Furosemide

Compound • C0016860

Definition

An anthranilic derivative and loop diuretic with antihypertensive effect. Furosemide blocks the Na-K-Cl cotransporter (NKCC) in the luminal membrane of the thick ascending limb of the loop of Henle in the kidney, by binding to the Cl-binding site located

Synonyms

Furosemide • Frusemid • Fursemide • FRS • Benzoic acid, 5-(aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)- • Frusemide • Furosemide [Chemical/Ingredient]

Linked items?Related concepts, ordered by their global importance in the network.

TNF gene    IL6 gene    ALB gene    UGT1A1 gene    IL10 gene    Malignant neoplasm of stomach    UGT1A7 gene    UGT1A8 gene    ABCC2 gene    UGT1A10 gene    EGF gene    UGT1A3 gene    Kidney Diseases    ABCC3 gene    Edema    SLC22A7 gene    Heart failure    Reperfusion Injury    REN gene    hearing impairment   

Related concepts

# Concept name Type Relation Support Score
1 Hyperparathyroidism, Secondary Disease Known Explain 3.12190
2 Bedwetting Disease Known Explain 2.53799
3 Hypotension, Orthostatic Disease Known Explain 2.37532
4 Hypoproteinemia Disease Known Explain 2.23501
5 Nephrocalcinosis Disease Known Explain 2.05614
6 Hypertension induced by pregnancy Disease Known Explain 1.96895
7 Polyuria Disease Known Explain 1.92798
8 Hypercalcemia Disease Known Explain 1.86329
9 Primary hypomagnesemia (disorder) Disease Known Explain 1.69725
10 Dyspnea Disease Known Explain 1.68126
11 Sulfanilamides Compound Known Explain 1.45126
12 Hypotension Disease Known Explain 1.42171
13 Hypercalciuria Disease Known Explain 1.38864
14 Respiratory Distress Syndrome, Adult Disease Known Explain 1.37166
15 hearing impairment Disease Known Explain 0.72605
16 Heart failure Disease Known Explain 0.65322
17 Reperfusion Injury Other Known Explain 0.65320
18 REN gene Gene Known Explain 0.60623
19 SLC22A7 gene Gene Known Explain 0.49069
20 ABCC3 gene Gene Known Explain 0.45680
21 NPS R-467 Compound Inferred Explain 0.45548
22 Edema Disease Known Explain 0.37179
23 Kidney Diseases Disease Known Explain 0.33989
24 Renal Osteodystrophy Disease Inferred Explain 0.32463
25 UGT1A10 gene Gene Known Explain 0.29413
26 UGT1A3 gene Gene Known Explain 0.28640
27 UGT1A8 gene Gene Known Explain 0.27133
28 UGT1A7 gene Gene Known Explain 0.26815
29 EGF gene Gene Known Explain 0.26694
30 Hyperparathyroidism Disease Inferred Explain 0.20754
31 ABCC2 gene Gene Known Explain 0.20490
32 Familial benign hypercalcemia Disease Inferred Explain 0.19634
33 Hydrochlorothiazide Compound Inferred Explain 0.18663
34 Malignant neoplasm of stomach Disease Known Explain 0.18181
35 UGT1A1 gene Gene Known Explain 0.17719
36 IL10 gene Gene Known Explain 0.16036
37 Lisinopril Compound Inferred Explain 0.14700
38 Blue diaper syndrome Disease Inferred Explain 0.11465
39 ALB gene Gene Known Explain 0.11194
40 Orthostatic intolerance Disease Inferred Explain 0.10634
41 HYPOCALCIURIC HYPERCALCEMIA, FAMILIAL, TYPE III Disease Inferred Explain 0.10336
42 HYPOCALCIURIC HYPERCALCEMIA, FAMILIAL, TYPE II (disorder) Disease Inferred Explain 0.10336
43 IL6 gene Gene Known Explain 0.09801
44 Enuresis Disease Inferred Explain 0.08196
45 TNF gene Gene Known Explain 0.07528
46 Dyspnea, Paroxysmal Disease Inferred Explain 0.06784
47 CASR gene Gene Inferred Explain 0.06714
