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Afibrinogenemia
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Disease • C0001733
Definition
A usually inherited blood coagulation disorder characterized by the lack of fibrinogen in the blood, resulting in bleeding.
Synonyms
Afibrinogenemia • Afibrinogenemias • Fibrinogen Deficiency • Deficiency, fibrinogen • Deficiencies, Fibrinogen • Fibrinogen Deficiencies • FACTOR I DEFICIENCY, COMPLETE • Factor I Deficiency • DEFICIENCY FACTOR I • Deficiency, factor I • COMPLEMENT COMPONENT 3 INACTIVATOR DEFICIENCY • DEFIC FIBRINOGEN • FIBRINOGEN DEFIC • C3 INACTIVATOR DEFICIENCY • COMPLEMENT FACTOR I DEFICIENCY • Afibrinogenemia [Disease/Finding] • Deficiency of factor I [fibrinogen]
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FGA gene
FGB gene
Hemorrhagic Disorders
Blood Coagulation Disorders, Inherited
CFI gene
Coagulation Protein Disorders
Hereditary factor I deficiency disease
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Related concepts
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#
|
Concept name
|
Type
|
Relation
|
Support
|
Score
|
|
1
|
Hereditary factor I deficiency disease
|
Disease
|
Known
|
Explain
|
86.04234
|
|
2
|
Coagulation Protein Disorders
|
Disease
|
Known
|
Explain
|
41.15889
|
|
3
|
FGB gene
|
Gene
|
Known
|
Explain
|
37.67253
|
|
4
|
CFI gene
|
Gene
|
Known
|
Explain
|
37.54695
|
|
5
|
Blood Coagulation Disorders, Inherited
|
Disease
|
Known
|
Explain
|
30.71899
|
|
6
|
FGA gene
|
Gene
|
Known
|
Explain
|
28.32322
|
|
7
|
Hemorrhagic Disorders
|
Disease
|
Known
|
Explain
|
27.86478
|
|
8
|
Factor VII Deficiency
|
Disease
|
Inferred
|
Explain
|
1.20608
|
|
9
|
Hypoprothrombinemias
|
Disease
|
Inferred
|
Explain
|
1.20580
|
|
10
|
Factor V Deficiency
|
Disease
|
Inferred
|
Explain
|
1.20033
|
|
11
|
Factor X Deficiency
|
Disease
|
Inferred
|
Explain
|
1.19101
|
|
12
|
Factor XI Deficiency
|
Disease
|
Inferred
|
Explain
|
1.18556
|
|
13
|
Factor XII Deficiency
|
Disease
|
Inferred
|
Explain
|
1.16721
|
|
14
|
Factor XIII Deficiency
|
Disease
|
Inferred
|
Explain
|
1.12194
|
|
15
|
Hemophilia B
|
Disease
|
Inferred
|
Explain
|
1.06773
|
|
16
|
Hemophilia A
|
Disease
|
Inferred
|
Explain
|
0.94147
|
|
17
|
von Willebrand Disease
|
Disease
|
Inferred
|
Explain
|
0.82141
|
|
18
|
Activated Protein C Resistance
|
Disease
|
Inferred
|
Explain
|
0.75500
|
|
19
|
Blood Coagulation Disorders
|
Disease
|
Inferred
|
Explain
|
0.53059
|
|
20
|
Thrombasthenia
|
Disease
|
Inferred
|
Explain
|
0.34997
|
|
21
|
Wiskott-Aldrich Syndrome
|
Disease
|
Inferred
|
Explain
|
0.31771
|
|
22
|
Hermanski-Pudlak Syndrome
|
Disease
|
Inferred
|
Explain
|
0.29800
|
|
23
|
