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Shiga Toxin
Compound • C0074447
Definition
A bacterial toxin produced by Shigella dysenteriae and by some strains of E. coli that inhibits protein synthesis by blocking the interaction of ribosomal RNA with peptide elongation factors. The non-catalytic beta subunit of Shiga toxin may be useful as
Synonyms
Shiga Toxin • Toxin, Shiga • Shigella Cytotoxin • Cytotoxin, Shigella • Shigella Toxin • Toxin, Shigella • Stx Protein • Stx Protein, Shigella dysenteria • Shiga Toxin [Chemical/Ingredient]
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MAPK1 gene
TNF gene
MAPK3 gene
NFKB1 gene
IL8 gene
FOS gene
IL1B gene
ADRB2 gene
Shiga Toxins
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Related concepts
#
|
Concept name
|
Type
|
Relation
|
Support
|
Score
|
1
|
Shiga Toxins
|
Compound
|
Known
|
Explain
|
24.86928
|
2
|
ADRB2 gene
|
Gene
|
Known
|
Explain
|
2.45880
|
3
|
NFKB1 gene
|
Gene
|
Known
|
Explain
|
1.29290
|
4
|
FOS gene
|
Gene
|
Known
|
Explain
|
1.28753
|
5
|
IL1B gene
|
Gene
|
Known
|
Explain
|
1.15718
|
6
|
IL8 gene
|
Gene
|
Known
|
Explain
|
1.13004
|
7
|
MAPK3 gene
|
Gene
|
Known
|
Explain
|
0.99268
|
8
|
MAPK1 gene
|
Gene
|
Known
|
Explain
|
0.88088
|
9
|
TNF gene
|
Gene
|
Known
|
Explain
|
0.75272
|
10
|
Ribosome Inactivating Proteins, Type 2
|
Compound
|
Inferred
|
Explain
|
0.50715
|
11
|
Shiga Toxin 1
|
Compound
|
Inferred
|
Explain
|
0.43032
|
12
|
Enterotoxins
|
Compound
|
Inferred
|
Explain
|
0.33326
|
13
|
Shiga Toxin 2
|
Compound
|
Inferred
|
Explain
|
0.30570
|
14
|
Bacterial Toxins
|
Compound
|
Inferred
|
Explain
|
0.24930
|
15
|
Plant Lectins
|
Compound
|
Inferred
|
Explain
|
0.13585
|
16
|
Abrin
|
Compound
|
Inferred
|
Explain
|
0.07675
|
17
|
Ricin
|
Compound
|
Inferred
|
Explain
|
0.06704
|
18
|
RNA glycosylase
|
Compound
|
Inferred
|
Explain
|
0.04017
|
19
|
Toxin
|
Compound
|
Inferred
|
Explain
|
0.03035
|
20
|
Cholera Toxin
|
Compound
|
Inferred
|
Explain
|
0.03005
|
21
|
Escherichia coli Proteins
|
Compound
|
Inferred
|
Explain
|
0.02324
|
22
|
Streptolysins
|
Compound
|
Inferred
|
Explain
|
0.01396
|
23
|
Exfoliatins
|
Compound
|
Inferred
|
Explain
|
0.01279
|
24
|
Wheat Germ Agglutinins
|
Compound
|
Inferred
|
Explain
|
0.01156
|
25
|
Exotoxins
|
Compound
|
Inferred
|
Explain
|
0.01031
|
26
|
Diphtheria Toxin
|
Compound
|
Inferred
|
Explain
|
0.00950
|
27
|
Virulence Factors, Bordetella
|
Compound
|
Inferred
|
Explain
|
0.00928
|
28
|
Cord Factors
|
Compound
|
Inferred
|
Explain
|
0.00902
|
29
|
Tetanus Toxin
|
Compound
|
Inferred
|
Explain
|
0.00885
|
30
|
Plant Proteins
|
Compound
|
Inferred
|
Explain
|
0.00880
|
31
|
GUCY2C gene
|
Gene
|
Inferred
|
Explain
|
0.00811
|
32
|
Bacterial Proteins
|
Compound
|
Inferred
|
Explain
|
0.00786
|
33
|
NPR3 gene
|
Gene
|
Inferred
|
Explain
|
0.00779
|
34
|
Albumins
|
Compound
|
Inferred
|
Explain
|
0.00747
|
35
|
Botulinum Toxins
|
Compound
|
Inferred
|
Explain
|
0.00728
|
36
|
Endotoxins
|
Compound
|
Inferred
|
Explain
|
0.00724
|
37
|
N-Glycosyl Hydrolases
|
Compound
|
Inferred
|
Explain
|
0.00714
|
38
|
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
|
Compound
|
Inferred
|
Explain
|
0.00632
|
39
|
Phytohemagglutinins
|
Compound
|
Inferred
|
Explain
|
0.00595
|
40
|
Lectin
|
Compound
|
Inferred
|
Explain
|
0.00432
|
41
|
RELA gene
|
Gene
|
Inferred
|
Explain
|
0.00414
|
42
|
ADP Ribose Transferases
|
Compound
|
Inferred
|
Explain
|
0.00396
|
43
|
IL6 gene
|
Gene
|
Inferred
|
Explain
|
0.00374
|
44
|
CCL2 gene
|
Gene
