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Churg-Strauss Syndrome
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Disease • C0008728
Definition
An autoimmune necrotizing vasculitis with the formation of granulomas. It is a pulmonary and systemic vasculitis associated with eosinophilia.
Synonyms
Churg-Strauss Syndrome • Churg Strauss Syndrome • Syndrome, Churg-Strauss • Allergic Angiitis • ANGIITIS, ALLERGIC • Allergic Angiitides • Angiitides, Allergic • Allergic granulomatosis • Angiitis, Allergic Granulomatous • Allergic granulomatous angiitis • Granulomatous allergic angiitis • Allergic Granulomatous Angiitides • Angiitides, Allergic Granulomatous • Granulomatous Angiitides, Allergic • Allergic granulomatous and angiitis • Granulomatous Angiitis, Allergic • Vasculitis, Churg-Strauss • Vasculitis, Churg Strauss • Churg-Strauss Vasculitis • ALLERGIC GRANULOMATOSIS OF CHURG-STRAUSS • Allergic angiitis and granulomatosis • Polyarteritis with lung involvement [Churg-Strauss] • Eosinophilic granulomatous vasculitis • Churg-Strauss Syndrome [Disease/Finding]
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zafirlukast
Granuloma
Adrenal Cortex Hormones
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
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Related concepts
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#
|
Concept name
|
Type
|
Relation
|
Support
|
Score
|
|
1
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
Disease
|
Known
|
Explain
|
188.15226
|
|
2
|
Adrenal Cortex Hormones
|
Compound
|
Known
|
Explain
|
123.56292
|
|
3
|
Granuloma
|
Disease
|
Known
|
Explain
|
88.27097
|
|
4
|
zafirlukast
|
Compound
|
Known
|
Explain
|
34.65970
|
|
5
|
Systemic Vasculitis
|
Disease
|
Inferred
|
Explain
|
7.62843
|
|
6
|
Wegener Granulomatosis
|
Disease
|
Inferred
|
Explain
|
5.96740
|
|
7
|
Granuloma Annulare
|
Disease
|
Inferred
|
Explain
|
1.17943
|
|
8
|
Autoimmune Diseases
|
Disease
|
Inferred
|
Explain
|
1.15414
|
|
9
|
Granuloma, Foreign-Body
|
Disease
|
Inferred
|
Explain
|
1.06990
|
|
10
|
Rheumatoid Vasculitis
|
Disease
|
Inferred
|
Explain
|
1.06152
|
|
11
|
Pyogenic granuloma
|
Disease
|
Inferred
|
Explain
|
1.02433
|
|
12
|
Epithelioid hemangioma of skin
|
Disease
|
Inferred
|
Explain
|
0.98417
|
|
13
|
Polyarteritis Nodosa
|
Disease
|
Inferred
|
Explain
|
0.90051
|
|
14
|
Granuloma, Respiratory Tract
|
Disease
|
Inferred
|
Explain
|
0.88213
|
|
15
|
Eosinophilic Granuloma
|
Disease
|
Inferred
|
Explain
|
0.86096
|
|
16
|
Giant Cell Granuloma
|
Disease
|
Inferred
|
Explain
|
0.83780
|
|
17
|
Beryllium
|
Compound
|
Inferred
|
Explain
|
0.69720
|
|
18
|
FCGR3B gene
|
Gene
|
Inferred
|
Explain
|
0.60910
|
|
19
|
Lung Diseases, Interstitial
|
Disease
|
Inferred
|
Explain
|