Bernard-Soulier Syndrome
|
Disease
|
Inferred
|
Explain
|
0.27476
|
|
24
|
Blood Platelet Disorders
|
Disease
|
Inferred
|
Explain
|
0.22600
|
|
25
|
Platelet Storage Pool Deficiency
|
Disease
|
Inferred
|
Explain
|
0.17654
|
|
26
|
Gray Platelet Syndrome
|
Disease
|
Inferred
|
Explain
|
0.14691
|
|
27
|
Disseminated Intravascular Coagulation
|
Disease
|
Inferred
|
Explain
|
0.14334
|
|
28
|
Thrombophilia
|
Disease
|
Inferred
|
Explain
|
0.13626
|
|
29
|
F7 gene
|
Gene
|
Inferred
|
Explain
|
0.12482
|
|
30
|
Antithrombin III Deficiency
|
Disease
|
Inferred
|
Explain
|
0.12305
|
|
31
|
Thrombocythemia, Essential
|
Disease
|
Inferred
|
Explain
|
0.12096
|
|
32
|
Protein C Deficiency
|
Disease
|
Inferred
|
Explain
|
0.11537
|
|
33
|
Vitamin K Deficiency
|
Disease
|
Inferred
|
Explain
|
0.11471
|
|
34
|
Waterhouse-Friderichsen Syndrome
|
Disease
|
Inferred
|
Explain
|
0.08677
|
|
35
|
FGG gene
|
Gene
|
Inferred
|
Explain
|
0.08343
|
|
36
|
Purpura, Thrombocytopenic, Idiopathic
|
Disease
|
Inferred
|
Explain
|
0.07612
|
|
37
|
F13B gene
|
Gene
|
Inferred
|
Explain
|
0.07449
|
|
38
|
estradiol valerate-dienogest
|
Compound
|
Inferred
|
Explain
|
0.06858
|
|
39
|
Complement and coagulation cascades - Homo sapiens (human)
|
Pathway
|
Inferred
|
Explain
|
0.06849
|
|
40
|
F9 gene
|
Gene
|
Inferred
|
Explain
|
0.06625
|
|
41
|
F13A1 gene
|
Gene
|
Inferred
|
Explain
|
0.06590
|
|
42
|
F11 gene
|
Gene
|
Inferred
|
Explain
|
0.06554
|
|
43
|
Hematological Disease
|
Disease
|
Inferred
|
Explain
|
0.05729
|
|
44
|
F5 gene
|
Gene
|
Inferred
|
Explain
|
0.05543
|
|
45
|
platelet alpha granule
|
Component
|
Inferred
|
Explain
|
0.05473
|
|
46
|
fibrinogen complex location
|
Component
|
Inferred
|
Explain
|
0.05457
|
|
47
|
dienogest
|
Compound
|
Inferred
|
Explain
|
0.05404
|
|
48
|
Gestodene
|
Compound
|
Inferred
|
Explain
|
0.05234
|
|
49
|
Desogestrel
|
Compound
|
Inferred
|
Explain
|
0.04646
|
|
50
|
Norethindrone
|
Compound
|
Inferred
|
Explain
|
0.04602
|
|
51
|
F2 gene
|
Gene
|
Inferred
|
Explain
|
0.04530
|
|
52
|
Mercilon
|
Compound
|
Inferred
|
Explain
|
0.04418
|
|
53
|
Genetic Diseases, X-Linked
|
Disease
|
Inferred
|
Explain
|
0.04412
|
|
54
|
norgestimate
|
Compound
|
Inferred
|
Explain
|
0.04361
|
|
55
|
F10 gene
|
Gene
|
Inferred
|
Explain
|
0.04194
|
|
56
|
Vascular Hemostatic Disorders
|
Disease
|
Inferred
|
Explain
|
0.04026
|
|
57
|
Hemolytic-Uremic Syndrome
|
Disease
|
Inferred
|
Explain
|
0.03951
|
|
58
|
eukaryotic cell surface binding
|
Function
|
Inferred
|
Explain
|
0.03816
|
|
59
|
F12 gene
|
Gene
|
Inferred
|
Explain
|
0.03785
|
|
60
|
PROC gene
|
Gene
|
Inferred
|
Explain
|
0.03417
|
|
61
|
SERPINA5 gene
|
Gene
|
Inferred
|
Explain
