Cyclosporine

Compound • C0010592

Definition

A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body. It is also used in clinical trials to make cancer cells more sensitive to anticancer drugs.

Synonyms

Cyclosporine • Cyclosporin • Ciclosporin • Cyclosporin A • Cyclosporine A • CYSP • CsA • Cyclosporine [Chemical/Ingredient]

Linked items?Related concepts, ordered by their global importance in the network.

TP53 gene    UBC gene    GABARAPL1 gene    MYC gene    EGFR gene    BCL2 gene    CYP3A4 gene    RELA gene    CASP3 gene    SH3GLB1 gene    AKT1 gene    AR gene    JUN gene    CYP1A1 gene    CDK2 gene    CTNNB1 gene    MAP1LC3B gene    CDKN1A gene    IL6 gene    IL8 gene   

Related concepts

# Concept name Type Relation Support Score
1 Aflatoxin B1 Compound Inferred Explain 0.01015
2 Benzo(a)pyrene Compound Inferred Explain 0.00876
3 Tetrachlorodibenzodioxin Compound Inferred Explain 0.00750
4 Cell Nucleus Component Inferred Explain 0.00747
5 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide Compound Inferred Explain 0.00745
6 Protein Binding Function Inferred Explain 0.00688
7 Cytoplasm Component Inferred Explain 0.00668
8 Membrane Component Inferred Explain 0.00594
9 integral to membrane Component Inferred Explain 0.00524
10 Estradiol Compound Inferred Explain 0.00496
11 Metal Ion Binding Function Inferred Explain 0.00417
12 pirinixic acid Compound Inferred Explain 0.00398
13 Calcium Valproate Compound Inferred Explain 0.00316
14 Mitochondria Component Inferred Explain 0.00285
15 Cell membrane Component Inferred Explain 0.00276
16 Selenium Compound Inferred Explain 0.00268
17 Vitamin E Compound Inferred Explain 0.00265
18 zinc ion binding Function Inferred Explain 0.00261
19 arsenic trioxide Compound Inferred Explain 0.00259
20 Cytoplasmic matrix Component Inferred Explain 0.00256
21 tert-Butylhydroperoxide Compound Inferred Explain 0.00247
22 nucleotide binding Function Inferred Explain 0.00239
23 Protoplasm Component Inferred Explain 0.00237
24 Fluorouracil Compound Inferred Explain 0.00205
25 Endoplasmic Reticulum Component Inferred Explain 0.00198
26 Selenite Compound Inferred Explain 0.00197
27 Calcitriol Compound Inferred Explain 0.00195
28 DNA Binding Function Inferred Explain 0.00191
29 hydrolase activity Function Inferred Explain 0.00170
30 Golgi Apparatus Component Inferred Explain 0.00161
31 extracellular region Component Inferred Explain 0.00154
32 ATP binding Function Inferred Explain 0.00148
33 bisphenol A Compound Inferred Explain 0.00146
34 Tretinoin Compound Inferred Explain 0.00146
35 Progesterone Compound Inferred Explain 0.00142
36 Hydralazine Compound Inferred Explain 0.00132
37 Endoplasmic reticulum, membrane Component Inferred Explain 0.00131
38 transferase activity Function Inferred Explain 0.00129
39 molecular_function Function Inferred Explain 0.00128
40 cellular_component Component Inferred Explain 0.00119
41 regulation of transcription, DNA-dependent Function Inferred Explain 0.00116
42 Genistein Compound Inferred Explain 0.00114
43 Water Compound Inferred Explain 0.00113
44 Signal Transduction Function Inferred Explain 0.00113
45 Physiological Processes Function Inferred Explain 0.00110
46 Cytoskeleton Component Inferred Explain 0.00109
47 Transcriptional Regulation Function Inferred Explain 0.00108
48 Binding (Molecular Function) Function Inferred Explain 0.00107
49 Adenosine Triphosphate Compound Inferred Explain 0.00107
50 decitabine Compound Inferred Explain 0.00106
51 Asbestos, Crocidolite Compound Inferred Explain 0.00105
52 Cell Nucleolus Component Inferred Explain 0.00099
53 integral to plasma membrane Component Inferred Explain 0.00096
54 GABARAPL1 gene Gene Known Explain 0.00095
55 transcription factor activity Function Inferred Explain 0.00093
56 Nucleoplasm Component Inferred Explain 0.00091
57 Doxorubicin Compound Inferred Explain 0.00091
58 sodium arsenite Compound Inferred Explain 0.00091
59 GRB2 gene Gene Inferred Explain 0.00090
60 Transmembrane Transport Function Inferred Explain 0.00089
61 Amiodarone Compound Inferred Explain 0.00087
62 7-ethyl-10-hydroxycamptothecin Compound Inferred Explain 0.00086
63 testosterone enanthate Compound Inferred Explain 0.00086
64 UVRAG gene Gene Inferred Explain 0.00085
65 multicellular organismal development Function Inferred Explain 0.00084
66 GABARAP gene Gene Inferred Explain 0.00084
67 SH3GLB1 gene Gene Known Explain 0.00080
68 Apoptosis Function Inferred Explain 0.00078
69 UBC gene Gene Known Explain 0.00078
70 Biological Transport Function Inferred Explain 0.00077
71 Golgi membrane Component Inferred Explain 0.00077
72 MYC gene Gene Known Explain 0.00075
73 protein transport Function Inferred Explain 0.00073
74 Adenosine Diphosphate Compound Inferred Explain 0.00073
75 TP53 gene Gene Known Explain 0.00073
76 Cell Cycle Function Inferred Explain 0.00070
77 calcium ion binding Function Inferred Explain 0.00070
78 Extracellular Space Other Inferred Explain 0.00068
79 MAP1LC3B gene Gene Known Explain 0.00066
80 Tamoxifen Compound Inferred Explain 0.00065
81 RNA Binding Function Inferred Explain 0.00065
82 resveratrol Compound Inferred Explain 0.00064
83 Raloxifene Compound Inferred Explain 0.00064
84 receptor activity Function Inferred Explain 0.00064
85 methylselenic acid Compound Inferred Explain 0.00064
86 oxidoreductase activity Function Inferred Explain 0.00063
87 ULK2 gene Gene Inferred Explain 0.00063
88 ESR1 gene Gene Inferred Explain 0.00062
89 Inner mitochondrial membrane Component Inferred Explain 0.00062
90 EGFR gene Gene Known Explain 0.00062
91 Quercetin Compound Inferred Explain 0.00062
92 RB1CC1 gene Gene Known Explain 0.00061
93 peptidase activity Function Inferred Explain 0.00060
94 TRAF6 gene Gene Inferred Explain 0.00059
95 Arsenic Compound Inferred Explain 0.00059
96 Mitotic Cell Cycle Function Inferred Explain 0.00059
97 Ion Transport Function Inferred Explain 0.00059
98 CDK2 gene Gene Known Explain 0.00058
99 Oxidation-Reduction Function Inferred Explain 0.00057
100 7-epi-Taxol Compound Inferred Explain 0.00057