transcription factor activity

Function • C1148759

Definition

The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. [GOC:curators]

Synonyms

transcription factor activity • Transcription Factor Activity [MoA]

Linked items?Related concepts, ordered by their global importance in the network.

ESR1 gene    TP53 gene    MYC gene    ESR2 gene    RELA gene    AR gene    JUN gene    NFKB1 gene    SMAD2 gene    RB1 gene    FOS gene    HDAC1 gene    SMAD3 gene    CREBBP gene    NR3C1 gene    PPARG gene    SP1 gene    SMAD4 gene    STAT3 gene    HIF1A gene   

Related concepts

# Concept name Type Relation Support Score
1 regulation of transcription, DNA-dependent Function Inferred Explain 0.12965
2 sequence-specific DNA binding Function Inferred Explain 0.06240
3 Cell Nucleus Component Inferred Explain 0.05076
4 transcription, DNA-dependent Function Inferred Explain 0.04173
5 DNA Binding Function Inferred Explain 0.03392
6 Homeobox Domain Known Explain 0.03029
7 Homeodomain-related Domain Inferred Explain 0.02639
8 Homeodomain-like Domain Inferred Explain 0.02286
9 transcription regulator activity Function Inferred Explain 0.02120
10 Homeobox, conserved site Domain Inferred Explain 0.01875
11 Winged helix repressor DNA-binding Domain Inferred Explain 0.01640
12 RNA polymerase sigma factor, region 2 Domain Known Explain 0.01488
13 RNA polymerase sigma-70 region 2 Domain Known Explain 0.01322
14 zinc ion binding Function Inferred Explain 0.01261
15 Protoplasm Component Inferred Explain 0.01248
16 p53-like transcription factor, DNA-binding Domain Known Explain 0.01133
17 sigma factor activity Function Inferred Explain 0.01055
18 Metal Ion Binding Function Inferred Explain 0.01054
19 multicellular organismal development Function Inferred Explain 0.01016
20 RNA polymerase sigma factor, region 3/4 Domain Known Explain 0.00984
21 RNA polymerase sigma-70 Domain Known Explain 0.00953
22 RNA polymerase sigma-70 region 4 Domain Known Explain 0.00915
23 Helix-turn-helix motif, lambda-like repressor Domain Known Explain 0.00914
24 RNA polymerase sigma-70 factor Domain Known Explain 0.00894
25 Transcription factor, T-box, conserved site Domain Known Explain 0.00868
26 Transcription factor, T-box Domain Known Explain 0.00849
27 Transcription factor AP-2 Domain Known Explain 0.00832
28 Transcription Initiation Function Inferred Explain 0.00778
29 RNA polymerase sigma factor 70, region 4 type 2 Domain Known Explain 0.00740
30 RNA polymerase sigma-70 region 3 Domain Known Explain 0.00737
31 RNA polymerase sigma-B/F/G type Domain Known Explain 0.00707
32 positive regulation of transcription from RNA polymerase II promoter Function Inferred Explain 0.00694
33 Ets Domain Known Explain 0.00690
34 RNA polymerase sigma factor RpoS, proteobacteria Domain Known Explain 0.00625
35 Arginine repressor Domain Known Explain 0.00600
36 transcription factor complex Component Inferred Explain 0.00599
37 RNA polymerase sigma factor 70, ECF, conserved site Domain Known Explain 0.00588
38 transcription activator activity Function Inferred Explain 0.00566
39 RNA polymerase sigma-G type Domain Known Explain 0.00564
40 RNA polymerase sigma-F type Domain Known Explain 0.00564
41 Basic-leucine zipper (bZIP) transcription factor Domain Known Explain 0.00560
42 STAT transcription factor, core Domain Known Explain 0.00554
43 Transcriptional Regulation Function Inferred Explain 0.00539
44 negative regulation of transcription from RNA polymerase II promoter Function Inferred Explain 0.00527
45 Zinc finger, C2H2-like Domain Inferred Explain 0.00524
