|
Thromboxanes
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Compound • C0040061
Definition
Physiologically active compounds found in many organs of the body. They are formed in vivo from the prostaglandin endoperoxides and cause platelet aggregation, contraction of arteries, and other biological effects. Thromboxanes are important mediators of
Synonyms
Thromboxanes • thromboxane • Thromboxanes [Chemical/Ingredient]
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|
Arachidonic Acids
Eicosanoids
Thromboxane A2
Thromboxane B2
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Related concepts
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#
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Concept name
|
Type
|
Relation
|
Support
|
Score
|
|
1
|
Thromboxane B2
|
Compound
|
Known
|
Explain
|
288.55212
|
|
2
|
Thromboxane A2
|
Compound
|
Known
|
Explain
|
282.20802
|
|
3
|
Eicosanoids
|
Compound
|
Known
|
Explain
|
187.46713
|
|
4
|
Arachidonic Acids
|
Compound
|
Known
|
Explain
|
153.77408
|
|
5
|
TBXAS1 gene
|
Gene
|
Inferred
|
Explain
|
29.01808
|
|
6
|
Prostaglandins
|
Compound
|
Inferred
|
Explain
|
7.36989
|
|
7
|
Fatty Acids, Unsaturated
|
Compound
|
Inferred
|
Explain
|
7.08175
|
|
8
|
Leukotrienes
|
Compound
|
Inferred
|
Explain
|
5.41449
|
|
9
|
Fatty Acids, Essential
|
Compound
|
Inferred
|
Explain
|
5.25851
|
|
10
|
Isoprostanes
|
Compound
|
Inferred
|
Explain
|
3.76527
|
|
11
|
Hydroxyeicosatetraenoic Acids
|
Compound
|
Inferred
|
Explain
|
3.37705
|
|
12
|
PTGS2 gene
|
Gene
|
Inferred
|
Explain
|
2.93497
|
|
13
|
LTB4R2 gene
|
Gene
|
Inferred
|
Explain
|
2.61705
|
|
14
|
5,8,11,14-Eicosatetraynoic Acid
|
Compound
|
Inferred
|
Explain
|
1.79901
|
|
15
|
Autacoids
|
Compound
|
Inferred
|
Explain
|
0.89570
|
|
16
|
Linolenic Acids
|
Compound
|
Inferred
|
Explain
|
0.84331
|
|
17
|
Linoleic Acids
|
Compound
|
Inferred
|
Explain
|
0.57850
|
|
18
|
Eicosapentaenoic Acid
|
Compound
|
Inferred
|
Explain
|
0.54628
|
|
19
|
Diarrhea
|
Disease
|
Inferred
|
Explain
|
0.52520
|
|
20
|
Prostaglandin Endoperoxides
|
Compound
|
Inferred
|
Explain
|
0.36874
|
|
21
|
Prostaglandins I
|
Compound
|
Inferred
|
Explain
|
0.35617
|
|
22
|
Arachidonic Acid
|
Compound
|
Inferred
|
Explain
|
0.33719
|
|
23
|
Prostaglandins D
|
Compound
|
Inferred
|
Explain
|
0.32235
|
|
24
|
Prostaglandins F
|
Compound
|
Inferred
|
Explain
|
0.28940
|
|
25
|
Prostaglandins, Synthetic
|
Compound
|
Inferred
|
Explain
|
0.22686
|
|
26
|
Prostaglandins E
|
Compound
|
Inferred
|
Explain
|
0.22047
|
|
27
|
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
|
Compound
|
Inferred
|
Explain
|
0.19771
|
|
28
|
CYP2C8 gene
|
Gene
|
Inferred
|
Explain
|
0.18501
|
|
29
|
Neuroprostanes
|
Compound
|
Inferred
|
Explain
|
0.11460
|
|
30
|
Prostaglandin H2
|
Compound
|
Inferred
|
Explain
|
0.09086
|
|
31
|
Epoprostenol
|
Compound
|
Inferred
|
Explain
|
0.08721
|
|
32
|
Gefarnate
|
Compound
|
Inferred
|
Explain
|
0.08486
|
|
33
|
Prostaglandins H
|
Compound
|
Inferred
|
Explain
|
0.08331
|
|
34
|
Dengue Fever
|
Disease
|
Inferred
|
Explain
|
0.08219
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|
35
|
Fatty Acids, Omega-6
|
Compound
|
Inferred
|
Explain
|
0.08168
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|
36
|
Prostaglandin D2
|
Compound
|
Inferred
|
Explain
|
0.08057
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|
37
|
F2-Isoprostanes
|
Compound
|
Inferred
|
Explain
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0.06445
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|
38
|
6-Ketoprostaglandin F1 alpha
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Compound
|
Inferred
|
Explain
|
0.05734
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|
39
|
CES1 gene
|
Gene
|
Inferred
|
Explain
|
0.05653
|
|
40
|
Fatty Acids, Monounsaturated
|
Compound
|
Inferred
|
Explain
|
0.05286
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|
41
|
Leukotriene A4
|
Compound
|
Inferred
|
Explain
|
0.05025
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|
42
|
thromboxane-A synthase activity
|
Function
|
Inferred
|
Explain
|
0.04934
|
|
43
|
Linoleic Acids, Conjugated
|
Compound
|
Inferred
|
Explain
|
0.04915
|
|
44
|
SRS-A
|
Compound
|
Inferred
|
Explain
|
0.04540
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|
45
|
Omega-3 Fatty Acids
|
Compound
|
Inferred
|
Explain
|
0.04180
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|
46
|
Leukotriene B4
|
Compound
|
Inferred
|
Explain
|
0.03970
|
|
47
|
ALOX5 gene
|
Gene
|
Inferred
