Shiga Toxin

Compound • C0074447

Definition

A bacterial toxin produced by Shigella dysenteriae and by some strains of E. coli that inhibits protein synthesis by blocking the interaction of ribosomal RNA with peptide elongation factors. The non-catalytic beta subunit of Shiga toxin may be useful as

Synonyms

Shiga Toxin • Toxin, Shiga • Shigella Cytotoxin • Cytotoxin, Shigella • Shigella Toxin • Toxin, Shigella • Stx Protein • Stx Protein, Shigella dysenteria • Shiga Toxin [Chemical/Ingredient]

Linked items?Related concepts, ordered by their global importance in the network.

MAPK1 gene    TNF gene    MAPK3 gene    NFKB1 gene    IL8 gene    FOS gene    IL1B gene    ADRB2 gene    Shiga Toxins   

Related concepts

# Concept name Type Relation Support Score
1 Shiga Toxins Compound Known Explain 24.86928
2 ADRB2 gene Gene Known Explain 2.45880
3 NFKB1 gene Gene Known Explain 1.29290
4 FOS gene Gene Known Explain 1.28753
5 IL1B gene Gene Known Explain 1.15718
6 IL8 gene Gene Known Explain 1.13004
7 MAPK3 gene Gene Known Explain 0.99268
8 MAPK1 gene Gene Known Explain 0.88088
9 TNF gene Gene Known Explain 0.75272
10 Ribosome Inactivating Proteins, Type 2 Compound Inferred Explain 0.50715
11 Shiga Toxin 1 Compound Inferred Explain 0.43032
12 Enterotoxins Compound Inferred Explain 0.33326
13 Shiga Toxin 2 Compound Inferred Explain 0.30570
14 Bacterial Toxins Compound Inferred Explain 0.24930
15 Plant Lectins Compound Inferred Explain 0.13585
16 Abrin Compound Inferred Explain 0.07675
17 Ricin Compound Inferred Explain 0.06704
18 RNA glycosylase Compound Inferred Explain 0.04017
19 Toxin Compound Inferred Explain 0.03035
20 Cholera Toxin Compound Inferred Explain 0.03005
21 Escherichia coli Proteins Compound Inferred Explain 0.02324
22 Streptolysins Compound Inferred Explain 0.01396
23 Exfoliatins Compound Inferred Explain 0.01279
24 Wheat Germ Agglutinins Compound Inferred Explain 0.01156
25 Exotoxins Compound Inferred Explain 0.01031
26 Diphtheria Toxin Compound Inferred Explain 0.00950
27 Virulence Factors, Bordetella Compound Inferred Explain 0.00928
28 Cord Factors Compound Inferred Explain 0.00902
29 Tetanus Toxin Compound Inferred Explain 0.00885
30 Plant Proteins Compound Inferred Explain 0.00880
31 GUCY2C gene Gene Inferred Explain 0.00811
32 Bacterial Proteins Compound Inferred Explain 0.00786
33 NPR3 gene Gene Inferred Explain 0.00779
34 Albumins Compound Inferred Explain 0.00747
35 Botulinum Toxins Compound Inferred Explain 0.00728
36 Endotoxins Compound Inferred Explain 0.00724
37 N-Glycosyl Hydrolases Compound Inferred Explain 0.00714
38 Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate Compound Inferred Explain 0.00632
39 Phytohemagglutinins Compound Inferred Explain 0.00595
40 Lectin Compound Inferred Explain 0.00432
41 RELA gene Gene Inferred Explain 0.00414
42 ADP Ribose Transferases Compound Inferred Explain 0.00396
43 IL6 gene Gene Inferred Explain 0.00374
44 CCL2 gene Gene Inferred Explain 0.00306
45 Horseradish Peroxidase Compound Inferred Explain 0.00286
46 Pore Forming Cytotoxic Proteins Compound Inferred Explain 0.00264
47 Protein Binding Function Inferred Explain 0.00251
48 Glycolipids Compound Inferred Explain 0.00243
49 ADRB3 gene Gene Inferred Explain 0.00238
50 Diarrhea Disease Inferred Explain 0.00235
51 Pertussis Toxin Compound Inferred Explain 0.00225
52 KWD-2019 Compound Inferred Explain 0.00225
53 CFTR gene Gene Inferred Explain 0.00221
54 PTGS2 gene Gene Inferred Explain 0.00210
55 CASP3 gene Gene Inferred Explain 0.00205
56 Lipopolysaccharides Compound Inferred Explain 0.00195
57 formoterol Compound Inferred Explain 0.00183
58 Cell Nucleus Component Inferred Explain 0.00178
59 Clonidine Compound Inferred Explain 0.00175
60 bufalin Compound Inferred Explain 0.00170
61 ICI 118551 Compound Inferred Explain 0.00161
62 NFKBIA gene Gene Inferred Explain 0.00159
63 Virulence Factors Compound Inferred Explain 0.00154
64 Cytoplasm Component Inferred Explain 0.00153
65 JUN gene Gene Inferred Explain 0.00152
66 Cyclosporine Compound Inferred Explain 0.00150
67 epinephrine hydrochloride Compound Inferred Explain 0.00150
68 ADRB1 gene Gene Inferred Explain 0.00149
69 Mucoproteins Compound Inferred Explain 0.00147
70 Peroxidases Compound Inferred Explain 0.00146
71 CCL5 gene Gene Inferred Explain 0.00146
72 MAPK8 gene Gene Inferred Explain 0.00142
73 AKT1 gene Gene Inferred Explain 0.00141
74 Dicumarol Compound Inferred Explain 0.00141
75 colicin Compound Inferred Explain 0.00136
76 2,2',4,6,6'-pentachlorobiphenyl Compound Inferred Explain 0.00136
77 IFNG gene Gene Inferred Explain 0.00134
78 CYP1A1 gene Gene Inferred Explain 0.00132
79 CSF2 gene Gene Inferred Explain 0.00130
80 Benzo(a)pyrene Compound Inferred Explain 0.00127
81 Ionomycin Compound Inferred Explain 0.00127
82 Tetrachlorodibenzodioxin Compound Inferred Explain 0.00126
83 BCL2 gene Gene Inferred Explain 0.00125
84 Albuterol Compound Inferred Explain 0.00125
85 Estradiol Compound Inferred Explain 0.00124
86 Histamine Compound Inferred Explain 0.00122
87 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide Compound Inferred Explain 0.00122
88 Cell membrane Component Inferred Explain 0.00121
89 TP53 gene Gene Inferred Explain 0.00119
90 IL10 gene Gene Inferred Explain 0.00119
91 Adhesins, Escherichia coli Compound Inferred Explain 0.00115
92 Isoproterenol Compound Inferred Explain 0.00113
93 MMP9 gene Gene Inferred Explain 0.00113
94 diphenyleneiodonium Compound Inferred Explain 0.00110
95 moxifloxacin Compound Inferred Explain 0.00108
96 Tetradecanoylphorbol Acetate Compound Inferred Explain 0.00108
97 arsenic trioxide Compound Inferred Explain 0.00108
98 Th-1165a Compound Inferred Explain 0.00108
99 tulobuterol Compound Inferred Explain 0.00107
100 salmeterol Compound Inferred Explain 0.00106