DNA Binding

Function • C1148673

Definition

Used in reference to proteins or low molecular weight solutes (ligands) that interact specifically with DNA, in either a DNA-sequence dependent or independent fashion.

Synonyms

DNA Binding • DNA Binding Interaction

Linked items?Related concepts, ordered by their global importance in the network.

TP53 gene    MAPK1 gene    MYC gene    ESR2 gene    RELA gene    AR gene    sequence-specific DNA binding    JUN gene    EP300 gene    NFKB1 gene    SMAD2 gene    RB1 gene    ABL1 gene    Nucleic Acid Binding    PARP1 gene    ALB gene    BRCA1 gene    ERBB2 gene    APP gene    PRKDC gene   

Related concepts

# Concept name Type Relation Support Score
1 Cell Nucleus Component Inferred Explain 0.06901
2 regulation of transcription, DNA-dependent Function Inferred Explain 0.05892
3 zinc ion binding Function Inferred Explain 0.04517
4 Protoplasm Component Inferred Explain 0.03935
5 Metal Ion Binding Function Inferred Explain 0.03668
6 Transcriptional Regulation Function Inferred Explain 0.02689
7 transcription factor activity Function Inferred Explain 0.01880
8 DNA restriction-modification system Function Inferred Explain 0.01828
9 type II site-specific deoxyribonuclease activity Function Inferred Explain 0.01683
10 DNA-directed RNA polymerase activity Function Inferred Explain 0.01489
11 Chromosomes Component Inferred Explain 0.01078
12 Transcription, Genetic Function Inferred Explain 0.00999
13 DNA topological change Function Inferred Explain 0.00976
14 Zinc finger, C2H2-like Domain Inferred Explain 0.00901
15 nucleosome location Component Inferred Explain 0.00880
16 Zinc finger, C2H2-type/integrase, DNA-binding Domain Inferred Explain 0.00878
17 Zinc finger, C2H2-type Domain Inferred Explain 0.00866
18 transcription, DNA-dependent Function Inferred Explain 0.00845
19 DNA biosynthesis Function Inferred Explain 0.00830
20 transposition, DNA-mediated Function Inferred Explain 0.00729
21 transposase activity Function Inferred Explain 0.00706
22 DNA topoisomerase activity Function Known Explain 0.00605
23 transcription regulator activity Function Inferred Explain 0.00583
24 nucleosome assembly Function Inferred Explain 0.00548
25 RNA polymerase sigma factor, region 2 Domain Known Explain 0.00497
26 Winged helix repressor DNA-binding Domain Inferred Explain 0.00482
27 Protein Binding Function Inferred Explain 0.00482
28 DNA-directed DNA polymerase activity Function Inferred Explain 0.00476
29 RNA polymerase sigma-70 region 2 Domain Known Explain 0.00465
30 Restriction endonuclease, type II-like, core Domain Known Explain 0.00450
31 Transcription Initiation Function Inferred Explain 0.00448
32 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide Compound Inferred Explain 0.00447
33 DNA Integration Function Inferred Explain 0.00425
34 Cyclosporine Compound Inferred Explain 0.00423
35 DNA topoisomerase (ATP-hydrolyzing) activity Function Inferred Explain 0.00420
36 DNA topoisomerase, type IA, central Domain Known Explain 0.00420
37 DNA topoisomerase, type IA, core Domain Known Explain 0.00411
38 Krueppel-associated box Domain Inferred Explain 0.00409
39 DNA topoisomerase, type IIA, central Domain Known Explain 0.00402
40 sigma factor activity Function Inferred Explain 0.00401
41 DNA topoisomerase, type IA, DNA-binding Domain Known Explain 0.00387
42 Recombination, Genetic Function Inferred Explain 0.00374
43 DNA topoisomerase, type IA, central region, subdomain 1 Domain Known Explain 0.00361
44 Cytoplasm Component Inferred Explain 0.00352
45 RNA polymerase sigma-70 factor Domain Known Explain 0.00342
46 IPR020816 Domain Known Explain 0.00333
