05431
34 Immunoglobulin-like fold Domain Inferred Explain 0.04934
35 cell envelope organization Function Inferred Explain 0.04246
36 erythrocyte maturation Function Inferred Explain 0.03981
37 SPINK7 gene Gene Inferred Explain 0.03663
38 hemoglobin metabolic process Function Inferred Explain 0.03508
39 iron ion homeostasis Function Inferred Explain 0.03255
40 CNO gene Gene Inferred Explain 0.03227
41 ion homeostasis Function Inferred Explain 0.03158
42 Gamma-glutamylcyclotransferase Domain Inferred Explain 0.03055
43 GGCT gene Gene Inferred Explain 0.02770
44 EPB49 gene Gene Inferred Explain 0.02765
45 transferase activity Function Inferred Explain 0.02755
46 Peeling of skin Disease Inferred Explain 0.02578
47 Arginine-tRNA-protein transferase 1, eukaryotic Domain Inferred Explain 0.02513
48 Arginine-tRNA-protein transferase, N-terminal Domain Inferred Explain 0.02392
49 Arginine-tRNA-protein transferase, C-terminal Domain Inferred Explain 0.02392
50 A2LD1 gene Gene Inferred Explain 0.02258
51 Arginine-tRNA-protein transferase, predicted, prokaryotic Domain Inferred Explain 0.02161
52 SLC4A2 gene Gene Inferred Explain 0.02045
53 Spleen Development Function Inferred Explain 0.02016
54 ATE1 gene Gene Inferred Explain 0.02001
55 Cortical cytoskeleton Component Inferred Explain 0.01996
56 STX12 gene Gene Inferred Explain 0.01978
57 Congenital ichthyosis Disease Inferred Explain 0.01745
58 Keratinization, function Function Inferred Explain 0.01631
59 ANK2 gene Gene Inferred Explain 0.01493
60 keratinocyte differentiation Function Inferred Explain 0.01455
61 protein modification process Function Inferred Explain 0.01410
62 CD47 gene Gene Inferred Explain 0.01409
63 ANK1 gene Gene Inferred Explain 0.01281
64 Protein Degradation, Regulatory Function Inferred Explain 0.01114
65 F13B gene Gene Inferred Explain 0.01110
66 Metal Ion Binding Function Inferred Explain 0.01099
67 SLC4A1 gene Gene Inferred Explain 0.01078
68 Streptothricin acetyltransferase Domain Inferred Explain 0.01067
69 IGHA1 gene Gene Inferred Explain 0.01037
70 cell morphogenesis Function Inferred Explain 0.01005
71 GWT1 Domain Inferred Explain 0.00956
72 Congenital Nonbullous Ichthyosiform Erythroderma Other Inferred Explain 0.00949
73 Factor XIII Deficiency Disease Inferred Explain 0.00948
74 poly-N-methyl-propylamination Function Inferred Explain 0.00928
75 ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL, NONBULLOUS, 1 Disease Inferred Explain 0.00891
76 Iodoacetamide Compound Inferred Explain 0.00883
77 CALML5 gene Gene Inferred Explain 0.00872
78 structural constituent of cytoskeleton Function Inferred Explain 0.00852
79 Beta Carotene Compound Inferred Explain 0.00833
80 Phytochelatin synthase Domain Inferred Explain 0.00813
81 Phytochelatin synthase, C-terminal Domain Inferred Explain 0.00813
82 Dry Eye Syndromes Disease Inferred Explain 0.00809
83 SPTAN1 gene Gene Inferred Explain 0.00778
84 apocarotenal Compound Inferred Explain 0.00766
85 IGHG1 gene Gene Inferred Explain 0.00754
86 epidermis development Function Inferred Explain 0.00754
87 Regulation of Cell Shape Function Inferred Explain 0.00747
88 protein tetramerization Function Inferred Explain 0.00736
89 SERPINF2 gene Gene Inferred Explain 0.00720
90 hair follicle morphogenesis Function Inferred Explain 0.00685
91 NPS R-467 Compound Inferred Explain 0.00682
92 USP53 gene Gene Inferred Explain 0.00679
93 PIGW gene Gene Inferred Explain 0.00662
94 Vitamin A Deficiency Disease Inferred Explain 0.00622
95 extrinsic to internal side of plasma membrane Component Inferred Explain 0.00618
96 Gamma-glutamyltranspeptidase Domain Inferred Explain 0.00616
97 GDP binding Function Inferred Explain 0.00613
98 GGT2 gene Gene Inferred Explain 0.00589
99 Vitamin D Compound Inferred Explain 0.00586
100 protein arginylation Function Inferred Explain 0.00580