Factor XIII Deficiency

Disease • C0015530

Definition

A deficiency of blood coagulation FACTOR XIII or fibrin stabilizing factor (FSF) that prevents blood clot formation and results in a clinical hemorrhagic diathesis.

Synonyms

Factor XIII Deficiency • Deficiency, factor XIII • Deficiencies, Factor XIII • Factor XIII Deficiencies • Deficiency of factor XIII • FIBRIN STABILIZING FACTOR DEFICIENCY, CONGENITAL • LAKI-LORAND FACTOR DEFICIENCY, CONGENITAL • FACTOR XIII DEFICIENCY, CONGENITAL • FIBRINASE DEFICIENCY, CONGENITAL • Deficiency, Laki-Lorand factor • DEFIC FACTOR XIII • FACTOR XIII DEFIC • Factor XIII Deficiency [Disease/Finding]

Linked items?Related concepts, ordered by their global importance in the network.

F13A1 gene    Hemorrhagic Disorders    Blood Coagulation Disorders, Inherited    Coagulation Protein Disorders    F13B gene   

Related concepts

# Concept name Type Relation Support Score
1 F13B gene Gene Known Explain 95.36274
2 Coagulation Protein Disorders Disease Known Explain 80.13237
3 Blood Coagulation Disorders, Inherited Disease Known Explain 60.02542
4 Hemorrhagic Disorders Disease Known Explain 54.41915
5 F13A1 gene Gene Known Explain 45.61894
6 Hypoprothrombinemias Disease Inferred Explain 2.43543
7 Factor VII Deficiency Disease Inferred Explain 2.43255
8 Factor V Deficiency Disease Inferred Explain 2.42362
9 Factor X Deficiency Disease Inferred Explain 2.40462
10 Factor XI Deficiency Disease Inferred Explain 2.39455
11 Factor XII Deficiency Disease Inferred Explain 2.35862
12 Afibrinogenemia Disease Inferred Explain 2.16322
13 Hemophilia B Disease Inferred Explain 2.15888
14 Hemophilia A Disease Inferred Explain 1.89782
15 von Willebrand Disease Disease Inferred Explain 1.66926
16 Activated Protein C Resistance Disease Inferred Explain 1.51993
17 Blood Coagulation Disorders Disease Inferred Explain 0.91947
18 Thrombasthenia Disease Inferred Explain 0.70740
19 Wiskott-Aldrich Syndrome Disease Inferred Explain 0.64541
20 Hermanski-Pudlak Syndrome Disease Inferred Explain 0.60400
21 Bernard-Soulier Syndrome Disease Inferred Explain 0.56137
22 Blood Platelet Disorders Disease Inferred Explain 0.46673
23 Platelet Storage Pool Deficiency Disease Inferred Explain 0.35247
24 Gray Platelet Syndrome Disease Inferred Explain 0.29918
25 Disseminated Intravascular Coagulation Disease Inferred Explain 0.27954
26 Thrombophilia Disease Inferred Explain 0.24739
27 Antithrombin III Deficiency Disease Inferred Explain 0.24386
28 Thrombocythemia, Essential Disease Inferred Explain 0.23980
29 Protein C Deficiency Disease Inferred Explain 0.22966
30 Vitamin K Deficiency Disease Inferred Explain 0.22734
31 F7 gene Gene Inferred Explain 0.18051
32 Waterhouse-Friderichsen Syndrome Disease Inferred Explain 0.17514
33 FGG gene Gene Inferred Explain 0.16193
34 Purpura, Thrombocytopenic, Idiopathic Disease Inferred Explain 0.15274
35 F9 gene Gene Inferred Explain 0.13216
36 FGA gene Gene Inferred Explain 0.12958
37 Hereditary factor I deficiency disease Disease Inferred Explain 0.12928
38 F11 gene Gene Inferred Explain 0.12741
39 Complement and coagulation cascades - Homo sapiens (human) Pathway Inferred Explain 0.11949
40 Hematological Disease Disease Inferred Explain 0.11399