48 Hypoalbuminemia Disease Inferred Explain 0.06666
49 Urological Manifestations Disease Inferred Explain 0.06491
50 Diazoxide Compound Inferred Explain 0.06457
51 HYPOPROTEINEMIA, HYPERCATABOLIC Disease Inferred Explain 0.05916
52 PROTEINURIA, LOW MOLECULAR WEIGHT, WITH HYPERCALCIURIA AND NEPHROCALCINOSIS Disease Inferred Explain 0.05622
53 HYPOMAGNESEMIA 5, RENAL, WITH OCULAR INVOLVEMENT Disease Inferred Explain 0.05485
54 Urination Disorders Disease Inferred Explain 0.04575
55 Clonidine Compound Inferred Explain 0.04156
56 Monocrotophos Compound Inferred Explain 0.03844
57 Pre-Eclampsia Disease Inferred Explain 0.03719
58 Trittico Compound Inferred Explain 0.03581
59 Risperidone Compound Inferred Explain 0.03416
60 Mirex Compound Inferred Explain 0.03344
61 Respiration Disorders Disease Inferred Explain 0.03183
62 Calcium Metabolism Disorders Disease Inferred Explain 0.03169
63 Rickets Disease Inferred Explain 0.03039
64 Chlorothiazide Compound Inferred Explain 0.02669
65 Blood Protein Disorders Disease Inferred Explain 0.02597
66 Bone Diseases, Metabolic Disease Inferred Explain 0.02568
67 HYPERPHOSPHATEMIA, POLYURIA, AND SEIZURES Disease Inferred Explain 0.02522
68 HYPOURICEMIA, HYPERCALCINURIA, AND DECREASED BONE DENSITY Disease Inferred Explain 0.02471
69 SLC34A1 gene Gene Inferred Explain 0.02450
70 HYPERPARATHYROIDISM, NEONATAL SELF-LIMITED PRIMARY, WITH HYPERCALCIURIA Disease Inferred Explain 0.02427
71 cypermethrin Compound Inferred Explain 0.02400
72 Hypertensive disease Disease Inferred Explain 0.02353
73 Diazinon Compound Inferred Explain 0.02255
74 Water-Electrolyte Imbalance Disease Inferred Explain 0.02193
75 3-(2,4-dimethylpyrrol-5-yl)methylidene-indolin-2-one Compound Inferred Explain 0.02186
76 Enamel-renal syndrome Disease Inferred Explain 0.02184
77 HYPOMAGNESEMIA Disease Inferred Explain 0.02137
78 Signs and Symptoms, Respiratory Disease Inferred Explain 0.02119
79 Dichlorodiphenyl Dichloroethylene Compound Inferred Explain 0.01834
80 Dietary Magnesium Compound Inferred Explain 0.01809
81 Proteinuria Disease Inferred Explain 0.01778
82 Calcinosis Disease Inferred Explain 0.01747
83 Benzothiadiazines Compound Inferred Explain 0.01625
84 Tacrolimus Compound Inferred Explain 0.01606
85 Sulfapyridine Compound Inferred Explain 0.01586
86 RENAL TUBULAR ACIDOSIS, DISTAL, WITH NEPHROCALCINOSIS, SHORT STATURE, MENTAL RETARDATION, AND DISTINCTIVE FACIES Disease Inferred Explain 0.01569
87 Sulfaguanidine Compound Inferred Explain 0.01554
88 Familial idiopathic hypercalciuria Other Inferred Explain 0.01543
89 ATAXIA, EARLY-ONSET, WITH OCULOMOTOR APRAXIA AND HYPOALBUMINEMIA Disease Inferred Explain 0.01540
90 Sulfathiazoles Compound Inferred Explain 0.01503
91 Bartter syndrome, antenatal , type 2 Disease Inferred Explain 0.01381
92 Sulfamethazine Compound Inferred Explain 0.01353
93 Bartter syndrome, antenatal type 1 Disease Inferred Explain 0.01349
94 Sulfamethoxazole Compound Inferred Explain 0.01317
95 alpha-Endosulfan Compound Inferred Explain 0.01316
96 autosomal recessive hypophosphatemic bone disease Disease Inferred Explain 0.01295
97 DDT (Insecticide) Compound Inferred Explain 0.01294
98 Pregnancy Complications Disease Inferred Explain 0.01283
99 Sulfaphenazole Compound Inferred Explain 0.01264
100 Sulfadiazine Compound Inferred Explain 0.01207