|
Explain
|
0.03914
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|
48
|
GSTA2 gene
|
Gene
|
Inferred
|
Explain
|
0.03652
|
|
49
|
Docosahexaenoic Acids
|
Compound
|
Inferred
|
Explain
|
0.03578
|
|
50
|
Toxic effect of carbon tetrachloride
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Other
|
Inferred
|
Explain
|
0.03449
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|
51
|
Asthma, Exercise-Induced
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Disease
|
Inferred
|
Explain
|
0.03367
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|
52
|
Allergic Conjunctivitis
|
Disease
|
Inferred
|
Explain
|
0.03317
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|
53
|
Peroxides
|
Compound
|
Inferred
|
Explain
|
0.03279
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|
54
|
PPARA gene
|
Gene
|
Inferred
|
Explain
|
0.03237
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|
55
|
Dinoprost
|
Compound
|
Inferred
|
Explain
|
0.03152
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|
56
|
prostanoid metabolic process
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Function
|
Inferred
|
Explain
|
0.03018
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|
57
|
Ionomycin
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Compound
|
Inferred
|
Explain
|
0.02975
|
|
58
|
prostaglandin biosynthetic process
|
Function
|
Inferred
|
Explain
|
0.02877
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|
59
|
Linoleic Acid
|
Compound
|
Inferred
|
Explain
|
0.02702
|
|
60
|
cellular chloride ion homeostasis
|
Function
|
Inferred
|
Explain
|
0.02617
|
|
61
|
Inflammation Mediators
|
Compound
|
Inferred
|
Explain
|
0.02122
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|
62
|
positive regulation of vasoconstriction
|
Function
|
Inferred
|
Explain
|
0.02119
|
|
63
|
IL4 gene
|
Gene
|
Inferred
|
Explain
|
0.01795
|
|
64
|
Rhinitis
|
Disease
|
Inferred
|
Explain
|
0.01500
|
|
65
|
Eosinophilia
|
Disease
|
Inferred
|
Explain
|
0.01344
|
|
66
|
Hematological Disease
|
Disease
|
Inferred
|
Explain
|
0.01316
|
|
67
|
CD40 gene
|
Gene
|
Inferred
|
Explain
|
0.01194
|
|
68
|
Arachidonic Acid Metabolism Pathway
|
Function
|
Inferred
|
Explain
|
0.01181
|
|
69
|
Terpenes
|
Compound
|
Inferred
|
Explain
|
0.01180
|
|
70
|
Fatty Acids
|
Compound
|
Inferred
|
Explain
|
0.01173
|
|
71
|
Alprostadil
|
Compound
|
Inferred
|
Explain
|
0.01133
|
|
72
|
gamma-Linolenic Acid
|
Compound
|
Inferred
|
Explain
|
0.01083
|
|
73
|
NR1H3 gene
|
Gene
|
Inferred
|
Explain
|
0.01046
|
|
74
|
Hemorrhage
|
Disease
|
Inferred
|
Explain
|
0.01002
|
|
75
|
leukotriene receptor activity
|
Function
|
Inferred
|
Explain
|
0.00968
|
|
76
|
leukotriene B4 receptor activity
|
Function
|
Inferred
|
Explain
|
0.00963
|
|
77
|
Prostaglandin Endoperoxides, Synthetic
|
Compound
|
Inferred
|
Explain
|
0.00888
|
|
78
|
PTGIS gene
|
Gene
|
Inferred
|
Explain
|
0.00825
|
|
79
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
Compound
|
Inferred
|
Explain
|
0.00798
|
|
80
|
IL12B gene
|
Gene
|
Inferred
|
Explain
|
0.00785
|
|
81
|
Prostaglandins E, Synthetic
|
Compound
|
Inferred
|
Explain
|
0.00731
|
|
82
|
alpha-Linolenic Acid
|
Compound
|
Inferred
|
Explain
|
0.00729
|
|
83
|
Kinins
|
Compound
|
Inferred
|
Explain
|
0.00722
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|
84
|
hormone biosynthetic process
|
Function
|
Inferred
|
Explain
|
0.00706
|
|
85
|
5,12-diHETE
|
Compound
|
Inferred
|
Explain
|
0.00675
|
|
86
|
Angiotensins
|
Compound
|
Inferred
|
Explain
|
0.00656
|
|
87
|
intramolecular oxidoreductase activity
|
Function
|
Inferred
|
Explain
|
0.00652
|
|
88
|
keratinocyte migration
|
Function
|
Inferred
|
Explain
|
0.00650
|
|
89
|
montelukast
|
Compound
|
Inferred
|
Explain
|
0.00622
|
|
90
|
Cavity of endoplasmic reticulum cistern
|
Component
|
Inferred
|
Explain
|
0.00582
|
|
91
|
zafirlukast
|
Compound
|
Inferred
|
Explain
|
0.00561
|
|
92
|
APOA1 gene
|
Gene
|
Inferred
|
Explain
|
0.00561
|
|
93
|
TNF gene
|
Gene
|
Inferred
|
Explain
|
0.00558
|
|
94
|
fatty acid biosynthetic process
|
Function
|
Inferred
|
Explain
|
0.00548
|
|
95
|
HSD11B2 gene
|
Gene
|
Inferred
|
Explain
|
0.00525
|
|
96
|
monooxygenase activity
|
Function
|
Inferred
|
Explain
|
0.00506
|
|
97
|
ALOX12 gene
|
Gene
|
Inferred
|
Explain
|
0.00486
|
|
98
|
Platelet Activating Factor
|
Compound
|
Inferred
|
Explain
|
0.00455
|
|
99
|
16,16-Dimethylprostaglandin E2
|
Compound
|
Inferred
|
Explain
|
0.00446
|
|
100
|
GSTM2 gene
|
Gene
|
Inferred
|
Explain
|
0.00437
|
|