41 F5 gene Gene Inferred Explain 0.09592
42 Genetic Diseases, X-Linked Disease Inferred Explain 0.09125
43 Sushi/SCR/CCP Domain Inferred Explain 0.09006
44 Complement control module Domain Inferred Explain 0.08443
45 Vascular Hemostatic Disorders Disease Inferred Explain 0.08234
46 F12 gene Gene Inferred Explain 0.07541
47 F2 gene Gene Inferred Explain 0.07396
48 FGB gene Gene Inferred Explain 0.07126
49 F10 gene Gene Inferred Explain 0.06707
50 CFI gene Gene Inferred Explain 0.05887
51 Alkylamine Compound Inferred Explain 0.04391
52 Protein glutamine Compound Inferred Explain 0.04391
53 Protein N5-alkylglutamine Compound Inferred Explain 0.04391
54 P2RX1 gene Gene Inferred Explain 0.04336
55 Iodoacetamide Compound Inferred Explain 0.04179
56 Lymphopenia Disease Inferred Explain 0.04126
57 Blood Protein Disorders Disease Inferred Explain 0.04111
58 protein-glutamine gamma-glutamyltransferase activity Function Inferred Explain 0.03581
59 Genetic Diseases, Inborn Disease Inferred Explain 0.03183
60 PROC gene Gene Inferred Explain 0.03178
61 Malnutrition Disease Inferred Explain 0.03156
62 Blood coagulation Function Inferred Explain 0.02914
63 MTHFR gene Gene Inferred Explain 0.02886
64 GIANT PLATELET SYNDROME WITH THROMBOCYTOPENIA Disease Inferred Explain 0.02865
65 Protein S Deficiency Disease Inferred Explain 0.02781
66 VWF gene Gene Inferred Explain 0.02687
67 HEMOPHILIA A WITH VASCULAR ABNORMALITY Disease Inferred Explain 0.02671
68 Thrombocytosis Disease Inferred Explain 0.02540
69 Purpura Disease Inferred Explain 0.02214
70 SERPINF2 gene Gene Inferred Explain 0.02138
71 Blood Platelets Other Inferred Explain 0.02131
72 von Willebrand Disease, Type 3 Disease Inferred Explain 0.02106
73 VON WILLEBRAND DISEASE, X-LINKED FORM Disease Inferred Explain 0.02106
74 Von Willebrand disease, platelet type Disease Inferred Explain 0.02062
75 von Willebrand Disease, Recessive Form Disease Inferred Explain 0.02022
76 GP1BA gene Gene Inferred Explain 0.01994
77 GP9 gene Gene Inferred Explain 0.01901
78 platelet alpha granule lumen Component Inferred Explain 0.01855
79 Immunologic Deficiency Syndromes Disease Inferred Explain 0.01825
80 GP1BB gene Gene Inferred Explain 0.01509
81 F8 gene Gene Inferred Explain 0.01496
82 Arbutin Compound Inferred Explain 0.01414
83 ITGA2B gene Gene Inferred Explain 0.01362
84 Vitamin D Compound Inferred Explain 0.01361
85 platelet degranulation Function Inferred Explain 0.01326
86 propylene dichloride Compound Inferred Explain 0.01195
87 Warfarin Compound Inferred Explain 0.01086
88 Thrombocytopenia Disease Inferred Explain 0.01046
89 Ammonia Compound Inferred Explain 0.01019
90 Ethionine Compound Inferred Explain 0.00929
91 PLEK gene Gene Inferred Explain 0.00884
92 Estradiol Compound Inferred Explain 0.00798
93 Ecchymosis Disease Inferred Explain 0.00796
94 Avitaminosis Disease Inferred Explain 0.00762
95 extracellular region Component Inferred Explain 0.00745
96 Platelet Activation Function Inferred Explain 0.00743
97 Benzbromarone Compound Inferred Explain 0.00734
98 WAS gene Gene Inferred Explain 0.00731
99 Thrombocytopenic purpura Disease Inferred Explain 0.00716
100 Propylthiouracil Compound Inferred Explain 0.00707