zafirlukast

Compound • C0378466

Definition

A toyl compound with anti-asthmatic property. Zafirlukast selectively and competitively binds and blocks the cysteinyl leukotriene 1 receptor , thereby preventing potent proinflammatory mediators leukotriene C4, D4 and E4 from binding. This prevents leuko

Synonyms

zafirlukast • 4-(5-cyclopentyloxycarbonylamino-2-methylindol-3-yl-methyl)-3-methoxy-N-O-tolylsulfonylbenzamide • Carbamic Acid,(3-((2-methoxy-4-((((2-methylphenyl)sulfonyl)amino)carbonyl)phenyl)methyl)-1-methyl-1H-indol-5-yl)-, Cyclopentyl Ester • Cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate • zafirlukast [Chemical/Ingredient]

Linked items?Related concepts, ordered by their global importance in the network.

TNF gene    CYP3A4 gene    SRC gene    CYP1A2 gene    IL6 gene    IL8 gene    CYP2E1 gene    CYP2C9 gene    CYP2C19 gene    CYP2D6 gene    CYP2C8 gene    IFNG gene    ABCC1 gene    EDN1 gene    Hepatitis, Toxic    Inflammation    Asthma    Pain    SELP gene    IL13 gene   

Related concepts

# Concept name Type Relation Support Score
1 Decompression Sickness Disease Known Explain 1.29423
2 Candidiasis of vagina Disease Known Explain 1.13496
3 Pharyngitis Disease Known Explain 0.96497
4 Lung Diseases, Obstructive Disease Known Explain 0.93008
5 Allergic Conjunctivitis Disease Known Explain 0.85587
6 Churg-Strauss Syndrome Disease Known Explain 0.82933
7 Asthma, Exercise-Induced Disease Known Explain 0.82530
8 Chronic Obstructive Airway Disease Disease Known Explain 0.77260
9 Nasal Polyps Other Known Explain 0.74864
10 Allergic rhinitis (disorder) Disease Known Explain 0.73044
11 Leukocytosis Disease Known Explain 0.73016
12 Pulmonary Edema Disease Known Explain 0.66892
13 Asthma, Aspirin-Induced Disease Known Explain 0.59413
14 LTB4R2 gene Gene Known Explain 0.54365
15 Sinusitis Disease Known Explain 0.54182
16 Nausea Disease Known Explain 0.53900
17 RNASE3 gene Gene Known Explain 0.52951
18 Headache Disease Known Explain 0.52040
19 Bronchial Diseases Disease Known Explain 0.50615
20 CYSLTR2 gene Gene Known Explain 0.49756
21 Endometriosis, site unspecified Disease Known Explain 0.49516
22 Coughing Disease Known Explain 0.47645
23 Necrosis Disease Known Explain 0.47562
24 Rhinitis Disease Known Explain 0.42802
25 Eosinophilia Disease Known Explain 0.42286
26 zileuton Compound Inferred Explain 0.38193
27 Ayerza Syndrome Disease Known Explain 0.34511
28 CYSLTR1 gene Gene Known Explain 0.33402
29 Vasculitis Disease Known Explain 0.33258
30 Hepatitis Disease Known Explain 0.31891
31 Asthma Disease Known Explain 0.29793
32 Pancreatitis Disease Known Explain 0.28625
33 Urticaria Disease Known Explain 0.28260
34 Cervical Migraine Syndrome Disease Known Explain 0.28255
35 Dermatitis, Atopic Disease Known Explain 0.26965
36 Cystic Fibrosis Disease Known Explain 0.26961
37 Reperfusion Injury Other Known Explain 0.22753
38 Dysbarism Other Inferred Explain 0.20419
39 IL13 gene Gene Known Explain 0.17451
40 Pain Disease Known Explain 0.16000
41 Edema Disease Known Explain 0.15925
42 Leukotrienes Compound Inferred Explain 0.13645
43 SELP gene Gene Known Explain 0.13582
44 Inflammation Disease Known Explain 0.12622
45 BAY u 3406 Compound Inferred Explain 0.11018
46 Hepatitis, Toxic Other Known Explain 0.10821
47 Nasopharyngitis Disease Inferred Explain 0.09642
48 Rabbit Aorta Contracting Substance Compound Inferred Explain 0.09212
49 Bronchitis Disease Inferred Explain 0.08966
50 Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Disease Inferred Explain 0.08816
51 montelukast Compound Inferred Explain 0.08714
52 Tonsillitis Disease Inferred Explain 0.08260
53 Retropharyngeal Abscess Disease Inferred Explain 0.07516
54 ABCC1 gene Gene Known Explain 0.07475
55 ASTHMA, NASAL POLYPS, AND ASPIRIN INTOLERANCE Disease Inferred Explain 0.06822
56 EDN1 gene Gene Known Explain 0.06517
57 CYP2C8 gene Gene Known Explain 0.06488
58 Leukotrienes E Compound Inferred Explain 0.06280
59 Adrenal Cortex Hormones Compound Inferred Explain 0.06051
60 Pharyngeal Diseases Disease Inferred Explain 0.05831
61 CYP2C19 gene Gene Known Explain 0.05781
62 CYP2D6 gene Gene Known Explain 0.05630
63 Respiratory Tract Infections Disease Inferred Explain 0.05460
64 IFNG gene Gene Known Explain 0.05459
65 CYP2C9 gene Gene Known Explain 0.05201
66 Granuloma Disease Inferred Explain 0.05191
67 CYP2E1 gene Gene Known Explain 0.05116
68 IL8 gene Gene Known Explain 0.04670
69 TNF gene Gene Known Explain 0.04396
70 LTF gene Gene Inferred Explain 0.04167
71 Nose Diseases Disease Inferred Explain 0.04117
72 Immediate hypersensitivity Disease Inferred Explain 0.04108
73 CYP1A2 gene Gene Known Explain 0.04092
74 IL6 gene Gene Known Explain 0.04033
75 CYP3A4 gene Gene Known Explain 0.04023
76 Peritonsillar Abscess Disease Inferred Explain 0.03888
77 polyps Other Inferred Explain 0.03700
78 Lung diseases Disease Inferred Explain 0.03635
79 Nasopharyngeal Diseases Disease Inferred Explain 0.03553
80 5,12-diHETE Compound Inferred Explain 0.03319
81 Conjunctivitis Disease Inferred Explain 0.03074
82 SRC gene Gene Known Explain 0.02901
83 Abscess Disease Inferred Explain 0.02782
84 Beclomethasone Compound Inferred Explain 0.02531
85 Phosgene Compound Inferred Explain 0.02503
86 Bronchial Hyperreactivity Disease Inferred Explain 0.02494
87 HYPERTHERMIA, CUTANEOUS, WITH HEADACHES AND NAUSEA Disease Inferred Explain 0.02444
88 salmeterol Compound Inferred Explain 0.02421
89 leukotriene receptor activity Function Inferred Explain 0.02391
90 Sumatriptan Compound Inferred Explain 0.02233
91 Caerulein Compound Inferred Explain 0.02045
92 ONO-RS 411 Compound Inferred Explain 0.02011
93 Bronchial Spasm Disease Inferred Explain 0.01949
94 Paranasal Sinus Diseases Disease Inferred Explain 0.01891
95 Bronchiectasis Disease Inferred Explain 0.01692
96 KWD-2019 Compound Inferred Explain 0.01640
97 Slit Ventricle Syndrome Disease Inferred Explain 0.01566
98 Kartagener Syndrome Disease Inferred Explain 0.01558
99 Hydrocodone Compound Inferred Explain 0.01538
100 Bronchial Neoplasms Disease Inferred Explain 0.01535