|
Inferred
|
Explain
|
0.00306
|
45
|
Horseradish Peroxidase
|
Compound
|
Inferred
|
Explain
|
0.00286
|
46
|
Pore Forming Cytotoxic Proteins
|
Compound
|
Inferred
|
Explain
|
0.00264
|
47
|
Protein Binding
|
Function
|
Inferred
|
Explain
|
0.00251
|
48
|
Glycolipids
|
Compound
|
Inferred
|
Explain
|
0.00243
|
49
|
ADRB3 gene
|
Gene
|
Inferred
|
Explain
|
0.00238
|
50
|
Diarrhea
|
Disease
|
Inferred
|
Explain
|
0.00235
|
51
|
Pertussis Toxin
|
Compound
|
Inferred
|
Explain
|
0.00225
|
52
|
KWD-2019
|
Compound
|
Inferred
|
Explain
|
0.00225
|
53
|
CFTR gene
|
Gene
|
Inferred
|
Explain
|
0.00221
|
54
|
PTGS2 gene
|
Gene
|
Inferred
|
Explain
|
0.00210
|
55
|
CASP3 gene
|
Gene
|
Inferred
|
Explain
|
0.00205
|
56
|
Lipopolysaccharides
|
Compound
|
Inferred
|
Explain
|
0.00195
|
57
|
formoterol
|
Compound
|
Inferred
|
Explain
|
0.00183
|
58
|
Cell Nucleus
|
Component
|
Inferred
|
Explain
|
0.00178
|
59
|
Clonidine
|
Compound
|
Inferred
|
Explain
|
0.00175
|
60
|
bufalin
|
Compound
|
Inferred
|
Explain
|
0.00170
|
61
|
ICI 118551
|
Compound
|
Inferred
|
Explain
|
0.00161
|
62
|
NFKBIA gene
|
Gene
|
Inferred
|
Explain
|
0.00159
|
63
|
Virulence Factors
|
Compound
|
Inferred
|
Explain
|
0.00154
|
64
|
Cytoplasm
|
Component
|
Inferred
|
Explain
|
0.00153
|
65
|
JUN gene
|
Gene
|
Inferred
|
Explain
|
0.00152
|
66
|
Cyclosporine
|
Compound
|
Inferred
|
Explain
|
0.00150
|
67
|
epinephrine hydrochloride
|
Compound
|
Inferred
|
Explain
|
0.00150
|
68
|
ADRB1 gene
|
Gene
|
Inferred
|
Explain
|
0.00149
|
69
|
Mucoproteins
|
Compound
|
Inferred
|
Explain
|
0.00147
|
70
|
Peroxidases
|
Compound
|
Inferred
|
Explain
|
0.00146
|
71
|
CCL5 gene
|
Gene
|
Inferred
|
Explain
|
0.00146
|
72
|
MAPK8 gene
|
Gene
|
Inferred
|
Explain
|
0.00142
|
73
|
AKT1 gene
|
Gene
|
Inferred
|
Explain
|
0.00141
|
74
|
Dicumarol
|
Compound
|
Inferred
|
Explain
|
0.00141
|
75
|
colicin
|
Compound
|
Inferred
|
Explain
|
0.00136
|
76
|
2,2',4,6,6'-pentachlorobiphenyl
|
Compound
|
Inferred
|
Explain
|
0.00136
|
77
|
IFNG gene
|
Gene
|
Inferred
|
Explain
|
0.00134
|
78
|
CYP1A1 gene
|
Gene
|
Inferred
|
Explain
|
0.00132
|
79
|
CSF2 gene
|
Gene
|
Inferred
|
Explain
|
0.00130
|
80
|
Benzo(a)pyrene
|
Compound
|
Inferred
|
Explain
|
0.00127
|
81
|
Ionomycin
|
Compound
|
Inferred
|
Explain
|
0.00127
|
82
|
Tetrachlorodibenzodioxin
|
Compound
|
Inferred
|
Explain
|
0.00126
|
83
|
BCL2 gene
|
Gene
|
Inferred
|
Explain
|
0.00125
|
84
|
Albuterol
|
Compound
|
Inferred
|
Explain
|
0.00125
|
85
|
Estradiol
|
Compound
|
Inferred
|
Explain
|
0.00124
|
86
|
Histamine
|
Compound
|
Inferred
|
Explain
|
0.00122
|
87
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
|
Compound
|
Inferred
|
Explain
|
0.00122
|
88
|
Cell membrane
|
Component
|
Inferred
|
Explain
|
0.00121
|
89
|
TP53 gene
|
Gene
|
Inferred
|
Explain
|
0.00119
|
90
|
IL10 gene
|
Gene
|
Inferred
|
Explain
|
0.00119
|
91
|
Adhesins, Escherichia coli
|
Compound
|
Inferred
|
Explain
|
0.00115
|
92
|
Isoproterenol
|
Compound
|
Inferred
|
Explain
|
0.00113
|
93
|
MMP9 gene
|
Gene
|
Inferred
|
Explain
|
0.00113
|
94
|
diphenyleneiodonium
|
Compound
|
Inferred
|
Explain
|
0.00110
|
95
|
moxifloxacin
|
Compound
|
Inferred
|
Explain
|
0.00108
|
96
|
Tetradecanoylphorbol Acetate
|
Compound
|
Inferred
|
Explain
|
0.00108
|
97
|
arsenic trioxide
|
Compound
|
Inferred
|
Explain
|
0.00108
|
98
|
Th-1165a
|
Compound
|
Inferred
|
Explain
|
0.00108
|
99
|
tulobuterol
|
Compound
|
Inferred
|
Explain
|
0.00107
|
100
|
salmeterol
|
Compound
|
Inferred
|
Explain
|
0.00106
|
|