anaphylaxis

Disease • C0002792

Definition

An acute inflammatory reaction resulting from the release of histamine and histamine-like substances from mast cells, causing a hypersensitivity immune response. Clinically, it presents with breathing difficulty, dizziness, hypotension, cyanosis and loss

Synonyms

anaphylaxis • Shock, Anaphylactic • ANAPHYLACTIC SHOCK • Anaphylactic Reaction • REACTION, ANAPHYLACTIC • Anaphylactic Reactions • Reactions, Anaphylactic • ANAPHYLAXIS, GENERALIZED • Allergic shock • Anaphylactic shock, unspecified • Anaphylaxis [Disease/Finding]

Linked items?Related concepts, ordered by their global importance in the network.

Ibuprofen    KNG1 gene    mangiferin    LTB4R gene    Immediate hypersensitivity    Mangifera indica extract    Cromoglycate   

Related concepts

# Concept name Type Relation Support Score
1 Cromoglycate Compound Known Explain 76.34292
2 Mangifera indica extract Compound Known Explain 35.67856
3 LTB4R gene Gene Known Explain 32.20451
4 Immediate hypersensitivity Disease Known Explain 23.62157
5 mangiferin Compound Known Explain 15.19732
6 Endotoxic shock Disease Inferred Explain 11.00940
7 KNG1 gene Gene Known Explain 10.39732
8 Ibuprofen Compound Known Explain 5.07749
9 Edema Disease Inferred Explain 2.12619
10 Trichinellosis Disease Inferred Explain 0.41461
11 Hypersensitivity Disease Inferred Explain 0.21588
12 type I hypersensitivity mediated by basophils Disease Inferred Explain 0.16647
13 Ischemia Disease Inferred Explain 0.16032
14 endotoxin, Escherichia coli Compound Inferred Explain 0.12606
15 Enoplida Infections Disease Inferred Explain 0.11811
16 type I hypersensitivity mediated by mast cells Disease Inferred Explain 0.11313
17 Glucose Metabolism Disorders Disease Inferred Explain 0.11018
18 Diphenhydramine Hydrochloride Compound Inferred Explain 0.10468
19 Food Allergy Disease Inferred Explain 0.10280
20 leukotriene receptor activity Function Inferred Explain 0.08324
21 leukotriene B4 receptor activity Function Inferred Explain 0.08063
22 Herpes Simplex Infections Disease Inferred Explain 0.07748
23 Inflammation Disease Inferred Explain 0.07731
24 Triprolidine Compound Inferred Explain 0.07288
25 Allergic Conjunctivitis Disease Inferred Explain 0.07093
26 IgE RESPONSIVENESS, ATOPIC Disease Inferred Explain 0.06164
27 Gastric ulcer Disease Inferred Explain 0.05991
28 Cereal allergen/alpha-amylase inhibitor, rice-type Domain Inferred Explain 0.05891
29 immunoglobulin mediated immune response Function Inferred Explain 0.05677
30 basophil mediated immunity Function Inferred Explain 0.05639
31 PLA2G2A gene Gene Inferred Explain 0.05388
32 Atherosclerosis Disease Inferred Explain 0.05278
33 Asthma, Aspirin-Induced Disease Inferred Explain 0.05162
34 mast cell mediated immunity Function Inferred Explain 0.04625
35 beta-Lactams Compound Inferred Explain 0.04613
36 Adenophorea Infections Disease Inferred Explain 0.04269
37 C5AR1 gene Gene Inferred Explain 0.03809
38 MS4A2 gene Gene Inferred Explain 0.03666
39 myeloid leukocyte mediated immunity Function Inferred Explain 0.03484
40 Urticaria Disease Inferred Explain 0.03466
41 Respiratory Hypersensitivity Disease Inferred Explain 0.03168
42 KWD-2019 Compound Inferred Explain 0.02763
43 Pain Disease Inferred Explain 0.02757
