Factor XII Deficiency

Disease • C0015526

Definition

A rare autosomal recessive inherited bleeding disorder caused by deficiency of coagulation factor XII. It may be asymptomatic or manifest with bleeding.

Synonyms

Factor XII Deficiency • Deficiency, factor XII • Deficiencies, Factor XII • Factor XII Deficiencies • Hageman Trait • Trait, Hageman • Hageman Factor Deficiency • Deficiency, Hageman Factor • Factor Deficiency, Hageman • Deficiency, Hageman • DEFIC FACTOR XII • FACTOR XII DEFIC • F12 DEFICIENCY • HAF DEFICIENCY • Factor XII Deficiency [Disease/Finding] • Coagulation Factor 12 Deficiency • Factor 12 Deficiency • Deficiencies, Factor 12 • Factor 12 Deficiencies • Deficiency, Factor 12

Linked items?Related concepts, ordered by their global importance in the network.

F12 gene    Hemorrhagic Disorders    Blood Coagulation Disorders, Inherited    Coagulation Protein Disorders   

Related concepts

# Concept name Type Relation Support Score
1 Coagulation Protein Disorders Disease Known Explain 120.82880
2 Blood Coagulation Disorders, Inherited Disease Known Explain 90.43835
3 Hemorrhagic Disorders Disease Known Explain 81.99938
4 F12 gene Gene Known Explain 49.89211
5 Hypoprothrombinemias Disease Inferred Explain 3.64132
6 Factor VII Deficiency Disease Inferred Explain 3.64058
7 Factor V Deficiency Disease Inferred Explain 3.62559
8 Factor X Deficiency Disease Inferred Explain 3.59871
9 Factor XI Deficiency Disease Inferred Explain 3.58799
10 Factor XIII Deficiency Disease Inferred Explain 3.35623
11 Hemophilia B Disease Inferred Explain 3.23014
12 Afibrinogenemia Disease Inferred Explain 3.21846
13 Hemophilia A Disease Inferred Explain 2.83732
14 von Willebrand Disease Disease Inferred Explain 2.49306
15 Activated Protein C Resistance Disease Inferred Explain 2.27331
16 Blood Coagulation Disorders Disease Inferred Explain 1.36528
17 Thrombasthenia Disease Inferred Explain 1.05789
18 Wiskott-Aldrich Syndrome Disease Inferred Explain 0.96465
19 Hermanski-Pudlak Syndrome Disease Inferred Explain 0.90148
20 Bernard-Soulier Syndrome Disease Inferred Explain 0.84381
21 Blood Platelet Disorders Disease Inferred Explain 0.69441
22 Platelet Storage Pool Deficiency Disease Inferred Explain 0.52549
23 Gray Platelet Syndrome Disease Inferred Explain 0.44695
24 Disseminated Intravascular Coagulation Disease Inferred Explain 0.41636
25 Thrombophilia Disease Inferred Explain 0.36437
26 Antithrombin III Deficiency Disease Inferred Explain 0.36331
27 Thrombocythemia, Essential Disease Inferred Explain 0.35734
28 Protein C Deficiency Disease Inferred Explain 0.34213
29 Vitamin K Deficiency Disease Inferred Explain 0.33911
30 F7 gene Gene Inferred Explain 0.27308
31 Waterhouse-Friderichsen Syndrome Disease Inferred Explain 0.26139
32 Purpura, Thrombocytopenic, Idiopathic Disease Inferred Explain 0.22809
33 F11 gene Gene Inferred Explain 0.20729
34 F9 gene Gene Inferred Explain 0.20002
35 F13B gene Gene Inferred Explain 0.19933
36 Hereditary factor I deficiency disease Disease Inferred Explain 0.18873
37 Hematological Disease Disease Inferred Explain 0.16921
38 F5 gene Gene Inferred Explain 0.13642
39 Genetic Diseases, X-Linked Disease Inferred Explain 0.13581
40 Vascular Hemostatic Disorders Disease Inferred Explain 0.12265
41 F10 gene Gene Inferred Explain 0.10083