0.59230
|
|
20
|
Vasculitis
|
Disease
|
Inferred
|
Explain
|
0.54345
|
|
21
|
Hydroxycorticosteroids
|
Compound
|
Inferred
|
Explain
|
0.53452
|
|
22
|
17-Ketosteroids
|
Compound
|
Inferred
|
Explain
|
0.41261
|
|
23
|
Foreign-Body Reaction
|
Disease
|
Inferred
|
Explain
|
0.37011
|
|
24
|
Glucocorticoids
|
Compound
|
Inferred
|
Explain
|
0.35477
|
|
25
|
Lymphoproliferative Disorders
|
Disease
|
Inferred
|
Explain
|
0.25012
|
|
26
|
Necrobiotic Disorders
|
Disease
|
Inferred
|
Explain
|
0.24453
|
|
27
|
Eosinophilia
|
Disease
|
Inferred
|
Explain
|
0.23018
|
|
28
|
IL3 gene
|
Gene
|
Inferred
|
Explain
|
0.21601
|
|
29
|
Hormones
|
Compound
|
Inferred
|
Explain
|
0.21208
|
|
30
|
IL5RA gene
|
Gene
|
Inferred
|
Explain
|
0.20116
|
|
31
|
Arteritis
|
Disease
|
Inferred
|
Explain
|
0.19471
|
|
32
|
Granuloma, Laryngeal
|
Disease
|
Inferred
|
Explain
|
0.16483
|
|
33
|
Histiocytosis, Langerhans-Cell
|
Disease
|
Inferred
|
Explain
|
0.14695
|
|
34
|
Pathologic Processes
|
Disease
|
Inferred
|
Explain
|
0.14506
|
|
35
|
Asthma
|
Disease
|
Inferred
|
Explain
|
0.13781
|
|
36
|
Skin Diseases, Vascular
|
Disease
|
Inferred
|
Explain
|
0.12921
|
|
37
|
Jaw Diseases
|
Disease
|
Inferred
|
Explain
|
0.10931
|
|
38
|
Gingival Diseases
|
Disease
|
Inferred
|
Explain
|
0.10769
|
|
39
|
Dapsone
|
Compound
|
Inferred
|
Explain
|
0.09154
|
|
40
|
IL5 gene
|
Gene
|
Inferred
|
Explain
|
0.08209
|
|
41
|
IL12A gene
|
Gene
|
Inferred
|
Explain
|
0.06955
|
|
42
|
Rheumatoid Arthritis
|
Disease
|
Inferred
|
Explain
|
0.06310
|
|
43
|
Respiratory Tract Diseases
|
Disease
|
Inferred
|
Explain
|
0.05903
|
|
44
|
IL12B gene
|
Gene
|
Inferred
|
Explain
|
0.04794
|
|
45
|
Decompression Sickness
|
Disease
|
Inferred
|
Explain
|
0.04172
|
|
46
|
Necrobiosis Lipoidica
|
Disease
|
Inferred
|
Explain
|
0.03998
|
|
47
|
Dermatologic disorders
|
Disease
|
Inferred
|
Explain
|
0.03702
|
|
48
|
Pharyngitis
|
Disease
|
Inferred
|
Explain
|
0.03409
|
|
49
|
Candidiasis of vagina
|
Disease
|
Inferred
|
Explain
|
0.03386
|
|
50
|
Bone Diseases
|
Disease
|
Inferred
|
Explain
|
0.03319
|
|
51
|
S 26308
|
Compound
|
Inferred
|
Explain
|
0.03265
|
|
52
|
Allergic Conjunctivitis
|
Disease
|
Inferred
|
Explain
|
0.03157
|
|
53
|
Lung Diseases, Obstructive
|
Disease
|
Inferred
|
Explain
|
0.03138
|
|
54
|
Asthma, Exercise-Induced
|
Disease
|
Inferred
|
Explain
|
0.03036
|
|
55
|
Leukocytosis
|
Disease
|
Inferred
|
Explain
|
0.02853
|
|
56
|
Chronic Obstructive Airway Disease
|
Disease
|
Inferred
|
Explain
|
0.02612
|
|
57
|
Nasal Polyps
|
Other
|
Inferred
|
Explain
|
0.02433
|
|
58
|
Allergic rhinitis (disorder)
|
Disease
|
Inferred
|
Explain
|
0.02394
|
|
59
|
Bronchial Diseases
|
Disease
|
Inferred
|
Explain
|
0.02192
|
|
60
|
Pulmonary Edema
|
Disease
|