44 Dermatitis, Atopic Disease Inferred Explain 0.02649
45 IL13 gene Gene Inferred Explain 0.01981
46 Pericementitis Disease Inferred Explain 0.01837
47 Hyperinsulinism Disease Inferred Explain 0.01730
48 Radiation Injuries, Experimental Other Inferred Explain 0.01549
49 GRK6 gene Gene Inferred Explain 0.01509
50 IL4 gene Gene Inferred Explain 0.01449
51 GNA15 gene Gene Inferred Explain 0.01366
52 Nematode infections Disease Inferred Explain 0.01322
53 Immune System Diseases Disease Inferred Explain 0.01288
54 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger Function Inferred Explain 0.01276
55 LTB4R2 gene Gene Inferred Explain 0.01241
56 Cryptosporidiosis Disease Inferred Explain 0.01148
57 IL10 gene Gene Inferred Explain 0.01054
58 Proteinase inhibitor I25, cystatin Domain Inferred Explain 0.01052
59 BAY u 3406 Compound Inferred Explain 0.01045
60 Proteinase inhibitor I25, cystatin, conserved site Domain Inferred Explain 0.01032
61 Cytomel Compound Inferred Explain 0.00947
62 Type III hypersensitivity cellular communication Disease Inferred Explain 0.00878
63 zafirlukast Compound Inferred Explain 0.00865
64 type II cellular hypersensitivity Disease Inferred Explain 0.00860
65 Diabetic Nephropathy Disease Inferred Explain 0.00793
66 Alloxan Diabetes Disease Inferred Explain 0.00783
67 Learning Disorders Disease Inferred Explain 0.00744
68 Inflammatory Response Disease Inferred Explain 0.00734
69 Memory Disorders Disease Inferred Explain 0.00729
70 Hyperlipidemia Disease Inferred Explain 0.00640
71 cellular component movement Function Inferred Explain 0.00633
72 Insulin Resistance Disease Inferred Explain 0.00629
73 CYSLTR2 gene Gene Inferred Explain 0.00626
74 H-D-Arg-Arg-Pro-Hyp-Gly-Thi-c(Dab-DTic-Oic-Arg)c(7gamma-10alpha) Compound Inferred Explain 0.00625
75 LF 16-0687 Compound Inferred Explain 0.00625
76 Nerve Degeneration Disease Inferred Explain 0.00622
77 TNF gene Gene Inferred Explain 0.00618
78 Drug Allergy Disease Inferred Explain 0.00596
79 Isopromethazine Compound Inferred Explain 0.00593
80 HRH1 gene Gene Inferred Explain 0.00581
81 Myocardial Infarction Disease Inferred Explain 0.00580
82 Chlorpropamide Compound Inferred Explain 0.00568
83 Muscle Contraction Function Inferred Explain 0.00556
84 (E)-3-((6-acetamido-3-pyridyl)-N-(N-(2,4-dichloro-3-((2-methyl-8-quinolinyl)oxymethyl)phenyl)-N-methyl) aminocarbonyl methyl)acrylamide Compound Inferred Explain 0.00555
85 Bone Resorption Function Inferred Explain 0.00555
86 Endotoxemia Disease Inferred Explain 0.00547
87 ONO-RS 411 Compound Inferred Explain 0.00542
88 Rabbit Aorta Contracting Substance Compound Inferred Explain 0.00540
89 Fatty Liver Disease Inferred Explain 0.00535
90 HOE 140 Compound Inferred Explain 0.00526
91 Myeloid Leukemia, Chronic Disease Inferred Explain 0.00516
92 Liver diseases Disease Inferred Explain 0.00512
93 Leukotriene B4 receptor Domain Inferred Explain 0.00503
94 Hyperalgesia Disease Inferred Explain 0.00501
95 No-Reflow Phenomenon Disease Inferred Explain 0.00472
96 Rhinitis Disease Inferred Explain 0.00441
97 SLC11A1 gene Gene Inferred Explain 0.00437
98 Infarction Disease Inferred Explain 0.00433
99 RXFP4 gene Gene Inferred Explain 0.00414
100 BDKRB2 gene Gene Inferred Explain 0.00408