42 F13A1 gene Gene Inferred Explain 0.10032
43 FGA gene Gene Inferred Explain 0.09911
44 plasma kallikrein-kinin cascade Disease Inferred Explain 0.09535
45 FGB gene Gene Inferred Explain 0.09288
46 CFI gene Gene Inferred Explain 0.08509
47 GP1BA gene Gene Inferred Explain 0.07789
48 Hereditary Angioedema Type III Disease Inferred Explain 0.07433
49 F2 gene Gene Inferred Explain 0.07240
50 P2RX1 gene Gene Inferred Explain 0.06413
51 Lymphopenia Disease Inferred Explain 0.06142
52 Blood Protein Disorders Disease Inferred Explain 0.06067
53 Malnutrition Disease Inferred Explain 0.05250
54 Genetic Diseases, Inborn Disease Inferred Explain 0.05204
55 blood coagulation, intrinsic pathway Function Inferred Explain 0.04861
56 PROC gene Gene Inferred Explain 0.04390
57 Factor XII activation Function Inferred Explain 0.04298
58 positive regulation of plasminogen activation Function Inferred Explain 0.04290
59 GIANT PLATELET SYNDROME WITH THROMBOCYTOPENIA Disease Inferred Explain 0.04288
60 MTHFR gene Gene Inferred Explain 0.04272
61 positive regulation of fibrinolysis Function Inferred Explain 0.04215
62 Protein S Deficiency Disease Inferred Explain 0.04100
63 zymogen activation Function Inferred Explain 0.04014
64 HEMOPHILIA A WITH VASCULAR ABNORMALITY Disease Inferred Explain 0.03949
65 VWF gene Gene Inferred Explain 0.03945
66 Thrombocytosis Disease Inferred Explain 0.03765
67 positive regulation of blood coagulation Function Inferred Explain 0.03681
68 protein autoprocessing Function Inferred Explain 0.03564
69 response to misfolded protein Function Inferred Explain 0.03525
70 misfolded protein binding Function Inferred Explain 0.03349
71 Purpura Disease Inferred Explain 0.03259
72 GP9 gene Gene Inferred Explain 0.03240
73 Blood Platelets Other Inferred Explain 0.03191
74 Von Willebrand disease, platelet type Disease Inferred Explain 0.03159
75 von Willebrand Disease, Type 3 Disease Inferred Explain 0.03117
76 VON WILLEBRAND DISEASE, X-LINKED FORM Disease Inferred Explain 0.03117
77 kinin cascade Disease Inferred Explain 0.03031
78 von Willebrand Disease, Recessive Form Disease Inferred Explain 0.02983
79 KLKB1 gene Gene Inferred Explain 0.02924
80 Immunologic Deficiency Syndromes Disease Inferred Explain 0.02697
81 GP1BB gene Gene Inferred Explain 0.02519
82 Angioedemas, Hereditary Disease Inferred Explain 0.02309
83 Complement and coagulation cascades - Homo sapiens (human) Pathway Inferred Explain 0.02279
84 F8 gene Gene Inferred Explain 0.02138
85 protein maturation by peptide bond cleavage Function Inferred Explain 0.02105
86 ITGA2B gene Gene Inferred Explain 0.01894
87 APOH gene Gene Inferred Explain 0.01774
88 propylene dichloride Compound Inferred Explain 0.01762
89 Warfarin Compound Inferred Explain 0.01554
90 Thrombocytopenia Disease Inferred Explain 0.01536
91 Angioneurotic edema, NEC in ICD9CM_2011 Disease Inferred Explain 0.01456
92 MMP12 gene Gene Inferred Explain 0.01438
93 Ethionine Compound Inferred Explain 0.01374
94 CD93 gene Gene Inferred Explain 0.01289
95 Ecchymosis Disease Inferred Explain 0.01175
96 Avitaminosis Disease Inferred Explain 0.01113
97 Benzbromarone Compound Inferred Explain 0.01087
98 MMP13 gene Gene Inferred Explain 0.01061
99 Thrombocytopenic purpura Disease Inferred Explain 0.01052
100 WAS gene Gene Inferred Explain 0.01046