Losartan

Compound • C0126174

Definition

The potassium salt form of losartan, a non-peptide angiotensin II antagonist with antihypertensive activity. Losartan potassium selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor. Angiotensin II, formed

Synonyms

Losartan • lozartan • 2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol • 2-Butyl-4-chloro-1-((2''-(1H-etrazol-5-yl) (1,1''-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol • 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol • Losartan [Chemical/Ingredient]

Linked items?Related concepts, ordered by their global importance in the network.

CYP2C9 gene    ICAM1 gene    Liver Cirrhosis, Experimental    AGT gene    Inflammation    Hypertensive disease    AGTR1 gene    Myocardial Infarction    Atherosclerosis    Heart failure    Cardiomegaly    SLC22A9 gene    Imidazoles    Kidney Failure    Marfan Syndrome    Biphenyl Compounds    Albuminuria    Tetrazoles   

Related concepts

# Concept name Type Relation Support Score
1 Tetrazoles Compound Known Explain 13.79028
2 Albuminuria Disease Known Explain 9.84619
3 Biphenyl Compounds Compound Known Explain 7.51036
4 Kidney Failure Disease Known Explain 4.71833
5 Marfan Syndrome Disease Known Explain 4.60887
6 Cefotetan Compound Inferred Explain 3.84715
7 Imidazoles Compound Known Explain 3.23206
8 Cardiomegaly Disease Known Explain 2.19073
9 SLC22A9 gene Gene Known Explain 2.09414
10 Heart failure Disease Known Explain 2.01635
11 Atherosclerosis Disease Known Explain 1.52510
12 Myocardial Infarction Disease Known Explain 1.51524
13 Azoles Compound Inferred Explain 1.43566
14 Cephamycins Compound Inferred Explain 1.38303
15 AGTR1 gene Gene Known Explain 1.13551
16 Hypertensive disease Disease Known Explain 0.93708
17 Inflammation Disease Known Explain 0.76845
18 AGT gene Gene Known Explain 0.72215
19 Cephalosporins Compound Inferred Explain 0.56053
20 ICAM1 gene Gene Known Explain 0.50041
21 Liver Cirrhosis, Experimental Disease Known Explain 0.48288
22 CYP2C9 gene Gene Known Explain 0.33653
23 Niclofolan Compound Inferred Explain 0.33429
24 Clofenapate Compound Inferred Explain 0.32263
25 3,3-Dichlorobenzidine Compound Inferred Explain 0.31754
26 Dianisidine Compound Inferred Explain 0.29054
27 Proteinuria Disease Inferred Explain 0.27905
28 Polybrominated Biphenyls Compound Inferred Explain 0.19359
29 LEPR gene Gene Inferred Explain 0.18746
30 C1835866 Other Inferred Explain 0.12784
31 Atenolol Compound Inferred Explain 0.12178
32 Benzene Derivatives Compound Inferred Explain 0.12174
33 Nitrophenols Compound Inferred Explain 0.11099
34 Flurbiprofen Compound Inferred Explain 0.10667
35 Isoxazoles Compound Inferred Explain 0.08391
36 Fibrates Compound Inferred Explain 0.08326
37 Thiazoles Compound Inferred Explain 0.07031
38 Cephaloridine Compound Inferred Explain 0.06705
39 Cephacetrile Compound Inferred Explain 0.05944
40 Coronary Thrombosis Disease Inferred Explain 0.05317
41 Triazoles Compound Inferred Explain 0.04830
42 Imidazolidines Compound Inferred Explain 0.04419
43 Niridazole Compound Inferred Explain 0.04194
44 Tetramisole Compound Inferred Explain 0.04194
45 Cefazolin Compound Inferred Explain 0.04059
46 Oxymetazoline Compound Inferred Explain 0.03875
47 FBN1 gene Gene Inferred Explain 0.03800
48 Imidazolines Compound Inferred Explain 0.03779
49 Thiazines Compound Inferred Explain 0.03744
50 Enalapril Compound Inferred Explain 0.03704
51 Pyrazoles Compound Inferred Explain 0.03655
52 Impromidine Compound Inferred Explain 0.03569
53 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone Compound Inferred Explain 0.03557
54 Dexmedetomidine Compound Inferred Explain 0.03544
55 Histidinol Compound Inferred Explain 0.03517
56 Fadrozole Compound Inferred Explain 0.03491
57 Oxazoles Compound Inferred Explain 0.03475
58 Econazole Compound Inferred Explain 0.03402
59 Connective Tissue Diseases Disease Inferred Explain 0.03354
60 LAMB1 gene Gene Inferred Explain 0.03198
61 Nitroimidazoles Compound Inferred Explain 0.03192
62 Idazoxan Compound Inferred Explain 0.03169
63 Pyrroles Compound Inferred Explain 0.03085
64 Raloxifene Compound Inferred Explain 0.03081
65 Phentolamine Compound Inferred Explain 0.03052
66 Fluspirilene Compound Inferred Explain 0.03041
67 Bone Diseases, Developmental Disease Inferred Explain 0.02998
68 Etomidate Compound Inferred Explain 0.02943
69 Ondansetron Compound Inferred Explain 0.02561
70 Cefotaxime Compound Inferred Explain 0.02431
71 Urocanic Acid Compound Inferred Explain 0.02319
72 RENAL FAILURE, PROGRESSIVE, WITH HYPERTENSION Disease Inferred Explain 0.02287
73 Genetic Diseases, Inborn Disease Inferred Explain 0.02178
74 Ceftazidime Compound Inferred Explain 0.02170
75 beta-Lactams Compound Inferred Explain 0.02086
76 Levamisole Compound Inferred Explain 0.02062
77 Methimazole Compound Inferred Explain 0.02020
78 Heterocyclic Compounds, 1-Ring Compound Inferred Explain 0.01934
79 Polychlorinated Biphenyls Compound Inferred Explain 0.01931
80 Isoproterenol Compound Inferred Explain 0.01859
81 Congenital Heart Defects Other Inferred Explain 0.01855
82 Biotin Compound Inferred Explain 0.01811
83 Clotrimazole Compound Inferred Explain 0.01686
84 valsartan Compound Inferred Explain 0.01669
85 Multiple congenital anomalies Other Inferred Explain 0.01618
86 X-linked recessive nephrolithiasis with renal failure Disease Inferred Explain 0.01508
87 CI 981 Compound Inferred Explain 0.01493
88 Cimetidine Compound Inferred Explain 0.01439
89 2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionic acid Compound Inferred Explain 0.01269
90 Doxazosin Mesylate Compound Inferred Explain 0.01121
91 NPPB gene Gene Inferred Explain 0.01100
92 2-Hydroxy-5-nitrobenzyl Bromide Compound Inferred Explain 0.01075
93 Nitro Compounds Compound Inferred Explain 0.01067
94 Left Ventricular Hypertrophy Disease Inferred Explain 0.01059
95 Hydantoins Compound Inferred Explain 0.01001
96 Dinitrophenols Compound Inferred Explain 0.00977
97 Benzyl Compounds Compound Inferred Explain 0.00965
98 Ramipril Compound Inferred Explain 0.00951
99 BMS 207940 Compound Inferred Explain 0.00925
100 OR 1259 Compound Inferred Explain 0.00919