46 RNA polymerase sigma-70 RpoE type Domain Known Explain 0.00520
47 RNA polymerase sigma-70, actinobacteria Domain Known Explain 0.00520
48 Zinc finger, C2H2-type Domain Inferred Explain 0.00519
49 Transcription regulator, AsnC-type Domain Known Explain 0.00518
50 Transcription factor AP-2 beta, N-terminal Domain Known Explain 0.00514
51 Transcription factor AP-2 gamma Domain Known Explain 0.00514
52 RNA polymerase sigma-E type Domain Known Explain 0.00513
53 RNA polymerase sigma-K type Domain Known Explain 0.00513
54 Protein Binding Function Inferred Explain 0.00512
55 Fungal transcriptional regulatory protein, N-terminal Domain Known Explain 0.00512
56 Helix-turn-helix, AraC type, subdomain 2 Domain Known Explain 0.00510
57 Transcription factor Otx Domain Known Explain 0.00506
58 Zinc finger, C2H2-type/integrase, DNA-binding Domain Inferred Explain 0.00504
59 transcription from RNA polymerase II promoter Function Inferred Explain 0.00501
60 p53 tumour antigen Domain Known Explain 0.00499
61 Transcription factor Otx, C-terminal Domain Known Explain 0.00499
62 p53, DNA-binding Domain Known Explain 0.00498
63 Transcription regulator Crp-type HTH, conserved site Domain Known Explain 0.00493
64 Transcription factor, Brachyury Domain Known Explain 0.00491
65 RBPJL gene Gene Known Explain 0.00490
66 bZIP transcription factor, bZIP-1 Domain Known Explain 0.00488
67 Homeobox, region Domain Inferred Explain 0.00485
68 Bacterial regulatory protein, Crp Domain Known Explain 0.00481
69 RNA polymerase sigma factor RpoH, proteobacteria Domain Known Explain 0.00479
70 IPR022783 Domain Known Explain 0.00475
71 RNA polymerase sigma-H type Domain Known Explain 0.00471
72 Transcription regulator, AsnC-type, HTH domain, conserved site Domain Known Explain 0.00470
73 Transcription factor AP-2 alpha, N-terminal Domain Known Explain 0.00466
74 Viral life cycle Function Inferred Explain 0.00464
75 GC-rich sequence DNA-binding factor-like Domain Known Explain 0.00463
76 Transcription regulator, AsnC-type, HTH domain Domain Known Explain 0.00460
77 p53/RUNT-type transcription factor, DNA-binding domain Domain Known Explain 0.00459
78 Transcription regulator Myc Domain Known Explain 0.00459
79 IPR022299 Domain Known Explain 0.00457
80 RNA polymerase sigma-M, bacillaceae Domain Known Explain 0.00456
81 Transcription factor Otx1, C-terminal Domain Known Explain 0.00454
82 Fatty acid response transcription factor FadR Domain Known Explain 0.00452
83 HTH transcriptional regulator Rot Domain Known Explain 0.00451
84 RNA polymerase sigma-70 region 1.2 Domain Known Explain 0.00446
85 regulation of transcription from RNA polymerase II promoter Function Inferred Explain 0.00444
86 IPR020899 Domain Known Explain 0.00441
87 Homeobox protein, antennapedia type Domain Known Explain 0.00428
88 Bacterial regulatory protein, MarR Domain Known Explain 0.00427
89 Heat shock factor (HSF)-type, DNA-binding Domain Known Explain 0.00425
90 Helix-turn-helix, AraC domain Domain Known Explain 0.00424
91 Transcription regulator, HTH DeoR-type, conserved site Domain Known Explain 0.00424
92 DM DNA-binding Domain Known Explain 0.00424
93 Bacterial regulatory protein, DeoR N-terminal Domain Known Explain 0.00423
94 IPR020900 Domain Known Explain 0.00423
95 GCFC1 gene Gene Known Explain 0.00422
96 Transcription factor Otx2 Domain Known Explain 0.00420
97 Homeobox protein, antennapedia type, conserved site Domain Known Explain 0.00415
98 IPR022689 Domain Known Explain 0.00408
99 MEIS1 gene Gene Known Explain 0.00405
100 MYCL2 gene Gene Known Explain 0.00404