aripiprazole

Compound • C0299792

Definition

A quinoline derivate and atypical anti-psychotic agent. Aripiprazole has partial agonistic activity at dopamine D2 receptors and serotonin 5-HT1A receptors, as well as potent antagonistic activity on serotonin 5-HT2A receptors. This drug stabilizes dopami

Synonyms

aripiprazole • 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone • 2(1H)-Quinolinone, 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro- • aripiprazole [Chemical/Ingredient]

Linked items?Related concepts, ordered by their global importance in the network.

Autistic Disorder    DRD2 gene    Schizophrenia    HTR2A gene    Profound Mental Retardation    Behavior Disorders    PRL gene    HTR1A gene    Attention Deficit Disorder    Psychosis, Brief Reactive    Child Development Disorders, Pervasive    Asperger Syndrome   

Related concepts

# Concept name Type Relation Support Score
1 Asperger Syndrome Disease Known Explain 19.07685
2 Child Development Disorders, Pervasive Disease Known Explain 16.03905
3 Psychosis, Brief Reactive Disease Known Explain 9.46478
4 Attention Deficit Disorder Disease Known Explain 8.87676
5 HTR1A gene Gene Known Explain 7.95580
6 PRL gene Gene Known Explain 5.95276
7 Behavior Disorders Disease Known Explain 4.83873
8 Profound Mental Retardation Disease Known Explain 4.24160
9 HTR2A gene Gene Known Explain 3.03674
10 Schizophrenia Disease Known Explain 2.08742
11 Autistic Disorder Disease Known Explain 1.26590
12 DRD2 gene Gene Known Explain 1.22882
13 Methylphenidate Compound Inferred Explain 0.64109
14 Chlorprothixene Compound Inferred Explain 0.40535
15 Risperidone Compound Inferred Explain 0.32728
16 topiramate Compound Inferred Explain 0.29196
17 Mental Disorders Diagnosed in Childhood Disease Inferred Explain 0.25689
18 Citalopram Compound Inferred Explain 0.25100
19 Methionine Compound Inferred Explain 0.21978
20 Perazine Compound Inferred Explain 0.20154
21 ASPERGER SYNDROME, X-LINKED, SUSCEPTIBILITY TO, 2 (finding) Disease Inferred Explain 0.19190
22 ASPERGER SYNDROME, X-LINKED, SUSCEPTIBILITY TO, 1 (disorder) Disease Inferred Explain 0.18504
23 HTR1B gene Gene Inferred Explain 0.12316
24 atomoxetine Compound Inferred Explain 0.11937
25 Guanfacine Compound Inferred Explain 0.10762
26 PVALB gene Gene Inferred Explain 0.09762
27 Sonapax Compound Inferred Explain 0.08971
28 Desipramine Compound Inferred Explain 0.08474
29 Haloperidol Compound Inferred Explain 0.07622
30 DRD5 gene Gene Inferred Explain 0.07485
31 Delsym Compound Inferred Explain 0.07410
32 CPLX1 gene Gene Inferred Explain 0.07320
33 inhibition of adenylate cyclase activity by serotonin receptor signaling pathway Function Inferred Explain 0.06534
34 Axon hillock Component Inferred Explain 0.06289
35 serotonin binding Function Inferred Explain 0.06284
36 CPLX2 gene Gene Inferred Explain 0.05786
37 Clozapine Compound Inferred Explain 0.05274
38 SLC6A4 gene Gene Inferred Explain 0.05218
39 HTR1D gene Gene Inferred Explain 0.05212
40 5-HT receptor activity Function Inferred Explain 0.05162
41 G-protein alpha-subunit binding Function Inferred Explain 0.04953
42 Fluoxetine Compound Inferred Explain 0.04935
43 Oxidopamine Compound Inferred Explain 0.04583
44 Dibenzazepines Compound Inferred Explain 0.04567
45 WHSC2 gene Gene Inferred Explain 0.04424
46 Phthalic Acids Compound Inferred Explain 0.04370
47 GPR26 gene Gene Inferred Explain 0.04289
48 Cocaine Compound Inferred Explain 0.04142
49 quetiapine Compound Inferred Explain 0.04019
50 Pesticides Compound Inferred Explain 0.03978
51 Cisordinol Compound Inferred Explain 0.03861
52 BDNF gene Gene Inferred Explain 0.03808
53 CP 88059 Compound Inferred Explain 0.03696
54 Opipramol Compound Inferred Explain 0.03678
55 Trimipramine Compound Inferred Explain 0.03678
56 Eperythrozoonosis Disease Inferred Explain 0.03629
57 SELENBP1 gene Gene Inferred Explain 0.03388
58 reboxetine mesylate Compound Inferred Explain 0.03325
59 Methotrimeprazine Compound Inferred Explain 0.03300
60 Phenothiazines Compound Inferred Explain 0.03176
61 Paroxetine Compound Inferred Explain 0.03149
62 regulation of feeding behavior Other Inferred Explain 0.03143
63 TPH2 gene Gene Inferred Explain 0.03055
64 Fatty Acids, Omega-6 Compound Inferred Explain 0.03034
65 SLC6A3 gene Gene Inferred Explain 0.02977
66 Endogenous depression Disease Inferred Explain 0.02944
67 Perphenazine Compound Inferred Explain 0.02904
68 Fluvoxamine Compound Inferred Explain 0.02899
69 Benperidol Compound Inferred Explain 0.02883
70 Mianserin Compound Inferred Explain 0.02840
71 Moclobemide Compound Inferred Explain 0.02798
72 Viloxazine Compound Inferred Explain 0.02739
73 norfluoxetine Compound Inferred Explain 0.02736
74 DRD4 gene Gene Inferred Explain 0.02668
75 SNAP25 gene Gene Inferred Explain 0.02622
76 Nortriptyline Compound Inferred Explain 0.02505
77 Fluanxol Compound Inferred Explain 0.02465
78 DISC1 gene Gene Inferred Explain 0.02451
79 EPILEPSY, X-LINKED, WITH VARIABLE LEARNING DISABILITIES AND BEHAVIOR DISORDERS Disease Inferred Explain 0.02404
80 Mirtazapine Compound Inferred Explain 0.02325
81 Omega-3 Fatty Acids Compound Inferred Explain 0.02323
82 S1PR3 gene Gene Inferred Explain 0.02309
83 Developmental Disabilities Disease Inferred Explain 0.02296
84 Fluphenazine Compound Inferred Explain 0.02282
85 Sulpiride Compound Inferred Explain 0.02183
86 TACR1 gene Gene Inferred Explain 0.02113
87 Pimozide Compound Inferred Explain 0.02063
88 HTR2C gene Gene Inferred Explain 0.02026
89 drug binding Function Inferred Explain 0.01923
90 S1PR1 gene Gene Inferred Explain 0.01899
91 Phenylacetates Compound Inferred Explain 0.01851
92 LY 170053 Compound Inferred Explain 0.01834
93 serotonin receptor signaling pathway Function Inferred Explain 0.01786
94 GABBR2 gene Gene Inferred Explain 0.01726
95 NTRK1 gene Gene Inferred Explain 0.01706
96 NLGN4X gene Gene Inferred Explain 0.01629
97 GRIN1 gene Gene Inferred Explain 0.01597
98 Doxepin Compound Inferred Explain 0.01591
99 DGCR8 gene Gene Inferred Explain 0.01465
100 Chlorpromazine Compound Inferred Explain 0.01462