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In the context of Caffeine, CYP1A2 gene has rank 70 out of 18180 'Gene' concepts (top 0.39%).

Caffeine: An alkaloid stimulant having a purine double-ring structure composed of eight carbons and four nitrogen atoms with methyl groups attached to the nitrogen atoms at the 1, 3, and 7 positions and having double bonds at the carbons in positions 2 and 6.[...]

CYP1A2 gene: This gene plays a role in the oxidation/activation of procarcinogens. It is also involved in the metabolism of drugs and other xenobiotics.[...]

This is a known relation: The relation among these concepts has been integrated in BioGraph's knowledge base as a known relation.

ScoreValue
Ranking score 0.23908766990667113
Global rank 0.11% (76th out of 70994 entities)
Gene rank 0.39% (70th out of 18180 'Gene' entities)

Putative functional relations

The following trails provide putative functional links between Caffeine (context) and CYP1A2 gene (target)

Click the links in the network to explore intermediate links.

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%3 26298 CYP1A2 gene 1328 Caffeine 1328--26298 activity, binding, metabolic processing, methylation, reaction 9076 Xanthines 1328--9076 ontology 33238 XDH gene 1328--33238 metabolic processing 14722 NAT2 gene 1328--14722 acetylation, metabolic processing 14440 Long Sleeper Syndrome 1328--14440 disease marker 8405 Theobromine 8405--26298 metabolic processing, reaction 9076--8405 ontology 13811 bakumondo- to 13811--26298 activity 33238--13811 activity 33238--8405 reaction 1705 Chlorzoxazone 33238--1705 metabolic processing 14722--13811 activity 9227 2-aminofluorene 14722--9227 acetylation 1476 Carotene 14722--1476 response to chemical 14722--1705 metabolic processing 9227--26298 metabolic processing 1476--26298 response to chemical 238 Trittico 238--26298 abundance 14440--238 disease drug 1705--26298 metabolic processing

Edges

From To Probability Support
CYP1A2 gene Caffeine
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CYP1A2 gene Theobromine
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Xanthines Caffeine
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Theobromine Xanthines
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NAT2 gene Caffeine
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XDH gene Caffeine
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CYP1A2 gene bakumondo-to
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bakumondo-to XDH gene
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CYP1A2 gene Chlorzoxazone
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CYP1A2 gene 2-aminofluorene
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bakumondo-to NAT2 gene
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CYP1A2 gene Carotene
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Carotene NAT2 gene
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2-aminofluorene NAT2 gene
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Theobromine XDH gene
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CYP1A2 gene Trittico
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Long Sleeper Syndrome Caffeine
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Trittico Long Sleeper Syndrome
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Chlorzoxazone XDH gene
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Chlorzoxazone NAT2 gene
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Publications

This relation is supported by the following publications in BioGraph.

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Resource databases

The following database(s) have been used to integrate this relation into our knowledge base:

Acronym Name URL
CTD-CG The Comparative Toxicogenomics Database - Curated Chemical-Gene Interactions http://ctd.mdibl.org
KEGG Kyoto Encyclopedia of Genes and Genomes http://www.genome.jp/kegg/