Sulfasalazine

Compound • C0036078

Definition

A synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug, antiinflammatory Sulfasalazine acts locally in the intestine through its active metabolites, sulfamide 5-aminosalicylic acid and sal

Synonyms

Sulfasalazine • Sulphasalazine • Salazosulfapyridine • Salicylazosulfapyridine • Benzoic acid, 2-hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)- • 2-Hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic Acid • Sulfasalazine [Chemical/Ingredient]

Linked items?Related concepts, ordered by their global importance in the network.

RELA gene    IL8 gene    IL1B gene    Malignant neoplasm of breast    Liver Cirrhosis, Experimental    TRAF1 gene    Rheumatoid Arthritis    NAT2 gene    Ulcerative Colitis    SLC46A1 gene    Inflammatory Bowel Diseases    Sulfonamides    Behcet Syndrome   

Related concepts

# Concept name Type Relation Support Score
1 Behcet Syndrome Disease Known Explain 9.26733
2 Inflammatory Bowel Diseases Disease Known Explain 6.13239
3 Sulfonamides Compound Known Explain 6.12327
4 SLC46A1 gene Gene Known Explain 5.25826
5 Ulcerative Colitis Disease Known Explain 3.96102
6 TRAF1 gene Gene Known Explain 2.43827
7 Rheumatoid Arthritis Disease Known Explain 2.25079
8 NAT2 gene Gene Known Explain 2.04695
9 Liver Cirrhosis, Experimental Disease Known Explain 0.93936
10 Malignant neoplasm of breast Disease Known Explain 0.57992
11 IL1B gene Gene Known Explain 0.57596
12 IL8 gene Gene Known Explain 0.53628
13 RELA gene Gene Known Explain 0.49271
14 Azathioprine Compound Inferred Explain 0.07105
15 Anterior uveitis Disease Inferred Explain 0.05973
16 DEFB4A gene Gene Inferred Explain 0.04351
17 Metolazone Compound Inferred Explain 0.04127
18 Clopamide Compound Inferred Explain 0.03816
19 Indapamide Compound Inferred Explain 0.03706
20 Dichlorphenamide Compound Inferred Explain 0.03504
21 Colchicine Compound Inferred Explain 0.03477
22 Sulfanilamides Compound Inferred Explain 0.03402
23 Chlorthalidone Compound Inferred Explain 0.03313
24 Skin Diseases, Vascular Disease Inferred Explain 0.03139
25 Bumetanide Compound Inferred Explain 0.03100
26 Benzolamide Compound Inferred Explain 0.03038
27 Sulfones Compound Inferred Explain 0.02926
28 Ethoxzolamide Compound Inferred Explain 0.02825
29 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Compound Inferred Explain 0.02573
30 Benzothiadiazines Compound Inferred Explain 0.02399
31 Probenecid Compound Inferred Explain 0.02379
32 Vasculitis Disease Inferred Explain 0.02239
33 Trinitrobenzenesulfonic Acid Compound Inferred Explain 0.02108
34 NAT1 gene Gene Inferred Explain 0.01953
35 Sumatriptan Compound Inferred Explain 0.01936
36 IRF5 gene Gene Inferred Explain 0.01548
37 Z 103 Compound Inferred Explain 0.01530
38 Mouth Diseases Disease Inferred Explain 0.01482
39 Amides Compound Inferred Explain 0.01431
40 Quinazolinones Compound Inferred Explain 0.01421
41 Dextran Sulfate Compound Inferred Explain 0.01337
42 IL10 gene Gene Inferred Explain 0.01160
43 Colitis Disease Inferred Explain 0.01083
44 Rutin Compound Inferred Explain 0.01032
45 DEFA5 gene Gene Inferred Explain 0.01028
46 5-Aminosalicylate Compound Inferred Explain 0.00850
47 CA3 gene Gene Inferred Explain 0.00816
48 Crohn Disease Disease Inferred Explain 0.00781
49 Thionucleosides Compound Inferred Explain 0.00706
50 5,12-diHETE Compound Inferred Explain 0.00668
51 Gastroenteritis Disease Inferred Explain 0.00666
52 IL23R gene Gene Inferred Explain 0.00641
53 mercaptopurine Compound Inferred Explain 0.00614
54 ATG16L1 gene Gene Inferred Explain 0.00583
55 Benzophenones Compound Inferred Explain 0.00579
56 folic acid transporter activity Function Inferred Explain 0.00568
57 SLC22A4 gene Gene Inferred Explain 0.00559
58 Sulfobromophthalein Compound Inferred Explain 0.00555
59 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid Compound Inferred Explain 0.00515
60 Phthalimides Compound Inferred Explain 0.00508
61 Malabsorption Syndrome Disease Inferred Explain 0.00503
62 Intestinal Diseases Disease Inferred Explain 0.00491
63 5-methyltetrahydrofolate Compound Inferred Explain 0.00490
64 IL6 gene Gene Inferred Explain 0.00489
65 DLG5 gene Gene Inferred Explain 0.00488
66 heme transporter activity Function Inferred Explain 0.00476
67 HLA-B gene Gene Inferred Explain 0.00470
68 SLC11A1 gene Gene Inferred Explain 0.00466
69 Sulfamethazine Compound Inferred Explain 0.00463
70 folic acid transport Function Inferred Explain 0.00463
71 Indoles Compound Inferred Explain 0.00461
72 Sulfamethoxazole Compound Inferred Explain 0.00452
73 Pancreatitis Disease Inferred Explain 0.00446
74 heme transport Function Inferred Explain 0.00445
75 TNF gene Gene Inferred Explain 0.00424
76 Sulfadiazine Compound Inferred Explain 0.00418
77 VNN1 gene Gene Inferred Explain 0.00405
78 Regional enteritis Disease Inferred Explain 0.00400
79 Heme Compound Inferred Explain 0.00393
80 folic acid metabolism Function Inferred Explain 0.00349
81 CA2 gene Gene Inferred Explain 0.00343
82 Piperidines Compound Inferred Explain 0.00340
83 zileuton Compound Inferred Explain 0.00340
84 Deferoxamine Compound Inferred Explain 0.00330
85 FCGR2A gene Gene Inferred Explain 0.00327
86 Iridocyclitis Disease Inferred Explain 0.00305
87 Iritis Disease Inferred Explain 0.00305
88 Curcumin Compound Inferred Explain 0.00293
89 folic acid binding Function Inferred Explain 0.00291
90 Iris Diseases Disease Inferred Explain 0.00278
91 PTGS2 gene Gene Inferred Explain 0.00261
92 KEGG:hsa04977 Pathway Inferred Explain 0.00258
93 ABCB1 gene Gene Inferred Explain 0.00252
94 Dapsone Compound Inferred Explain 0.00247
95 PRDM1 gene Gene Inferred Explain 0.00243
96 KIF21B gene Gene Inferred Explain 0.00243
97 CA1 gene Gene Inferred Explain 0.00242
98 MIRLET7F1 gene Gene Inferred Explain 0.00239
99 Peroxynitrite Compound Inferred Explain 0.00237
100 PSMG1 gene Gene Inferred Explain 0.00236