Epirubicin

Compound • C0014582

Definition

A 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also prod

Synonyms

Epirubicin • 4'-Epiadriamycin • 4' Epiadriamycin • 4''-Epiadriamycin • 4'-Epidoxorubicin • 4' Epidoxorubicin • 4''-Epidoxorubicin • 4'-Epi-DXR • 4' Epi DXR • 4''-Epi-DXR • EPI • 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)- • 4'-epi DX • 4'-epi-DX • epi-ADR • 3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside • (8S-cis)-10-[(-Amino-2,3,6-trideoxy-alpha-L-arabino-hexpyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxacetyl)-1-methoxy-5,12-naphthacenedione • Epi DX • Pidorubicin • (8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione • Epidoxorubicin • 4'-Epi-Adriamycin • 4' Epi Adriamycin • 4''-Epi-Adriamycin • 4'-Epi-Doxorubicin • 4' Epi Doxorubicin • 4''-Epi-Doxorubicin • EPIADRIAMYCIN 04 • EPIDOXORUBICIN 04 • Epirubicin [Chemical/Ingredient]

Linked items?Related concepts, ordered by their global importance in the network.

Doxorubicin    EGFR gene    BCL2 gene    CASP3 gene    Malignant neoplasm of breast    ERBB2 gene    ABCB1 gene    BIRC5 gene    melanoma    ERBB3 gene    ABCC1 gene    TOP2A gene    SOD2 gene    ABCG2 gene    DPYD gene    TYMP gene    S100P gene    Hodgkin Disease    FKBPL gene   

