BioGraph

In the context of Chronic Fatigue Syndrome, COMT gene has rank 235 out of 18180 'Gene' concepts (top 1.29%).

Chronic Fatigue Syndrome: A syndrome of unknown etiology. Chronic fatigue syndrome (CFS) is a clinical diagnosis characterized by an unexplained persistent or relapsing chronic fatigue that is of at least six months' duration, is not the result of ongoing exertion, is not substant[...]

COMT gene: This gene is involved in the metabolism of catecholamine drugs and neurotransmitters.[...]

This is an inferred relation: The relation among these concepts has not been integrated in BioGraph's knowledge base as a known relation. The following information provides information on inferred relations between the concepts.

Score	Value
Ranking score	0.007184097848227966
Global rank	1.98% (1407th out of 70994 entities)
Gene rank	1.29% (235th out of 18180 'Gene' entities)

Putative functional relations

The following trails provide putative functional links between Chronic Fatigue Syndrome (context) and COMT gene (target)

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Edges

From	To	Support
COMT gene	4-methylcatechol	Explain
4-methylcatechol	Peripheral Neuropathy	Explain
Peripheral Neuropathy	Neuromuscular Diseases	Explain
Neuromuscular Diseases	Chronic Fatigue Syndrome	Explain
Myopathy	Chronic Fatigue Syndrome	Explain
MAOA gene	Myopathy	Explain
ACE gene	CNS disorder	Explain
CNS disorder	Encephalomyelitis	Explain
COMT gene	ACE gene	Explain
Encephalomyelitis	Chronic Fatigue Syndrome	Explain
L-Metanephrine	MAOA gene	Explain
COMT gene	L-Metanephrine	Explain
COMT gene	3-Methoxytyramine	Explain
L-Normetanephrine	MAOA gene	Explain
COMT gene	L-Normetanephrine	Explain
3-Methoxytyramine	MAOA gene	Explain
COMT gene	Lamivudine	Explain
Lamivudine	Rhabdomyolysis	Explain
Rhabdomyolysis	Myopathy	Explain
dopamine catabolic process	MAOA gene	Explain
COMT gene	dopamine catabolic process	Explain
Epinephrine	MAOA gene	Explain
COMT gene	Epinephrine	Explain
COMT gene	Norepinephrine	Explain
Norepinephrine	MAOA gene	Explain
COMT gene	neurotransmitter catabolic process	Explain
neurotransmitter catabolic process	MAOA gene	Explain

Publications on these concepts

Literature search on PubMed for this relation:

Löbel et al., Polymorphism in COMT is associated with IgG3 subclass level and susceptibility to infection in patients with chronic fatigue syndrome. (2015)
Light et al., Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome. (2012)
Sommerfeldt et al., Polymorphisms of adrenergic cardiovascular control genes are associated with adolescent chronic fatigue syndrome. (2011)
Light et al., Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects. (2009)
Goertzel et al., Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome. (2006)
Watanabe et al., Association between catechol-O-methyltransferase gene polymorphisms and wearing-off and dyskinesia in Parkinson's disease. (2003)

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Relations between Chronic Fatigue Syndrome and COMT gene

Putative functional relations

Edges

Publications on these concepts

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