|
0.02967
|
|
62
|
Levonorgestrel
|
Compound
|
Inferred
|
Explain
|
0.02850
|
|
63
|
CFH gene
|
Gene
|
Inferred
|
Explain
|
0.02833
|
|
64
|
platelet alpha granule lumen
|
Component
|
Inferred
|
Explain
|
0.02608
|
|
65
|
MIS12 gene
|
Gene
|
Inferred
|
Explain
|
0.02240
|
|
66
|
P2RX1 gene
|
Gene
|
Inferred
|
Explain
|
0.02170
|
|
67
|
protein polymerization
|
Function
|
Inferred
|
Explain
|
0.02167
|
|
68
|
Blood Protein Disorders
|
Disease
|
Inferred
|
Explain
|
0.02075
|
|
69
|
complement activation, classical pathway
|
Function
|
Inferred
|
Explain
|
0.02045
|
|
70
|
Lymphopenia
|
Disease
|
Inferred
|
Explain
|
0.02001
|
|
71
|
KLK6 gene
|
Gene
|
Inferred
|
Explain
|
0.01939
|
|
72
|
VWF gene
|
Gene
|
Inferred
|
Explain
|
0.01859
|
|
73
|
KEGG:hsa05150
|
Pathway
|
Inferred
|
Explain
|
0.01852
|
|
74
|
platelet degranulation
|
Function
|
Inferred
|
Explain
|
0.01840
|
|
75
|
ITGA2B gene
|
Gene
|
Inferred
|
Explain
|
0.01834
|
|
76
|
NID1 gene
|
Gene
|
Inferred
|
Explain
|
0.01823
|
|
77
|
KHDRBS2 gene
|
Gene
|
Inferred
|
Explain
|
0.01770
|
|
78
|
protein binding, bridging
|
Function
|
Inferred
|
Explain
|
0.01729
|
|
79
|
response to calcium ion
|
Function
|
Inferred
|
Explain
|
0.01686
|
|
80
|
Genetic Diseases, Inborn
|
Disease
|
Inferred
|
Explain
|
0.01565
|
|
81
|
Protein S Deficiency
|
Disease
|
Inferred
|
Explain
|
0.01523
|
|
82
|
Malnutrition
|
Disease
|
Inferred
|
Explain
|
0.01516
|
|
83
|
MTHFR gene
|
Gene
|
Inferred
|
Explain
|
0.01475
|
|
84
|
C3 gene
|
Gene
|
Inferred
|
Explain
|
0.01457
|
|
85
|
SERPINC1 gene
|
Gene
|
Inferred
|
Explain
|
0.01457
|
|
86
|
scavenger receptor activity
|
Function
|
Inferred
|
Explain
|
0.01392
|
|
87
|
GIANT PLATELET SYNDROME WITH THROMBOCYTOPENIA
|
Disease
|
Inferred
|
Explain
|
0.01384
|
|
88
|
F8 gene
|
Gene
|
Inferred
|
Explain
|
0.01347
|
|
89
|
HEMOPHILIA A WITH VASCULAR ABNORMALITY
|
Disease
|
Inferred
|
Explain
|
0.01312
|
|
90
|
Amyloidosis, familial visceral
|
Disease
|
Inferred
|
Explain
|
0.01246
|
|
91
|
Thrombocytosis
|
Disease
|
Inferred
|
Explain
|
0.01225
|
|
92
|
PLAT gene
|
Gene
|
Inferred
|
Explain
|
0.01216
|
|
93
|
Purpura
|
Disease
|
Inferred
|
Explain
|
0.01186
|
|
94
|
PROS1 gene
|
Gene
|
Inferred
|
Explain
|
0.01065
|
|
95
|
Blood Platelets
|
Other
|
Inferred
|
Explain
|
0.01026
|
|
96
|
von Willebrand Disease, Type 3
|
Disease
|
Inferred
|
Explain
|
0.01019
|
|
97
|
VON WILLEBRAND DISEASE, X-LINKED FORM
|
Disease
|
Inferred
|
Explain
|
0.01019
|
|
98
|
GP1BA gene
|
Gene
|
Inferred
|
Explain
|
0.01018
|
|
99
|
Ethinyl Estradiol
|
Compound
|
Inferred
|
Explain
|
0.01005
|
|
100
|
Von Willebrand disease, platelet type
|
Disease
|
Inferred
|
Explain
|
0.00999
|
|