Inferred
|
Explain
|
0.02166
|
|
61
|
Metals, Light
|
Compound
|
Inferred
|
Explain
|
0.02153
|
|
62
|
Berylliosis
|
Other
|
Inferred
|
Explain
|
0.02121
|
|
63
|
Vasculitis, Central Nervous System
|
Disease
|
Inferred
|
Explain
|
0.02113
|
|
64
|
Asthma, Aspirin-Induced
|
Disease
|
Inferred
|
Explain
|
0.02065
|
|
65
|
Necrosis
|
Disease
|
Inferred
|
Explain
|
0.02040
|
|
66
|
Rhinitis
|
Disease
|
Inferred
|
Explain
|
0.02016
|
|
67
|
Collagen Diseases
|
Disease
|
Inferred
|
Explain
|
0.01969
|
|
68
|
Sinusitis
|
Disease
|
Inferred
|
Explain
|
0.01863
|
|
69
|
VASCULITIS, LYMPHOCYTIC, CUTANEOUS SMALL VESSEL
|
Disease
|
Inferred
|
Explain
|
0.01841
|
|
70
|
VASCULITIS, LYMPHOCYTIC, NODULAR
|
Disease
|
Inferred
|
Explain
|
0.01841
|
|
71
|
zileuton
|
Compound
|
Inferred
|
Explain
|
0.01833
|
|
72
|
Metals, Alkaline Earth
|
Compound
|
Inferred
|
Explain
|
0.01797
|
|
73
|
CYSLTR2 gene
|
Gene
|
Inferred
|
Explain
|
0.01795
|
|
74
|
LTB4R2 gene
|
Gene
|
Inferred
|
Explain
|
0.01750
|
|
75
|
Nausea
|
Disease
|
Inferred
|
Explain
|
0.01721
|
|
76
|
Headache
|
Disease
|
Inferred
|
Explain
|
0.01677
|
|
77
|
Anti-Glomerular Basement Membrane Disease
|
Disease
|
Inferred
|
Explain
|
0.01666
|
|
78
|
RNASE3 gene
|
Gene
|
Inferred
|
Explain
|
0.01642
|
|
79
|
Foreign Bodies
|
Other
|
Inferred
|
Explain
|
0.01579
|
|
80
|
Endometriosis, site unspecified
|
Disease
|
Inferred
|
Explain
|
0.01574
|
|
81
|
Coughing
|
Disease
|
Inferred
|
Explain
|
0.01550
|
|
82
|
Inflammation
|
Disease
|
Inferred
|
Explain
|
0.01542
|
|
83
|
Giant Cell Arteritis
|
Disease
|
Inferred
|
Explain
|
0.01461
|
|
84
|
Urticaria
|
Disease
|
Inferred
|
Explain
|
0.01401
|
|
85
|
HLA-DPB1 gene
|
Gene
|
Inferred
|
Explain
|
0.01380
|
|
86
|
Malignant Atrophic Papulosis
|
Disease
|
Inferred
|
Explain
|
0.01378
|
|
87
|
Mucocutaneous Lymph Node Syndrome
|
Disease
|
Inferred
|
Explain
|
0.01243
|
|
88
|
CYSLTR1 gene
|
Gene
|
Inferred
|
Explain
|
0.01241
|
|
89
|
Skin Diseases, Metabolic
|
Disease
|
Inferred
|
Explain
|
0.01233
|
|
90
|
Ayerza Syndrome
|
Disease
|
Inferred
|
Explain
|
0.01163
|
|
91
|
Lymphocyte
|
Other
|
Inferred
|
Explain
|
0.01114
|
|
92
|
Vasculitis Adverse Event
|
Disease
|
Inferred
|
Explain
|
0.01112
|
|
93
|
Hepatitis
|
Disease
|
Inferred
|
Explain
|
0.01093
|
|
94
|
Pancreatitis
|
Disease
|
Inferred
|
Explain
|
0.01046
|
|
95
|
Hypersensitivity vasculitis
|
Disease
|
Inferred
|
Explain
|
0.01012
|
|
96
|
Dermatitis, Atopic
|
Disease
|
Inferred
|
Explain
|
0.00987
|
|
97
|
Takayasu Arteritis
|
Disease
|
Inferred
|
Explain
|
0.00977
|
|
98
|
Cervical Migraine Syndrome
|
Disease
|
Inferred
|
Explain
|
0.00958
|
|
99
|
Behcet Syndrome
|
Disease
|
Inferred
|
Explain
|
0.00954
|
|
100
|
Aortitis
|
Disease
|
Inferred
|
Explain
|
0.00947
|
|