Related concepts

# Concept name Type Relation Support Score
1 FKBPL gene Gene Known Explain 3.95039
2 Hodgkin Disease Disease Known Explain 1.90157
3 S100P gene Gene Known Explain 1.75639
4 TYMP gene Gene Known Explain 1.18097
5 DPYD gene Gene Known Explain 0.96104
6 ABCG2 gene Gene Known Explain 0.81087
7 SOD2 gene Gene Known Explain 0.72987
8 TOP2A gene Gene Known Explain 0.67340
9 ERBB3 gene Gene Known Explain 0.63671
10 ABCC1 gene Gene Known Explain 0.60605
11 BIRC5 gene Gene Known Explain 0.49585
12 ABCB1 gene Gene Known Explain 0.46185
13 melanoma Disease Known Explain 0.43161
14 ERBB2 gene Gene Known Explain 0.35950
15 Malignant neoplasm of breast Disease Known Explain 0.30144
16 EGFR gene Gene Known Explain 0.20894
17 CASP3 gene Gene Known Explain 0.20541
18 Doxorubicin Compound Known Explain 0.19108
19 BCL2 gene Gene Known Explain 0.18257
20 Lomustine Compound Inferred Explain 0.01216
21 MIR135A1 gene Gene Inferred Explain 0.01159
22 EBVP protocol Other Inferred Explain 0.01063
23 bleomycin/doxorubicin/vinblastine protocol Other Inferred Explain 0.01063
24 BEACOPP protocol Other Inferred Explain 0.01063
25 PVT1 gene Gene Inferred Explain 0.00996
26 Prednimustine Compound Inferred Explain 0.00982
27 aranoza Compound Inferred Explain 0.00958
28 KLHDC8B gene Gene Inferred Explain 0.00955
29 MIR374A gene Gene Inferred Explain 0.00938
30 MIR186 gene Gene Inferred Explain 0.00865
31 Procarbazine Compound Inferred Explain 0.00865
32 Cyclophosphamide Compound Inferred Explain 0.00772
33 FSHB gene Gene Inferred Explain 0.00679
34 MOPP protocol Other Inferred Explain 0.00679
35 ABVD protocol Other Inferred Explain 0.00561
36 MIR200A gene Gene Inferred Explain 0.00561
37 MIR18A gene Gene Inferred Explain 0.00552
38 ABCC2 gene Gene Inferred Explain 0.00542
39 MIR30B gene Gene Inferred Explain 0.00534
40 MIR140 gene Gene Inferred Explain 0.00494
41 MIR196A1 gene Gene Inferred Explain 0.00466
42 NSC 628503 Compound Inferred Explain 0.00449
43 Dacarbazine Compound Inferred Explain 0.00434
44 Vincristine Compound Inferred Explain 0.00421
45 MIR20A gene Gene Inferred Explain 0.00416
46 Nitrogen Mustard Compounds Compound Inferred Explain 0.00406
47 Cytarabine Compound Inferred Explain 0.00400
48 Etoposide Compound Inferred Explain 0.00375
49 MIR92A1 gene Gene Inferred Explain 0.00374
50 taxane Compound Inferred Explain 0.00367
51 2-pyrrolino-DOX Compound Inferred Explain 0.00367
52 tectochrysin Compound Inferred Explain 0.00367
53 6-prenylchrysin Compound Inferred Explain 0.00367
54 Chlorambucil Compound Inferred Explain 0.00366
55 Bleomycin A2 Compound Inferred Explain 0.00361
56 AN 215 Compound Inferred Explain 0.00360
57 Fluorouracil Compound Inferred Explain 0.00355
58 Prednisone Compound Inferred Explain 0.00338
59 SDZ PSC 833 Compound Inferred Explain 0.00336
60 Vinblastine Compound Inferred Explain 0.00331
61 MIRLET7A1 gene Gene Inferred Explain 0.00330
62 TNFRSF8 gene Gene Inferred Explain 0.00330
63 Ifosfamide Compound Inferred Explain 0.00329
64 Cisplatin Compound Inferred Explain 0.00328
65 Thymine Compound Inferred Explain 0.00306
66 2-pyrrolino-DOX-14-O-glt-RC-121 Compound Inferred Explain 0.00302
67 CSF3 gene Gene Inferred Explain 0.00296
68 Lymphoma Disease Inferred Explain 0.00290
69 artesunate Compound Inferred Explain 0.00290
70 FK506 binding Function Inferred Explain 0.00288
71 7-epi-Taxol Compound Inferred Explain 0.00283
72 Uracil Compound Inferred Explain 0.00275
73 IFNA2 gene Gene Inferred Explain 0.00274
74 FEC protocol Other Inferred Explain 0.00274
75 Cyclosporine Compound Inferred Explain 0.00273
76 Protein Binding Function Inferred Explain 0.00265
77 Cyclosporins Compound Inferred Explain 0.00263
78 TP53 gene Gene Inferred Explain 0.00251
79 response to radiation Function Inferred Explain 0.00245
80 Cell Nucleus Component Inferred Explain 0.00242
81 CYP3A4 gene Gene Inferred Explain 0.00240
82 Estradiol Compound Inferred Explain 0.00234
83 GATA3 gene Gene Inferred Explain 0.00231
84 sodium arsenite Compound Inferred Explain 0.00228
85 BAX gene Gene Inferred Explain 0.00224
86 Tamoxifen Compound Inferred Explain 0.00216
87 Cytoplasm Component Inferred Explain 0.00215
88 sulfinosine Compound Inferred Explain 0.00208
89 8-azidoadenosine 5'-triphosphate Compound Inferred Explain 0.00208
90 AG 1343 Compound Inferred Explain 0.00207
91 apicidin Compound Inferred Explain 0.00206
92 REL gene Gene Inferred Explain 0.00204
93 CYP1A1 gene Gene Inferred Explain 0.00202
94 Benzo(a)pyrene Compound Inferred Explain 0.00201
95 MIR21 gene Gene Inferred Explain 0.00199
96 C0019204 Other Inferred Explain 0.00194
97 peptidyl-proline modification Function Inferred Explain 0.00191
98 TOP2B gene Gene Inferred Explain 0.00188
99 acetochlor Compound Inferred Explain 0.00187
100 Hygromycin B Compound Inferred Explain 0.00185