47 DNA topoisomerase, type IA, domain 2 Domain Known Explain 0.00332
48 multicellular organismal development Function Inferred Explain 0.00332
49 RNA polymerase sigma factor, region 3/4 Domain Known Explain 0.00327
50 RNA polymerase sigma-70 region 4 Domain Known Explain 0.00325
51 Histone-like bacterial DNA-binding protein Domain Known Explain 0.00312
52 RNA polymerase Rpb1, domain 5 Domain Known Explain 0.00305
53 DNA topoisomerase I, C-terminal, eukaryotic-type Domain Known Explain 0.00303
54 IHF-like DNA-binding Domain Known Explain 0.00302
55 Homeodomain-like Domain Inferred Explain 0.00297
56 DNA topoisomerase I, C-terminal Domain Known Explain 0.00294
57 ATP binding Function Inferred Explain 0.00291
58 RNA polymerase sigma-70 Domain Known Explain 0.00290
59 DNA Repair Function Inferred Explain 0.00283
60 DNA topoisomerase, type IIA, subunit A or C-terminal Domain Known Explain 0.00279
61 DNA breaking-rejoining enzyme, catalytic core Domain Known Explain 0.00279
62 Helix-turn-helix, Psq-like Domain Known Explain 0.00278
63 DNA topoisomerase I, archeal-type Domain Known Explain 0.00277
64 DNA-directed RNA polymerase, beta subunit, bacterial-type Domain Known Explain 0.00273
65 DNA topoisomerase I, bacterial-type Domain Known Explain 0.00268
66 Nucleoplasm Component Inferred Explain 0.00268
67 transcription activator activity Function Inferred Explain 0.00268
68 Histone core Domain Known Explain 0.00268
69 transcription repressor activity Function Inferred Explain 0.00267
70 Transcription elongation factor, GreA/GreB, conserved site Domain Known Explain 0.00264
71 DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta Domain Known Explain 0.00260
72 sequence-specific DNA binding Function Known Explain 0.00254
73 DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type Domain Known Explain 0.00252
74 RNA polymerase sigma-70 region 3 Domain Known Explain 0.00251
75 DNA topoisomerase, type IIA, subunit B or N-terminal Domain Known Explain 0.00249
76 High mobility group, HMG1/HMG2 Domain Known Explain 0.00249
77 DNA-directed RNA polymerase, subunit B, archaea Domain Known Explain 0.00245
78 DNA-directed RNA polymerase, subunit beta-prime Domain Known Explain 0.00243
79 DNA topoisomerase III, bacterial-type Domain Known Explain 0.00240
80 DNA-binding protein Tfx, euryarchaeota Domain Known Explain 0.00239
81 Restriction endonuclease, type II, EcoRI Domain Known Explain 0.00238
82 AT hook, DNA-binding motif Domain Known Explain 0.00237
83 RNA polymerase sigma factor 70, region 4 type 2 Domain Known Explain 0.00236
84 endonuclease activity Function Inferred Explain 0.00236
85 DNA topoisomerase, type IIA, conserved site Domain Known Explain 0.00235
86 TOP3A gene Gene Known Explain 0.00235
87 Benzo(a)pyrene Compound Inferred Explain 0.00233
88 DNA topoisomerase I activity Function Inferred Explain 0.00231
89 positive regulation of transcription Function Inferred Explain 0.00229
90 DNA topoisomerase, type IIA, subunit B Domain Known Explain 0.00229
91 DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta Domain Known Explain 0.00228
92 Homeodomain-related Domain Known Explain 0.00226
93 Integrase, catalytic core, phage Domain Known Explain 0.00225
94 RNA polymerase Rpb1, domain 3 Domain Known Explain 0.00225
95 Reverse gyrase Domain Known Explain 0.00225
96 Basic helix-loop-helix dimerisation region bHLH Domain Inferred Explain 0.00221
97 DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type Domain Known Explain 0.00220
98 DNA topoisomerase I, catalytic core, eukaryotic-type Domain Known Explain 0.00219
99 RNA polymerase, N-terminal Domain Known Explain 0.00219
100 DNA polymerase A domain Domain Known Explain 0.00217